Bone marrow-derived cells as a therapeutic approach to optic nerve diseases
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31843 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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Mesentier-Louro, Louise A.Zaverucha-do-Valle, CamilaRosado-de-Castro, Paulo H.Silva-Junior, Almir J.Pimentel-Coelho, Pedro M.Mendez-Otero, RosaliaSantiago, Marcelo F.2019-02-22T13:53:00Z2019-02-22T13:53:00Z2016MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016.1687-966Xhttps://www.arca.fiocruz.br/handle/icict/3184310.1155/2016/50786191687-9678engHindawi Publishing CorporationBone marrow-derived cells as a therapeutic approach to optic nerve diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Following optic nerve injury associated with acute or progressive diseases, retinal ganglion cells (RGCs) of adult mammals degenerate and undergo apoptosis. These diseases have limited therapeutic options, due to the low inherent capacity of RGCs to regenerate and due to the inhibitory milieu of the central nervous system. Among the numerous treatment approaches investigated to stimulate neuronal survival and axonal extension, cell transplantation emerges as a promising option. This review focuses on cell therapies with bone marrow mononuclear cells and bone marrow-derived mesenchymal stem cells, which have shown positive therapeutic effects in animal models of optic neuropathies. Different aspects of available preclinical studies are analyzed, including cell distribution, potential doses, routes of administration, and mechanisms of action. Finally, published and ongoing clinical trials are summarized.Bone marrow-derived cellsOptic nerve diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31843/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Mesentier-Louro_Louise_etal_INI_2016.pdfve_Mesentier-Louro_Louise_etal_INI_2016.pdfapplication/pdf1312382https://www.arca.fiocruz.br/bitstream/icict/31843/2/ve_Mesentier-Louro_Louise_etal_INI_2016.pdf24a4c20038aa767b1874623fee10dc72MD52TEXTve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txtve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txtExtracted texttext/plain94189https://www.arca.fiocruz.br/bitstream/icict/31843/3/ve_Mesentier-Louro_Louise_etal_INI_2016.pdf.txt2e89fca652d6efce73fe24e93b4bd904MD53icict/318432019-02-23 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dc.title.pt_BR.fl_str_mv |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
title |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
spellingShingle |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases Mesentier-Louro, Louise A. Bone marrow-derived cells Optic nerve diseases |
title_short |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
title_full |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
title_fullStr |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
title_full_unstemmed |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
title_sort |
Bone marrow-derived cells as a therapeutic approach to optic nerve diseases |
author |
Mesentier-Louro, Louise A. |
author_facet |
Mesentier-Louro, Louise A. Zaverucha-do-Valle, Camila Rosado-de-Castro, Paulo H. Silva-Junior, Almir J. Pimentel-Coelho, Pedro M. Mendez-Otero, Rosalia Santiago, Marcelo F. |
author_role |
author |
author2 |
Zaverucha-do-Valle, Camila Rosado-de-Castro, Paulo H. Silva-Junior, Almir J. Pimentel-Coelho, Pedro M. Mendez-Otero, Rosalia Santiago, Marcelo F. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mesentier-Louro, Louise A. Zaverucha-do-Valle, Camila Rosado-de-Castro, Paulo H. Silva-Junior, Almir J. Pimentel-Coelho, Pedro M. Mendez-Otero, Rosalia Santiago, Marcelo F. |
dc.subject.en.pt_BR.fl_str_mv |
Bone marrow-derived cells Optic nerve diseases |
topic |
Bone marrow-derived cells Optic nerve diseases |
description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-02-22T13:53:00Z |
dc.date.available.fl_str_mv |
2019-02-22T13:53:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31843 |
dc.identifier.issn.pt_BR.fl_str_mv |
1687-966X |
dc.identifier.doi.none.fl_str_mv |
10.1155/2016/5078619 |
dc.identifier.eissn.none.fl_str_mv |
1687-9678 |
identifier_str_mv |
MESENTIER-LOURO, Louise A. et al. Bone marrow-derived cells as a therapeutic approach to optic nerve diseases. Stem Cells International, v. 2016, p. 1-16, 2016. 1687-966X 10.1155/2016/5078619 1687-9678 |
url |
https://www.arca.fiocruz.br/handle/icict/31843 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
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