Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Detalhes bibliográficos
Autor(a) principal: Damasceno, Patricia Kauanna Fonseca
Data de Publicação: 2020
Outros Autores: Santana, Thaís Alves de, Santos, Girlaine Café, Orge, Iasmim Diniz, Silva, Daniela Nascimento, Albuquerque, Juliana Fonseca, Golinelli, Giulia, Grisendi3, Giulia, Pinelli, Massimo, Santos, Ricardo Ribeiro dos, Dominici, Massimo, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43400
Resumo: Brazilian National Research Council (CNPq)/MS grant number 443909/2018-0 and INOVA/FIOCRUZ grant number VPPIS-001-FIO-18-70.
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spelling Damasceno, Patricia Kauanna FonsecaSantana, Thaís Alves deSantos, Girlaine CaféOrge, Iasmim DinizSilva, Daniela NascimentoAlbuquerque, Juliana FonsecaGolinelli, GiuliaGrisendi3, GiuliaPinelli, MassimoSantos, Ricardo Ribeiro dosDominici, MassimoSoares, Milena Botelho Pereira2020-09-16T14:48:32Z2020-09-16T14:48:32Z2020DAMASCENO, Patricia Kauanna Fonseca et al. Kauanna FonsecaGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine. Frontiers in Cell and Developmental Biology, v. 8, Article 737, p. 1-24, Aug. 2020.2296-634Xhttps://www.arca.fiocruz.br/handle/icict/4340010.3389/fcell.2020.00737Brazilian National Research Council (CNPq)/MS grant number 443909/2018-0 and INOVA/FIOCRUZ grant number VPPIS-001-FIO-18-70.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.University of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Division of Oncology. Modena, Italy.University of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Division of Oncology. Modena, Italy.University of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.Mesenchymal stem/stromal cells (MSCs) have been widely studied in the field of regenerative medicine for applications in the treatment of several disease settings. The therapeutic potential of MSCs has been evaluated in studies in vitro and in vivo, especially based on their anti-inflammatory and pro-regenerative action, through the secretion of soluble mediators. In many cases, however, insufficient engraftment and limited beneficial effects of MSCs indicate the need of approaches to enhance their survival, migration and therapeutic potential. Genetic engineering emerges as a means to induce the expression of different proteins and soluble factors with a wide range of applications, such as growth factors, cytokines, chemokines, transcription factors, enzymes and microRNAs. Distinct strategies have been applied to induce genetic modifications with the goal to enhance the potential of MCSs. This review aims to contribute to the update of the different genetically engineered tools employed for MSCs modification, as well as the factors investigated in different fields in which genetically engineered MSCs have been tested.engFrontiers MediaCélulas-tronco mesenquimaisEngenharia genéticaMedicina regenerativaTerapia celularTerapia de genesCélulas estromaisMesenchymal stemGenetic engineeringRegenerative medicineCell therapyGene therapyStromal cellsGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43400/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDamasceno, Patricia Kauanna Fonseca Genetic....pdfDamasceno, Patricia Kauanna Fonseca Genetic....pdfapplication/pdf577607https://www.arca.fiocruz.br/bitstream/icict/43400/2/Damasceno%2c%20Patricia%20Kauanna%20Fonseca%20Genetic....pdf2d4f574125265a0d632b55aef7dd0022MD52TEXTDamasceno, Patricia Kauanna Fonseca Genetic....pdf.txtDamasceno, Patricia Kauanna Fonseca Genetic....pdf.txtExtracted texttext/plain161992https://www.arca.fiocruz.br/bitstream/icict/43400/3/Damasceno%2c%20Patricia%20Kauanna%20Fonseca%20Genetic....pdf.txt4c41a737fdd4e6431dbb111d78c952e2MD53icict/434002023-03-15 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dc.title.pt_BR.fl_str_mv Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
title Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
spellingShingle Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
Damasceno, Patricia Kauanna Fonseca
Células-tronco mesenquimais
Engenharia genética
Medicina regenerativa
Terapia celular
Terapia de genes
Células estromais
Mesenchymal stem
Genetic engineering
Regenerative medicine
Cell therapy
Gene therapy
Stromal cells
title_short Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
title_full Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
title_fullStr Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
title_full_unstemmed Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
title_sort Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
author Damasceno, Patricia Kauanna Fonseca
author_facet Damasceno, Patricia Kauanna Fonseca
Santana, Thaís Alves de
Santos, Girlaine Café
Orge, Iasmim Diniz
Silva, Daniela Nascimento
Albuquerque, Juliana Fonseca
Golinelli, Giulia
Grisendi3, Giulia
Pinelli, Massimo
Santos, Ricardo Ribeiro dos
Dominici, Massimo
Soares, Milena Botelho Pereira
author_role author
author2 Santana, Thaís Alves de
Santos, Girlaine Café
Orge, Iasmim Diniz
Silva, Daniela Nascimento
Albuquerque, Juliana Fonseca
Golinelli, Giulia
Grisendi3, Giulia
Pinelli, Massimo
Santos, Ricardo Ribeiro dos
Dominici, Massimo
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Damasceno, Patricia Kauanna Fonseca
Santana, Thaís Alves de
Santos, Girlaine Café
Orge, Iasmim Diniz
Silva, Daniela Nascimento
Albuquerque, Juliana Fonseca
Golinelli, Giulia
Grisendi3, Giulia
Pinelli, Massimo
Santos, Ricardo Ribeiro dos
Dominici, Massimo
Soares, Milena Botelho Pereira
dc.subject.other.pt_BR.fl_str_mv Células-tronco mesenquimais
Engenharia genética
Medicina regenerativa
Terapia celular
Terapia de genes
Células estromais
topic Células-tronco mesenquimais
Engenharia genética
Medicina regenerativa
Terapia celular
Terapia de genes
Células estromais
Mesenchymal stem
Genetic engineering
Regenerative medicine
Cell therapy
Gene therapy
Stromal cells
dc.subject.en.pt_BR.fl_str_mv Mesenchymal stem
Genetic engineering
Regenerative medicine
Cell therapy
Gene therapy
Stromal cells
description Brazilian National Research Council (CNPq)/MS grant number 443909/2018-0 and INOVA/FIOCRUZ grant number VPPIS-001-FIO-18-70.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-16T14:48:32Z
dc.date.available.fl_str_mv 2020-09-16T14:48:32Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DAMASCENO, Patricia Kauanna Fonseca et al. Kauanna FonsecaGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine. Frontiers in Cell and Developmental Biology, v. 8, Article 737, p. 1-24, Aug. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43400
dc.identifier.issn.pt_BR.fl_str_mv 2296-634X
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fcell.2020.00737
identifier_str_mv DAMASCENO, Patricia Kauanna Fonseca et al. Kauanna FonsecaGenetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine. Frontiers in Cell and Developmental Biology, v. 8, Article 737, p. 1-24, Aug. 2020.
2296-634X
10.3389/fcell.2020.00737
url https://www.arca.fiocruz.br/handle/icict/43400
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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