Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection

Detalhes bibliográficos
Autor(a) principal: Faccini, Lavinia Schuler
Data de Publicação: 2022
Outros Autores: Friedrich, Luciana, Moura, Sara Kvitko de, Santa Maria, Fernanda Diffini, Bone, Steice da Silva Inácio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/265597
Resumo: Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic.
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spelling Faccini, Lavinia SchulerFriedrich, LucianaMoura, Sara Kvitko deSanta Maria, Fernanda DiffiniBone, Steice da Silva Inácio de2023-10-03T03:35:48Z20222405-6502http://hdl.handle.net/10183/265597001175028Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic.application/pdfengeNeurologicalSci. Amsterdam. Vol. 29, (2022), 100417, 6 p.Infecções por CitomegalovirusInfecção por Zika virusEpilepsiaMicrocefaliaCongenital infectionCytomegalovirusEpilepsyZika virusMicrocephalyNeurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infectionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001175028.pdf.txt001175028.pdf.txtExtracted Texttext/plain37583http://www.lume.ufrgs.br/bitstream/10183/265597/2/001175028.pdf.txt15347ad6aeb87911315e35b0faef0332MD52ORIGINAL001175028.pdfTexto completo (inglês)application/pdf358251http://www.lume.ufrgs.br/bitstream/10183/265597/1/001175028.pdfb66f839c2e47344455efc6825ea0d514MD5110183/2655972023-10-04 03:38:53.46055oai:www.lume.ufrgs.br:10183/265597Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-04T06:38:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
title Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
spellingShingle Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
Faccini, Lavinia Schuler
Infecções por Citomegalovirus
Infecção por Zika virus
Epilepsia
Microcefalia
Congenital infection
Cytomegalovirus
Epilepsy
Zika virus
Microcephaly
title_short Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
title_full Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
title_fullStr Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
title_full_unstemmed Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
title_sort Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection
author Faccini, Lavinia Schuler
author_facet Faccini, Lavinia Schuler
Friedrich, Luciana
Moura, Sara Kvitko de
Santa Maria, Fernanda Diffini
Bone, Steice da Silva Inácio de
author_role author
author2 Friedrich, Luciana
Moura, Sara Kvitko de
Santa Maria, Fernanda Diffini
Bone, Steice da Silva Inácio de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Faccini, Lavinia Schuler
Friedrich, Luciana
Moura, Sara Kvitko de
Santa Maria, Fernanda Diffini
Bone, Steice da Silva Inácio de
dc.subject.por.fl_str_mv Infecções por Citomegalovirus
Infecção por Zika virus
Epilepsia
Microcefalia
topic Infecções por Citomegalovirus
Infecção por Zika virus
Epilepsia
Microcefalia
Congenital infection
Cytomegalovirus
Epilepsy
Zika virus
Microcephaly
dc.subject.eng.fl_str_mv Congenital infection
Cytomegalovirus
Epilepsy
Zika virus
Microcephaly
description Introduction: The association between the virus prenatal infection by Zika virus (ZIKV) and central nervous system disorders has been well established and it has been described as the Congenital Syndrome Associated to the Zika Virus (CSZ). However, the neurological development in those patients is still an object of study. The main differential diagnosis is the Cytomegalovirus (CMV). Objective: Describe the involvement of microcephalic patients affected by the congenital infection by the Zika Virus or CMV. Methodology: Data has been collected from microcephalic patients whose birth took place after 2016 and which also had the congenital infection confirmed or presumed. The researched data consists in: congenital infection, head circumference from birth, presence of epilepsy, treatment by mono or polytherapy, electroencephalographic patterns, neurological physical examination and evaluation of gross motor development. Results: 21 microcephalic children have been included showing the following congenital infectious syndromes: 9 were affected by cytomegalovirus (43%), 6 by the Zika virus (29%) and 6 ones by presumed infection due to the Zika virus (29%). From those ones, 13 (62%) presented epilepsy diagnosis including generalized crises and 9 (69%) were in current use of polytherapy. All of them also showed disorganized and asymmetrical base rhythms. Concerning the epileptiform activity, 5 presented multifocal activity and 3 ones hypsarrhythmia. All of the patients went under neuroimaging: 12 (57%) of them presented calcifications and 5 (24%) hydrocephalus. On the neurological exam, 17% presented a decreased axial tone and an enlarged appendicular. Smaller head circumference children had greater motor impairment and severity in the epilepsy. There was no difference in the frequency of epilepsy between children with CSZ and CMV. Conclusion: Epilepsy is confirmed as one of the most important complic.
publishDate 2022
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dc.date.accessioned.fl_str_mv 2023-10-03T03:35:48Z
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dc.relation.ispartof.pt_BR.fl_str_mv eNeurologicalSci. Amsterdam. Vol. 29, (2022), 100417, 6 p.
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