Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45977 |
Resumo: | Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP. |
id |
CRUZ_922035d0ce3e8f21328438c0d664e921 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/45977 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Golinelli, GiuliaMastrolia, IleniaAramini, BeatriceMasciale, ValentinaPinelli, MassimoPacchioni, LucreziaCasari, GiuliaDall’Ora, MassimilianoSoares, Milena Botelho PereiraDamasceno, Patrícia Kauanna FonsecaSilva, Daniela NascimentoDominici, MassimoGrisendi, Giulia2021-02-06T14:06:43Z2021-02-06T14:06:43Z2020GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020.1663-9812https://www.arca.fiocruz.br/handle/icict/4597710.3389/fphar.2020.529921Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Thoracic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Thoracic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy / Rigenerand srl,.Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy / Rigenerand srl,.Modena, Italy.Since mesenchymal stromal/stem cells (MSCs) were discovered, researchers have been drawn to study their peculiar biological features, including their immune privileged status and their capacity to selectively migrate into inflammatory areas, including tumors. These properties make MSCs promising cellular vehicles for the delivery of therapeutic molecules in the clinical setting. In recent decades, the engineering of MSCs into biological vehicles carrying anticancer compounds has been achieved in different ways, including the loading of MSCs with chemotherapeutics or drug functionalized nanoparticles (NPs), genetic modifications to force the production of anticancer proteins, and the use of oncolytic viruses. Recently, it has been demonstrated that wild-type and engineered MSCs can release extracellular vesicles (EVs) that contain therapeutic agents. Despite the enthusiasm for MSCs as cyto-pharmaceutical agents, many challenges, including controlling the fate of MSCs after administration, must still be considered. Preclinical results demonstrated that MSCs accumulate in lung, liver, and spleen, which could prevent their engraftment into tumor sites. For this reason, physical, physiological, and biological methods have been implemented to increase MSC concentration in the target tumors. Currently, there are more than 900 registered clinical trials using MSCs. Only a small fraction of these are investigating MSC-based therapies for cancer, but the number of these clinical trials is expected to increase as technology and our understanding of MSCs improve. This review will summarize MSC-based antitumor therapies to generate an increasing awareness of their potential and limits to accelerate their clinical translation.engFrontiers Research FoundationCélulas-Tronco MesenquimaisCâncerCitocina TWEAKTerapia genéticaTerapia celularMesenchymal stromal/stem cellCancerTumor necrosis factor-related apoptosis-inducing ligand,Gene therapyCell therapyArming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45977/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdfGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdfapplication/pdf2111873https://www.arca.fiocruz.br/bitstream/icict/45977/2/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdfad4a20e497d07f945496b7debdd2773cMD52TEXTGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdf.txtGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdf.txtExtracted texttext/plain90871https://www.arca.fiocruz.br/bitstream/icict/45977/3/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf.txtb56605eaa862f165c667e7a1103b6ee5MD53icict/459772023-03-15 14:34:29.313oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
title |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
spellingShingle |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Golinelli, Giulia Células-Tronco Mesenquimais Câncer Citocina TWEAK Terapia genética Terapia celular Mesenchymal stromal/stem cell Cancer Tumor necrosis factor-related apoptosis-inducing ligand, Gene therapy Cell therapy |
title_short |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
title_full |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
title_fullStr |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
title_full_unstemmed |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
title_sort |
Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? |
author |
Golinelli, Giulia |
author_facet |
Golinelli, Giulia Mastrolia, Ilenia Aramini, Beatrice Masciale, Valentina Pinelli, Massimo Pacchioni, Lucrezia Casari, Giulia Dall’Ora, Massimiliano Soares, Milena Botelho Pereira Damasceno, Patrícia Kauanna Fonseca Silva, Daniela Nascimento Dominici, Massimo Grisendi, Giulia |
author_role |
author |
author2 |
Mastrolia, Ilenia Aramini, Beatrice Masciale, Valentina Pinelli, Massimo Pacchioni, Lucrezia Casari, Giulia Dall’Ora, Massimiliano Soares, Milena Botelho Pereira Damasceno, Patrícia Kauanna Fonseca Silva, Daniela Nascimento Dominici, Massimo Grisendi, Giulia |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Golinelli, Giulia Mastrolia, Ilenia Aramini, Beatrice Masciale, Valentina Pinelli, Massimo Pacchioni, Lucrezia Casari, Giulia Dall’Ora, Massimiliano Soares, Milena Botelho Pereira Damasceno, Patrícia Kauanna Fonseca Silva, Daniela Nascimento Dominici, Massimo Grisendi, Giulia |
dc.subject.other.pt_BR.fl_str_mv |
Células-Tronco Mesenquimais Câncer Citocina TWEAK Terapia genética Terapia celular |
topic |
Células-Tronco Mesenquimais Câncer Citocina TWEAK Terapia genética Terapia celular Mesenchymal stromal/stem cell Cancer Tumor necrosis factor-related apoptosis-inducing ligand, Gene therapy Cell therapy |
dc.subject.en.pt_BR.fl_str_mv |
Mesenchymal stromal/stem cell Cancer Tumor necrosis factor-related apoptosis-inducing ligand, Gene therapy Cell therapy |
description |
Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-02-06T14:06:43Z |
dc.date.available.fl_str_mv |
2021-02-06T14:06:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45977 |
dc.identifier.issn.pt_BR.fl_str_mv |
1663-9812 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fphar.2020.529921 |
identifier_str_mv |
GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020. 1663-9812 10.3389/fphar.2020.529921 |
url |
https://www.arca.fiocruz.br/handle/icict/45977 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Research Foundation |
publisher.none.fl_str_mv |
Frontiers Research Foundation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/45977/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/45977/2/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf https://www.arca.fiocruz.br/bitstream/icict/45977/3/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf.txt |
bitstream.checksum.fl_str_mv |
36b51ef91c52b5338d9d29ba0cc807bc ad4a20e497d07f945496b7debdd2773c b56605eaa862f165c667e7a1103b6ee5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813009144688410624 |