Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57856 https://doi.org/10.1080/23723556.2023.2188858 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. |
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Zanette, Dalila LuciolaCoelho, Karoline Brito Caetano AndradeCarvalho, Eneas deAoki, Mateus NobregaNardin, Jeanine MarieLalli, Larissa AraújoBezerra, Rafael dos SantosGiovanetti, MartaZucherato, Victória SimionattoCampos, Gabriel Montenegro deBernardino, Jardelina de Souza TodãoViala, Vincent LouisCiccozzi, MassimoAlcantara, Luiz Carlos JuniorSampaio, Sandra CoccuzzoElias, Maria CarolinaKashima, SimoneCovas, Dimas TadeuSlavov, Svetoslav Nanev2023-04-18T20:16:42Z2023-04-18T20:16:42Z2023ZANETTE, Dalila Luciola et al. Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer. Molecular & Cellular Oncology, v. 10, n. 1, p. 1-10, 2023.2372-3556https://www.arca.fiocruz.br/handle/icict/57856https://doi.org/10.1080/23723556.2023.2188858porTaylor and FrancisCâncer da PróstataViromeProstatic NeoplasmsMetagenomicsVirusesMolecular Sequence DataViromaNeoplasias de la PróstataMetagenómicaVirusDatos de Secuencia MolecularTumeurs de la prostateMétagénomiqueVirusDonnées de séquences moléculairesViromaNeoplasias da PróstataMetagenômicaVírusDados de Sequência MolecularMetagenomic insights into the plasma virome of Brazilian patients with prostate cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Ribeirão Preto, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Hospital Erasto Gaertner. Departamento de Urologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Rome, Italy. / Fundação Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil.Epidemiology and Statistic Unit. University of Campus Bio-Medico di Roma. Rome, Italy.Fundação Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Instituto Butantan. São Paulo, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil. / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Instituto Butantan. São Paulo, SP, Brasil. / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Growing evidence suggests that metavirome changes could be associated increased risk for malignant cell transformation. Considering Viruses have been proposed as factors for prostate cancer induction. The objective of this study was to examine the composition of the plasma metavirome of patients with prostate cancer. Blood samples were obtained from 49 male patients with primary prostate adenocarcinoma. Thirty blood donors were included as a control group. The obtained next-generation sequencing data were analyzed using a bioinformatic pipeline for virus metagenomics. Viral reads with higher abundance were assembled in contigs and analyzed taxonomically. Viral agents of interest were also confirmed by qPCR. Anelloviruses and the Human Pegivirus-1 (HPgV-1) were the most abundant component of plasma metavirome. Clinically important viruses like hepatitis C virus (HCV), cytomegalovirus and human adenovirus type C were also identified. In comparison, the blood donor virome was exclusively composed of torque teno virus types (TTV) types. The performed HPgV-1 and HCV phylogeny revealed that these viruses belong to commonly detected in Brazil genotypes. Our study sheds light on the plasma viral abundance in patients with prostatic cancer. The obtained viral diversity allowed us to separate the patients and controls, probably suggesting that malignant processes may influence virome composition. More complex and multiple approach investigations are necessary to examine the likely causal relationship between metavirome and its involvement in prostate cancer.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57856/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMetagenomic_virome_OK.pdfMetagenomic_virome_OK.pdfapplication/pdf2425833https://www.arca.fiocruz.br/bitstream/icict/57856/2/Metagenomic_virome_OK.pdf0639b2efa9e2de621e58c8223450d74eMD52icict/578562023-04-18 17:16:42.98oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-18T20:16:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| title |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| spellingShingle |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer Zanette, Dalila Luciola Câncer da Próstata Virome Prostatic Neoplasms Metagenomics Viruses Molecular Sequence Data Viroma Neoplasias de la Próstata Metagenómica Virus Datos de Secuencia Molecular Tumeurs de la prostate Métagénomique Virus Données de séquences moléculaires Viroma Neoplasias da Próstata Metagenômica Vírus Dados de Sequência Molecular |
