Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study

Detalhes bibliográficos
Autor(a) principal: Cunha, Liliane Monteiro
Data de Publicação: 2012
Outros Autores: Bittencourt, Paulo Lisboa, Lemos, Clarice P. Abrantes, Moreira, Agnaluce, Almeida, Delvone, Paraná, Raymundo, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7297
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
id CRUZ_a83932f7b324c2c4162924c6eb16c520
oai_identifier_str oai:www.arca.fiocruz.br:icict/7297
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Cunha, Liliane MonteiroBittencourt, Paulo LisboaLemos, Clarice P. AbrantesMoreira, AgnaluceAlmeida, DelvoneParaná, RaymundoAndrade, Zilton de Araújo2014-02-07T16:38:43Z2014-02-07T16:38:43Z2012CUNHA, L. M. et al. Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology, v.73, n. 1, p. 70-74, 2012.1879-1166https://www.arca.fiocruz.br/handle/icict/7297engElsevierPrevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Portuguese Hospital of Salvador. Salvador, BA, BrasilUniversity of São Paulo School of Medicine. São Paulo, SP, BrasilLPC Laboratory. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilNon-organ-specific autoantibodies (NOSA) are well-recognized diagnostic markers of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), but can also be observed in patients with viral hepatitis as well as in healthy subjects. The aim of this study was to evaluate the prevalence of NOSA in subjects living in a rural community in Brazil and to correlate their occurrence with the presence of liver disease. Seven hundred twenty-five apparently healthy subjects were randomly selected for assessment of antinuclear (ANA), anti-smooth muscle (SMA), antimitochondrial (AMA), anti-liver/kidney microsome type 1, and anti-liver cytosol type 1 antibodies. Subjects with those NOSA were evaluated for the presence of AIH, PBC, and viral hepatitis. Reactivities for all NOSA, SMA, ANA, and AMA were detected, respectively, in 14, 10, 4, and 0.1% of subjects, with a mean titer of 1:40. NOSA-positive subjects were significantly older and more frequently females. No correlation was observed between the occurrence of NOSA and PBC, AIH, or viral hepatitis. The prevalence of NOSA in Brazilians was 14%. They were usually low titer. NOSA were more frequently observed in females and older subjects and their presence was not correlated with the presence of AIH, PBC, or viral hepatitisAutoantibodiesRural populationAutoimmunityAutoimmune diseasesLiver diseasesCirrose Hepática Biliar/imunologiaPopulação Rural/estatística & dados numéricosAnticorpos Antinucleares/imunologiaAdolescenteAdultoIdosoCriançaFemininoTécnica Indireta de Fluorescência para AnticorpoHepatite Autoimune/diagnósticoHepatite Viral Humana/diagnósticoHumanosCirrose Hepática Biliar/diagnósticoMitocôndrias/imunologiaMúsculo Liso/imunologiaPrevalênciaAdulto jovemAutoanticorpos/imunologiaHepatite Autoimune/imunologiaHepatite Viral Humana/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdfCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdfapplication/pdf292661https://www.arca.fiocruz.br/bitstream/icict/7297/1/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdfde73f388fe565caa2ab49f08661d281bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81867https://www.arca.fiocruz.br/bitstream/icict/7297/2/license.txt89d048e714e969a1adcda05fdb1978beMD52TEXTCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdf.txtCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdf.txtExtracted texttext/plain31213https://www.arca.fiocruz.br/bitstream/icict/7297/5/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdf.txta1ee01abe4f58bcb9e717ec1025a736bMD55THUMBNAILCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdf.jpgCunha, LM.; et al. Prevalence of non-organ-specific...Hum Immunol. 2012, p. 70.pdf.jpgGenerated Thumbnailimage/jpeg1935https://www.arca.fiocruz.br/bitstream/icict/7297/4/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdf.jpg61adc96e8eb4f2d02b5e621aaf829226MD54icict/72972023-03-15 14:32:55.819oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
title Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
spellingShingle Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
Cunha, Liliane Monteiro
Autoantibodies
Rural population
Autoimmunity
Autoimmune diseases
Liver diseases
Cirrose Hepática Biliar/imunologia
População Rural/estatística & dados numéricos
Anticorpos Antinucleares/imunologia
Adolescente
Adulto
Idoso
Criança
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Hepatite Autoimune/diagnóstico
Hepatite Viral Humana/diagnóstico
Humanos
Cirrose Hepática Biliar/diagnóstico
Mitocôndrias/imunologia
Músculo Liso/imunologia
Prevalência
Adulto jovem
Autoanticorpos/imunologia
Hepatite Autoimune/imunologia
Hepatite Viral Humana/imunologia
title_short Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
title_full Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
title_fullStr Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
title_full_unstemmed Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
title_sort Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
author Cunha, Liliane Monteiro
author_facet Cunha, Liliane Monteiro
Bittencourt, Paulo Lisboa
Lemos, Clarice P. Abrantes
Moreira, Agnaluce
Almeida, Delvone
Paraná, Raymundo
Andrade, Zilton de Araújo
author_role author
author2 Bittencourt, Paulo Lisboa
Lemos, Clarice P. Abrantes
Moreira, Agnaluce
Almeida, Delvone
Paraná, Raymundo
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Liliane Monteiro
Bittencourt, Paulo Lisboa
Lemos, Clarice P. Abrantes
Moreira, Agnaluce
Almeida, Delvone
Paraná, Raymundo
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Autoantibodies
Rural population
Autoimmunity
Autoimmune diseases
Liver diseases
Cirrose Hepática Biliar/imunologia
População Rural/estatística & dados numéricos
Anticorpos Antinucleares/imunologia
Adolescente
Adulto
Idoso
Criança
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Hepatite Autoimune/diagnóstico
Hepatite Viral Humana/diagnóstico
Humanos
Cirrose Hepática Biliar/diagnóstico
Mitocôndrias/imunologia
Músculo Liso/imunologia
Prevalência
Adulto jovem
topic Autoantibodies
Rural population
Autoimmunity
Autoimmune diseases
Liver diseases
Cirrose Hepática Biliar/imunologia
População Rural/estatística & dados numéricos
Anticorpos Antinucleares/imunologia
Adolescente
Adulto
Idoso
Criança
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Hepatite Autoimune/diagnóstico
Hepatite Viral Humana/diagnóstico
Humanos
Cirrose Hepática Biliar/diagnóstico
Mitocôndrias/imunologia
Músculo Liso/imunologia
Prevalência
Adulto jovem
Autoanticorpos/imunologia
Hepatite Autoimune/imunologia
Hepatite Viral Humana/imunologia
dc.subject.decs.pt_BR.fl_str_mv Autoanticorpos/imunologia
Hepatite Autoimune/imunologia
Hepatite Viral Humana/imunologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-02-07T16:38:43Z
dc.date.available.fl_str_mv 2014-02-07T16:38:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNHA, L. M. et al. Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology, v.73, n. 1, p. 70-74, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7297
dc.identifier.issn.none.fl_str_mv 1879-1166
identifier_str_mv CUNHA, L. M. et al. Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology, v.73, n. 1, p. 70-74, 2012.
1879-1166
url https://www.arca.fiocruz.br/handle/icict/7297
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7297/1/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdf
https://www.arca.fiocruz.br/bitstream/icict/7297/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7297/5/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7297/4/Cunha%2c%20LM.%3b%20et%20al.%20Prevalence%20of%20non-organ-specific...Hum%20Immunol.%202012%2c%20p.%2070.pdf.jpg
bitstream.checksum.fl_str_mv de73f388fe565caa2ab49f08661d281b
89d048e714e969a1adcda05fdb1978be
a1ee01abe4f58bcb9e717ec1025a736b
61adc96e8eb4f2d02b5e621aaf829226
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1822791737738788864

Registros relacionados