Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/265597 |
Resumo: | Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic. |
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Faccini, Lavinia SchulerFriedrich, LucianaMoura, Sara Kvitko deSanta Maria, Fernanda DiffiniBone, Steice da Silva Inácio de2023-10-03T03:35:48Z20222405-6502http://hdl.handle.net/10183/265597001175028Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic.application/pdfengeNeurologicalSci. Amsterdam. Vol. 29, (2022), 100417, 6 p.Infecções por CitomegalovirusInfecção por Zika virusEpilepsiaMicrocefaliaCongenital infectionCytomegalovirusEpilepsyZika virusMicrocephalyNeurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infectionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001175028.pdf.txt001175028.pdf.txtExtracted Texttext/plain37583http://www.lume.ufrgs.br/bitstream/10183/265597/2/001175028.pdf.txt15347ad6aeb87911315e35b0faef0332MD52ORIGINAL001175028.pdfTexto completo (inglês)application/pdf358251http://www.lume.ufrgs.br/bitstream/10183/265597/1/001175028.pdfb66f839c2e47344455efc6825ea0d514MD5110183/2655972023-10-04 03:38:53.46055oai:www.lume.ufrgs.br:10183/265597Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-04T06:38:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
title |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
spellingShingle |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection Faccini, Lavinia Schuler Infecções por Citomegalovirus Infecção por Zika virus Epilepsia Microcefalia Congenital infection Cytomegalovirus Epilepsy Zika virus Microcephaly |
title_short |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
title_full |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
title_fullStr |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
title_full_unstemmed |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
title_sort |
Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection |
author |
Faccini, Lavinia Schuler |
author_facet |
Faccini, Lavinia Schuler Friedrich, Luciana Moura, Sara Kvitko de Santa Maria, Fernanda Diffini Bone, Steice da Silva Inácio de |
author_role |
author |
author2 |
Friedrich, Luciana Moura, Sara Kvitko de Santa Maria, Fernanda Diffini Bone, Steice da Silva Inácio de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Faccini, Lavinia Schuler Friedrich, Luciana Moura, Sara Kvitko de Santa Maria, Fernanda Diffini Bone, Steice da Silva Inácio de |
dc.subject.por.fl_str_mv |
Infecções por Citomegalovirus Infecção por Zika virus Epilepsia Microcefalia |
topic |
Infecções por Citomegalovirus Infecção por Zika virus Epilepsia Microcefalia Congenital infection Cytomegalovirus Epilepsy Zika virus Microcephaly |
dc.subject.eng.fl_str_mv |
Congenital infection Cytomegalovirus Epilepsy Zika virus Microcephaly |
description |
Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
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2023-10-03T03:35:48Z |
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eNeurologicalSci. Amsterdam. Vol. 29, (2022), 100417, 6 p. |
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