Bone marrow-derived cells as a therapeutic approach to optic nerve diseases

Detalhes bibliográficos
Autor(a) principal: Mesentier-Louro, Louise A.
Data de Publicação: 2016
Outros Autores: Zaverucha-do-Valle, Camila, Rosado-de-Castro, Paulo H., Silva-Junior, Almir J., Pimentel-Coelho, Pedro M., Mendez-Otero, Rosalia, Santiago, Marcelo F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31843
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
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spelling Mesentier-Louro, Louise A.Zaverucha-do-Valle, CamilaRosado-de-Castro, Paulo H.Silva-Junior, Almir J.Pimentel-Coelho, Pedro M.Mendez-Otero, RosaliaSantiago, Marcelo F.2019-02-22T13:53:00Z2019-02-22T13:53:00Z2016MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016.1687-966Xhttps://www.arca.fiocruz.br/handle/icict/3184310.1155/2016/50786191687-9678engHindawi Publishing CorporationBone marrow-derived cells as a therapeutic approach to optic nerve diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Following optic nerve injury associated with acute or progressive diseases, retinal ganglion cells (RGCs) of adult mammals degenerate and undergo apoptosis. These diseases have limited therapeutic options, due to the low inherent capacity of RGCs to regenerate and due to the inhibitory milieu of the central nervous system. Among the numerous treatment approaches investigated to stimulate neuronal survival and axonal extension, cell transplantation emerges as a promising option. This review focuses on cell therapies with bone marrow mononuclear cells and bone marrow-derived mesenchymal stem cells, which have shown positive therapeutic effects in animal models of optic neuropathies. Different aspects of available preclinical studies are analyzed, including cell distribution, potential doses, routes of administration, and mechanisms of action. Finally, published and ongoing clinical trials are summarized.Bone marrow-derived cellsOptic nerve diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31843/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Mesentier-Louro_Louise_etal_INI_2016.pdfve_Mesentier-Louro_Louise_etal_INI_2016.pdfapplication/pdf1312382https://www.arca.fiocruz.br/bitstream/icict/31843/2/ve_Mesentier-Louro_Louise_etal_INI_2016.pdf24a4c20038aa767b1874623fee10dc72MD52TEXTve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txtve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txtExtracted texttext/plain94189https://www.arca.fiocruz.br/bitstream/icict/31843/3/ve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txt2e89fca652d6efce73fe24e93b4bd904MD53icict/318432019-02-23 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dc.title.pt_BR.fl_str_mv Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
title Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
spellingShingle Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
Mesentier-Louro, Louise A.
Bone marrow-derived cells
Optic nerve diseases
title_short Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
title_full Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
title_fullStr Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
title_full_unstemmed Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
title_sort Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
author Mesentier-Louro, Louise A.
author_facet Mesentier-Louro, Louise A.
Zaverucha-do-Valle, Camila
Rosado-de-Castro, Paulo H.
Silva-Junior, Almir J.
Pimentel-Coelho, Pedro M.
Mendez-Otero, Rosalia
Santiago, Marcelo F.
author_role author
author2 Zaverucha-do-Valle, Camila
Rosado-de-Castro, Paulo H.
Silva-Junior, Almir J.
Pimentel-Coelho, Pedro M.
Mendez-Otero, Rosalia
Santiago, Marcelo F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mesentier-Louro, Louise A.
Zaverucha-do-Valle, Camila
Rosado-de-Castro, Paulo H.
Silva-Junior, Almir J.
Pimentel-Coelho, Pedro M.
Mendez-Otero, Rosalia
Santiago, Marcelo F.
dc.subject.en.pt_BR.fl_str_mv Bone marrow-derived cells
Optic nerve diseases
topic Bone marrow-derived cells
Optic nerve diseases
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-02-22T13:53:00Z
dc.date.available.fl_str_mv 2019-02-22T13:53:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31843
dc.identifier.issn.pt_BR.fl_str_mv 1687-966X
dc.identifier.doi.none.fl_str_mv 10.1155/2016/5078619
dc.identifier.eissn.none.fl_str_mv 1687-9678
identifier_str_mv MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016.
1687-966X
10.1155/2016/5078619
1687-9678
url https://www.arca.fiocruz.br/handle/icict/31843
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31843/1/license.txt
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