Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56646 |
Resumo: | Secretaria de Estado da Saúde do Maranhão; Departamento de Ciência e Tecnologia do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA). |
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Cavalcante, Tamires BarradasRibeiro, Marizélia Rodrigues CostaSousa, Patrícia da SilvaCosta, Elaine de Paula FiodAlves, Maria Teresa Seabra Soares de Britto eSimões, Vanda Maria FerreiraBatista, Rosângela Fernandes LucenaTakahasi, Eliana Harumi MoriokaAmaral, Gláucio AndradeKhouri, RicardoBranco, Maria dos Remédios Freitas CarvalhoMendes, Ana Karolina TorresCosta, Luciana CavalcanteCampos, Marcos Adriano GarciaSilva, Antônio Augusto Moura da2023-01-26T19:02:14Z2023-01-26T19:02:14Z2022CAVALCANTE, Tamires Barradas et al. Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome. Seizure: European Journal of Epilepsy, v. 103, p. 1-7, 2022.1059-1311https://www.arca.fiocruz.br/handle/icict/5664610.1016/j.seizure.2022.11.001Secretaria de Estado da Saúde do Maranhão; Departamento de Ciência e Tecnologia do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA).Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Medicina III. São Luís, MA, Brasil.Secretaria de Saúde do Estado do Maranhão. Centro de Referência em Neurodesenvolvimento. Assistência e Reabilitação da Criança/NINAR. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Medicina I. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Rede Sarah de Hospitais de Neurorreabilitação. São Luís, MA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Laboratório de Doenças Infecciosas Vetoriais. Salvador, BA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. Programa de Pós-Graduação em Saúde Coletiva. São Luís, MA, Brasil.Objectives: To verify characteristics associated with drug resistant epilepsy in children up to 36 months of age with Congenital Zika Syndrome (CZS). Methods: This is a prospective cohort study with children aged up to 36 months diagnosed with CZS. Obstetric, demographic, phenotype and other clinical signs, cranial tomography, growth and motor development of the children were collected. Results: Of a total of 109 children diagnosed with CZS, 100 (91.7%) had epilepsy and 68 (68%) with drug resistant seizures. The types of seizures associated with drug resistant epilepsy were focal seizures from the occipital lobe, generalized tonic and generalized tonic-clonic seizures. There was an association between drug resistant epilepsy and microcephaly at birth, severe microcephaly at birth, excess nuchal skin, ventriculomegaly, reduced brain parenchyma volume, and hypoplasia or malformation of the cerebellum. Difficulty sleeping, irritability, continuous crying, dysphagia and gross motor function were clinical signs associated with drug resistant epilepsy, as were the presence of ocular abnormalities, low head circumference in the first year of life and low weight in the first six months. Conclusions: The prevalence of drug resistant epilepsy in children up to 36 months with CZS was 62.4% and was associated with the severity of the child's neurological damage, with emphasis on the reduction of brain parenchyma volume and damage to the cerebellum.engElsevierZika vírusMicrocefaliaEpilepsiaZika virusMicrocephalyEpilepsyZika vírusMicrocefaliaEpilepsiaCharacteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56646/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCavalcante,T.B. Characteristics associated...2022.pdfCavalcante,T.B. Characteristics associated...2022.pdfapplication/pdf429044https://www.arca.fiocruz.br/bitstream/icict/56646/2/Cavalcante%2cT.B.%20Characteristics%20associated...2022.pdfa0234a74acf4d41ee02e4fb815f0c5bbMD52icict/566462023-03-15 14:32:50.789oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| title |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| spellingShingle |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome Cavalcante, Tamires Barradas Zika vírus Microcefalia Epilepsia Zika virus Microcephaly Epilepsy Zika vírus Microcefalia Epilepsia |
| title_short |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| title_full |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| title_fullStr |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| title_full_unstemmed |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| title_sort |
Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome |
| author |
Cavalcante, Tamires Barradas |
| author_facet |
Cavalcante, Tamires Barradas Ribeiro, Marizélia Rodrigues Costa Sousa, Patrícia da Silva Costa, Elaine de Paula Fiod Alves, Maria Teresa Seabra Soares de Britto e Simões, Vanda Maria Ferreira Batista, Rosângela Fernandes Lucena Takahasi, Eliana Harumi Morioka Amaral, Gláucio Andrade Khouri, Ricardo Branco, Maria dos Remédios Freitas Carvalho Mendes, Ana Karolina Torres Costa, Luciana Cavalcante Campos, Marcos Adriano Garcia Silva, Antônio Augusto Moura da |
| author_role |
author |
| author2 |
Ribeiro, Marizélia Rodrigues Costa Sousa, Patrícia da Silva Costa, Elaine de Paula Fiod Alves, Maria Teresa Seabra Soares de Britto e Simões, Vanda Maria Ferreira Batista, Rosângela Fernandes Lucena Takahasi, Eliana Harumi Morioka Amaral, Gláucio Andrade Khouri, Ricardo Branco, Maria dos Remédios Freitas Carvalho Mendes, Ana Karolina Torres Costa, Luciana Cavalcante Campos, Marcos Adriano Garcia Silva, Antônio Augusto Moura da |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cavalcante, Tamires Barradas Ribeiro, Marizélia Rodrigues Costa Sousa, Patrícia da Silva Costa, Elaine de Paula Fiod Alves, Maria Teresa Seabra Soares de Britto e Simões, Vanda Maria Ferreira Batista, Rosângela Fernandes Lucena Takahasi, Eliana Harumi Morioka Amaral, Gláucio Andrade Khouri, Ricardo Branco, Maria dos Remédios Freitas Carvalho Mendes, Ana Karolina Torres Costa, Luciana Cavalcante Campos, Marcos Adriano Garcia Silva, Antônio Augusto Moura da |
| dc.subject.other.en_US.fl_str_mv |
Zika vírus Microcefalia Epilepsia |
| topic |
Zika vírus Microcefalia Epilepsia Zika virus Microcephaly Epilepsy Zika vírus Microcefalia Epilepsia |
| dc.subject.en.en_US.fl_str_mv |
Zika virus Microcephaly Epilepsy |
| dc.subject.decs.en_US.fl_str_mv |
Zika vírus Microcefalia Epilepsia |
| description |
Secretaria de Estado da Saúde do Maranhão; Departamento de Ciência e Tecnologia do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA). |
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2022 |
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2022 |
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2023-01-26T19:02:14Z |
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2023-01-26T19:02:14Z |
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info:eu-repo/semantics/article |
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CAVALCANTE, Tamires Barradas et al. Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome. Seizure: European Journal of Epilepsy, v. 103, p. 1-7, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56646 |
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1059-1311 |
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10.1016/j.seizure.2022.11.001 |
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CAVALCANTE, Tamires Barradas et al. Characteristics associated with drug resistant epilepsy in children up to 36 months old with congenital zika syndrome. Seizure: European Journal of Epilepsy, v. 103, p. 1-7, 2022. 1059-1311 10.1016/j.seizure.2022.11.001 |
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Elsevier |
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Elsevier |
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