Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene

Detalhes bibliográficos
Autor(a) principal: Costa, Giselle Calasans de Souza
Data de Publicação: 2009
Outros Autores: Azevedo, Rochele, Gadelha, Sandra Rocha, Kashima, Simone Haddad, Muricy, Gabriel, Gallazzi, Viviana Nilla Olavarria, Covas, Dimas Tadeu, Takayanagui, Osvaldo Massaiti, Castro Filho, Bernardo Galvão, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1892
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
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spelling Costa, Giselle Calasans de SouzaAzevedo, RocheleGadelha, Sandra RochaKashima, Simone HaddadMuricy, GabrielGallazzi, Viviana Nilla OlavarriaCovas, Dimas TadeuTakayanagui, Osvaldo MassaitiCastro Filho, Bernardo GalvãoAlcantara, Luiz Carlos Júnior2011-04-12T23:14:32Z2011-04-12T23:14:32Z2009COSTA, G. C. S. et al. Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene. Journal of Medical Virology, v. 81, n. 3, p. 552-557, 2009.0146-6615https://www.arca.fiocruz.br/handle/icict/189210.1002/jmv.21421engPolymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 geneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHemocentro de Ribeirão Preto. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHemocentro de Ribeirão Preto. São Paulo, SP, BrasilFundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHemocentro de Ribeirão Preto. São Paulo, SP, BrasilUniversidade de São Faculdade de Medicina de Ribeirão Preto. Psiquiatria e Psicologia Médica. Departamento de Neurologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilThe development of HTLV-1 associated clinical manifestations, such as TSP/HAM and ATLL, occur in 2-4% of the infected population and it is still unclear why this infection remains asymptomatic in most infected carriers. Recently, it has been demonstrated that HTLV uses the Glucose transporter type 1 (GLUT1) to infect T-CD4(+) lymphocytes and that single nucleotide polymorphisms (SNP) in the GLUT1 gene are associated with diabetic nephropathy in patients with diabetes mellitus in different populations. These polymorphisms could contribute to a higher GLUT1 protein expression on cellular membrane, facilitating the entry of HTLV and its transmission cell by cell. This could result in a higher provirus load and consequently in the development of TSP/HAM. To evaluate the role of GLUT1 gene polymorphisms in the development of TSP/HAM in HTLV-1 infected individuals, the g.22999G > T, g.15339T > C and c.-2841A > T sites were analyzed by PCR/RFLP or sequencing in 244 infected individuals and 102 normal controls. The proviral load of the HTLV-1 infected patients was also analyzed using Real Time Quantitative PCR. Genotypic and allelic frequencies of the three sites did not differ significantly between controls and HTLV-1 infected individuals. There was no difference in genotypic and allelic distributions among patients as to the presence or absence of HTLV-1 associated clinic manifestations. As regards the quantification of the provirus load, we observed a significant reduction in the asymptomatic individuals compared with the oligosymptomatic and TSP/HAM individuals. These results suggest that g.22999G > T, g.15339T > C, and c.-2841A > T SNP do not contribute to HTLV-1 infection nor to the genetic susceptibility of TSP/HAM in Brazilian HTLV-1 infected individuals.HTLV-1GLUT1PolymorphismsTransportador de Glucose Tipo 1Infecções por HTLV-IVirus Linfotrópico de Células T Humanas Tipo 1Paraparesia Espástica TropicalPolimorfismo Genéticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPolymorphisms at GLUT1 Gene.pdfPolymorphisms at GLUT1 Gene.pdfapplication/pdf108423https://www.arca.fiocruz.br/bitstream/icict/1892/1/Polymorphisms%20at%20GLUT1%20Gene.pdf6e787c1203088124df6750271c956cafMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1892/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTPolymorphisms at GLUT1 Gene.pdf.txtPolymorphisms at GLUT1 Gene.pdf.txtExtracted texttext/plain30988https://www.arca.fiocruz.br/bitstream/icict/1892/5/Polymorphisms%20at%20GLUT1%20Gene.pdf.txte5846226509d84b018481708259b3a1bMD55THUMBNAILPolymorphisms at GLUT1 Gene.pdf.jpgPolymorphisms at GLUT1 Gene.pdf.jpgGenerated Thumbnailimage/jpeg2543https://www.arca.fiocruz.br/bitstream/icict/1892/4/Polymorphisms%20at%20GLUT1%20Gene.pdf.jpge67f110fb4761847fa59bd808311d984MD54icict/18922023-03-15 14:32:56.13oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
title Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
spellingShingle Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
Costa, Giselle Calasans de Souza
HTLV-1
GLUT1
Polymorphisms
Transportador de Glucose Tipo 1
Infecções por HTLV-I
Virus Linfotrópico de Células T Humanas Tipo 1
Paraparesia Espástica Tropical
Polimorfismo Genético
title_short Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
title_full Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
title_fullStr Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
title_full_unstemmed Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
title_sort Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene
author Costa, Giselle Calasans de Souza
author_facet Costa, Giselle Calasans de Souza
Azevedo, Rochele
Gadelha, Sandra Rocha
Kashima, Simone Haddad
Muricy, Gabriel
Gallazzi, Viviana Nilla Olavarria
Covas, Dimas Tadeu
Takayanagui, Osvaldo Massaiti
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author_role author
author2 Azevedo, Rochele
Gadelha, Sandra Rocha
Kashima, Simone Haddad
Muricy, Gabriel
Gallazzi, Viviana Nilla Olavarria
Covas, Dimas Tadeu
Takayanagui, Osvaldo Massaiti
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Giselle Calasans de Souza
Azevedo, Rochele
Gadelha, Sandra Rocha
Kashima, Simone Haddad
Muricy, Gabriel
Gallazzi, Viviana Nilla Olavarria
Covas, Dimas Tadeu
Takayanagui, Osvaldo Massaiti
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
dc.subject.en.pt_BR.fl_str_mv HTLV-1
GLUT1
Polymorphisms
topic HTLV-1
GLUT1
Polymorphisms
Transportador de Glucose Tipo 1
Infecções por HTLV-I
Virus Linfotrópico de Células T Humanas Tipo 1
Paraparesia Espástica Tropical
Polimorfismo Genético
dc.subject.decs.pt_BR.fl_str_mv Transportador de Glucose Tipo 1
Infecções por HTLV-I
Virus Linfotrópico de Células T Humanas Tipo 1
Paraparesia Espástica Tropical
Polimorfismo Genético
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-12T23:14:32Z
dc.date.available.fl_str_mv 2011-04-12T23:14:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, G. C. S. et al. Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene. Journal of Medical Virology, v. 81, n. 3, p. 552-557, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1892
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.21421
identifier_str_mv COSTA, G. C. S. et al. Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene. Journal of Medical Virology, v. 81, n. 3, p. 552-557, 2009.
0146-6615
10.1002/jmv.21421
url https://www.arca.fiocruz.br/handle/icict/1892
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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