Seizures as a Complication of Congenital Zika Syndrome in Early Infancy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.4269/ajtmh.17-1020 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27985 |
Resumo: | NIH Grants RO1 NS064905, NIH R01 AI052473, U01 AI088752, and R25 TW009338, and the Oswaldo Cruz Foundation |
| id |
CRUZ_a7952746f123885dd466b3ccb6aa46ab |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/27985 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Oliveira Filho, JamaryFelzemburgh, Ridalva Dias MartinsCosta, FedericoNery Júnior, Nivison Ruy RochaMattos, AdrianaHenriques, Daniele FreitasKo, Albert IcksangFor The Salvador Zika Response Team2018-08-07T15:44:32Z2018-08-07T15:44:32Z2018OLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018.0002-9637https://www.arca.fiocruz.br/handle/icict/2798510.4269/ajtmh.17-1020NIH Grants RO1 NS064905, NIH R01 AI052473, U01 AI088752, and R25 TW009338, and the Oswaldo Cruz FoundationUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Postgraduate Program in Health Sciences. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Geral Roberto Santos. Secretaria Estadual da Saúde da Bahia. Salvador, BA, BrasilInstituto Evandro Chagas. Belem, PA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, ConnecticutFor The Salvador Zika Response TeamZika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1-23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.engAmerican Society of Tropical Medicine and HygieneZikaVirus ZikaTransmissãoMicrocefaliaEpilepsiaBrasilCriançasZikaZika VirusTransmissionMicrocephalyEpilepsyBrazilChildrenSeizures as a Complication of Congenital Zika Syndrome in Early Infancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27985/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira-Filho J Seizures as a Complication of Congenital Zika.pdfOliveira-Filho J Seizures as a Complication of Congenital Zika.pdfapplication/pdf82677https://www.arca.fiocruz.br/bitstream/icict/27985/2/Oliveira-Filho%20J%20Seizures%20as%20a%20Complication%20of%20Congenital%20Zika.pdfe67ebd92b967354def5e0e51f9e225c4MD52TEXTOliveira-Filho J Seizures as a Complication of Congenital Zika.pdf.txtOliveira-Filho J Seizures as a Complication of Congenital Zika.pdf.txtExtracted texttext/plain13811https://www.arca.fiocruz.br/bitstream/icict/27985/3/Oliveira-Filho%20J%20Seizures%20as%20a%20Complication%20of%20Congenital%20Zika.pdf.txt30a4572ed3c454385a4b33ac70dcc97aMD53icict/279852023-03-15 14:34:16.652oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| title |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| spellingShingle |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy Oliveira Filho, Jamary Zika Virus Zika Transmissão Microcefalia Epilepsia Brasil Crianças Zika Zika Virus Transmission Microcephaly Epilepsy Brazil Children |
| title_short |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| title_full |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| title_fullStr |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| title_full_unstemmed |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| title_sort |
Seizures as a Complication of Congenital Zika Syndrome in Early Infancy |
| author |
Oliveira Filho, Jamary |
| author_facet |
Oliveira Filho, Jamary Felzemburgh, Ridalva Dias Martins Costa, Federico Nery Júnior, Nivison Ruy Rocha Mattos, Adriana Henriques, Daniele Freitas Ko, Albert Icksang For The Salvador Zika Response Team |
| author_role |
author |
| author2 |
Felzemburgh, Ridalva Dias Martins Costa, Federico Nery Júnior, Nivison Ruy Rocha Mattos, Adriana Henriques, Daniele Freitas Ko, Albert Icksang For The Salvador Zika Response Team |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira Filho, Jamary Felzemburgh, Ridalva Dias Martins Costa, Federico Nery Júnior, Nivison Ruy Rocha Mattos, Adriana Henriques, Daniele Freitas Ko, Albert Icksang For The Salvador Zika Response Team |
| dc.subject.other.pt_BR.fl_str_mv |
Zika Virus Zika Transmissão Microcefalia Epilepsia Brasil Crianças |
| topic |
Zika Virus Zika Transmissão Microcefalia Epilepsia Brasil Crianças Zika Zika Virus Transmission Microcephaly Epilepsy Brazil Children |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Zika Virus Transmission Microcephaly Epilepsy Brazil Children |
| description |
NIH Grants RO1 NS064905, NIH R01 AI052473, U01 AI088752, and R25 TW009338, and the Oswaldo Cruz Foundation |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-08-07T15:44:32Z |
| dc.date.available.fl_str_mv |
2018-08-07T15:44:32Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/27985 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0002-9637 |
| dc.identifier.doi.none.fl_str_mv |
10.4269/ajtmh.17-1020 |
| identifier_str_mv |
OLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018. 0002-9637 10.4269/ajtmh.17-1020 |
| url |
https://www.arca.fiocruz.br/handle/icict/27985 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
| publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/27985/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/27985/2/Oliveira-Filho%20J%20Seizures%20as%20a%20Complication%20of%20Congenital%20Zika.pdf https://www.arca.fiocruz.br/bitstream/icict/27985/3/Oliveira-Filho%20J%20Seizures%20as%20a%20Complication%20of%20Congenital%20Zika.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 e67ebd92b967354def5e0e51f9e225c4 30a4572ed3c454385a4b33ac70dcc97a |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1822792058053591040 |