Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.

Detalhes bibliográficos
Autor(a) principal: Ko, Albert Icksang
Data de Publicação: 2009
Outros Autores: Goarant, Cyrille, Picardeau, Mathieu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12224
Resumo: Weill Medical College of Cornell University. Division of Infectious Disease. New York, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Ko, Albert IcksangGoarant, CyrillePicardeau, Mathieu2015-11-13T12:47:49Z2015-11-13T12:47:49Z2009HO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009.1740-1534https://www.arca.fiocruz.br/handle/icict/1222410.1038/nrmicro2208.engNature Publishing GroupLeptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWeill Medical College of Cornell University. Division of Infectious Disease. New York, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstitut Pasteur de Nouvelle-Calédonie. Laboratoire de Recherche en Bactériologie. Nouméa, New-CaledoniaInstitut Pasteur. Unité de Biologie des Spirochètes. Paris, FranceLeptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.Leptospira/genéticaLeptospira/patogenicidadeLeptospirose/microbiologiaAnimaisVacinas Bacterianas/imunologiaModelos Animais de DoençasGenoma BacterianoHumanosLeptospira/crescimento & desenvolvimentoLeptospira/imunologiaLeptospirose/epidemiologiaLeptospirose/prevenção & controleLeptospirose/transmissãoVirulênciainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12224/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKO AI The dawn of the molecular.....pdfKO AI The dawn of the 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dc.title.pt_BR.fl_str_mv Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
title Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
spellingShingle Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Ko, Albert Icksang
Leptospira/genética
Leptospira/patogenicidade
Leptospirose/microbiologia
Animais
Vacinas Bacterianas/imunologia
Modelos Animais de Doenças
Genoma Bacteriano
Humanos
Leptospira/crescimento & desenvolvimento
Leptospira/imunologia
Leptospirose/epidemiologia
Leptospirose/prevenção & controle
Leptospirose/transmissão
Virulência
title_short Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
title_full Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
title_fullStr Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
title_full_unstemmed Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
title_sort Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
author Ko, Albert Icksang
author_facet Ko, Albert Icksang
Goarant, Cyrille
Picardeau, Mathieu
author_role author
author2 Goarant, Cyrille
Picardeau, Mathieu
author2_role author
author
dc.contributor.author.fl_str_mv Ko, Albert Icksang
Goarant, Cyrille
Picardeau, Mathieu
dc.subject.decs.pt_BR.fl_str_mv Leptospira/genética
Leptospira/patogenicidade
Leptospirose/microbiologia
Animais
Vacinas Bacterianas/imunologia
Modelos Animais de Doenças
Genoma Bacteriano
Humanos
Leptospira/crescimento & desenvolvimento
Leptospira/imunologia
Leptospirose/epidemiologia
Leptospirose/prevenção & controle
Leptospirose/transmissão
Virulência
topic Leptospira/genética
Leptospira/patogenicidade
Leptospirose/microbiologia
Animais
Vacinas Bacterianas/imunologia
Modelos Animais de Doenças
Genoma Bacteriano
Humanos
Leptospira/crescimento & desenvolvimento
Leptospira/imunologia
Leptospirose/epidemiologia
Leptospirose/prevenção & controle
Leptospirose/transmissão
Virulência
description Weill Medical College of Cornell University. Division of Infectious Disease. New York, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-11-13T12:47:49Z
dc.date.available.fl_str_mv 2015-11-13T12:47:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12224
dc.identifier.issn.none.fl_str_mv 1740-1534
dc.identifier.doi.none.fl_str_mv 10.1038/nrmicro2208.
identifier_str_mv HO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009.
1740-1534
10.1038/nrmicro2208.
url https://www.arca.fiocruz.br/handle/icict/12224
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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