| title_short |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| title_full |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| title_fullStr |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| title_full_unstemmed |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| title_sort |
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer |
| author |
Zanette, Dalila Luciola |
| author_facet |
Zanette, Dalila Luciola Coelho, Karoline Brito Caetano Andrade Carvalho, Eneas de Aoki, Mateus Nobrega Nardin, Jeanine Marie Lalli, Larissa Araújo Bezerra, Rafael dos Santos Giovanetti, Marta Zucherato, Victória Simionatto Campos, Gabriel Montenegro de Bernardino, Jardelina de Souza Todão Viala, Vincent Louis Ciccozzi, Massimo Alcantara, Luiz Carlos Junior Sampaio, Sandra Coccuzzo Elias, Maria Carolina Kashima, Simone Covas, Dimas Tadeu Slavov, Svetoslav Nanev |
| author_role |
author |
| author2 |
Coelho, Karoline Brito Caetano Andrade Carvalho, Eneas de Aoki, Mateus Nobrega Nardin, Jeanine Marie Lalli, Larissa Araújo Bezerra, Rafael dos Santos Giovanetti, Marta Zucherato, Victória Simionatto Campos, Gabriel Montenegro de Bernardino, Jardelina de Souza Todão Viala, Vincent Louis Ciccozzi, Massimo Alcantara, Luiz Carlos Junior Sampaio, Sandra Coccuzzo Elias, Maria Carolina Kashima, Simone Covas, Dimas Tadeu Slavov, Svetoslav Nanev |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Zanette, Dalila Luciola Coelho, Karoline Brito Caetano Andrade Carvalho, Eneas de Aoki, Mateus Nobrega Nardin, Jeanine Marie Lalli, Larissa Araújo Bezerra, Rafael dos Santos Giovanetti, Marta Zucherato, Victória Simionatto Campos, Gabriel Montenegro de Bernardino, Jardelina de Souza Todão Viala, Vincent Louis Ciccozzi, Massimo Alcantara, Luiz Carlos Junior Sampaio, Sandra Coccuzzo Elias, Maria Carolina Kashima, Simone Covas, Dimas Tadeu Slavov, Svetoslav Nanev |
| dc.subject.other.en_US.fl_str_mv |
Câncer da Próstata |
| topic |
Câncer da Próstata Virome Prostatic Neoplasms Metagenomics Viruses Molecular Sequence Data Viroma Neoplasias de la Próstata Metagenómica Virus Datos de Secuencia Molecular Tumeurs de la prostate Métagénomique Virus Données de séquences moléculaires Viroma Neoplasias da Próstata Metagenômica Vírus Dados de Sequência Molecular |
| dc.subject.en.en_US.fl_str_mv |
Virome Prostatic Neoplasms Metagenomics Viruses Molecular Sequence Data |
| dc.subject.es.en_US.fl_str_mv |
Viroma Neoplasias de la Próstata Metagenómica Virus Datos de Secuencia Molecular |
| dc.subject.fr.en_US.fl_str_mv |
Tumeurs de la prostate Métagénomique Virus Données de séquences moléculaires |
| dc.subject.decs.en_US.fl_str_mv |
Viroma Neoplasias da Próstata Metagenômica Vírus Dados de Sequência Molecular |
| description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. |
| publishDate |
2023 |
| dc.date.accessioned.fl_str_mv |
2023-04-18T20:16:42Z |
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2023-04-18T20:16:42Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ZANETTE, Dalila Luciola et al. Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer. Molecular & Cellular Oncology, v. 10, n. 1, p. 1-10, 2023. |
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https://www.arca.fiocruz.br/handle/icict/57856 |
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2372-3556 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1080/23723556.2023.2188858 |
| identifier_str_mv |
ZANETTE, Dalila Luciola et al. Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer. Molecular & Cellular Oncology, v. 10, n. 1, p. 1-10, 2023. 2372-3556 |
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https://www.arca.fiocruz.br/handle/icict/57856 https://doi.org/10.1080/23723556.2023.2188858 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Taylor and Francis |
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Taylor and Francis |
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