Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia

Detalhes bibliográficos
Autor(a) principal: Totino, Paulo Renato Rivas
Data de Publicação: 2011
Outros Autores: Daniel-Ribeiro, Cláudio Tadeu, Cruz, Maria de Fátima Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15040
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
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spelling Totino, Paulo Renato RivasDaniel-Ribeiro, Cláudio TadeuCruz, Maria de Fátima Ferreira da2016-07-21T15:03:55Z2016-07-21T15:03:55Z2011TOTINO, Paulo Renato Rivas; DANIEL-RIBEIRO, Cláudio Tadeu; CRUZ, Maria de Fátima Ferreira da. Refractoriness of eryptotic red blood Cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia. Plos One, v. 6, n.10, p. 1-5, Oct. 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/1504010.1371/journal.pone.0026575engPublic Library of SciencePlasmodium falciparumEritrócitosMaláriaPatogênese da maláriaPlasmodium falciparumParasitaemiaRed Blood CellsMalariaMalaria pathogenesisMaláriaEritrócitosPlasmodium falciparumRefractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Recently, we have described that apoptosis-like process of red blood cells (RBC) - eryptosis - in malaria is not restricted to parasitized cells, occurring also in non-parasitized RBC (nRBC). Besides to pathogenic proprieties, apoptosis also participates in the innate defense trough restriction of intracellular pathogens propagation. In the present study, we investigated the capacity of P. falciparum parasites to infect eryptotic RBC. Schizont parasitized RBC concentrated by magnetic separation were cultured with eryptotic RBC obtained by ionomycin treatment and, then, parasite growth was evaluated in Giemsa-stained thin blood smears. While parasites infected and developed normally in control non-eryptotic RBC, cultures performed with eryptotic RBC had a marked decrease in parasitaemia. It was noteworthy a great number of free merozoites in eryptotic RBC cultures, indicating that these cells were not susceptible to invasion. We suggest that although eryptosis could be involved in malaria pathogenesis, it could also acting protectively by controlling parasite propagation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15040/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpaulo_totino_etal_IOC_2011.pdfpaulo_totino_etal_IOC_2011.pdfapplication/pdf1835943https://www.arca.fiocruz.br/bitstream/icict/15040/2/paulo_totino_etal_IOC_2011.pdf56d5e0788cebe79b1732e349d7a4c7e0MD52TEXTpaulo_totino_etal_IOC_2011.pdf.txtpaulo_totino_etal_IOC_2011.pdf.txtExtracted texttext/plain20551https://www.arca.fiocruz.br/bitstream/icict/15040/3/paulo_totino_etal_IOC_2011.pdf.txt9f0b8a5f8d0962f68219b1eb8219e00fMD53icict/150402018-12-28 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dc.title.pt_BR.fl_str_mv Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
title Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
spellingShingle Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
Totino, Paulo Renato Rivas
Plasmodium falciparum
Eritrócitos
Malária
Patogênese da malária
Plasmodium falciparum
Parasitaemia
Red Blood Cells
Malaria
Malaria pathogenesis
Malária
Eritrócitos
Plasmodium falciparum
title_short Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
title_full Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
title_fullStr Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
title_full_unstemmed Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
title_sort Refractoriness of eryptotic red blood cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia
author Totino, Paulo Renato Rivas
author_facet Totino, Paulo Renato Rivas
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author2_role author
author
dc.contributor.author.fl_str_mv Totino, Paulo Renato Rivas
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
dc.subject.other.pt_BR.fl_str_mv Plasmodium falciparum
Eritrócitos
Malária
Patogênese da malária
topic Plasmodium falciparum
Eritrócitos
Malária
Patogênese da malária
Plasmodium falciparum
Parasitaemia
Red Blood Cells
Malaria
Malaria pathogenesis
Malária
Eritrócitos
Plasmodium falciparum
dc.subject.en.pt_BR.fl_str_mv Plasmodium falciparum
Parasitaemia
Red Blood Cells
Malaria
Malaria pathogenesis
dc.subject.decs.pt_BR.fl_str_mv Malária
Eritrócitos
Plasmodium falciparum
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-07-21T15:03:55Z
dc.date.available.fl_str_mv 2016-07-21T15:03:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOTINO, Paulo Renato Rivas; DANIEL-RIBEIRO, Cláudio Tadeu; CRUZ, Maria de Fátima Ferreira da. Refractoriness of eryptotic red blood Cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia. Plos One, v. 6, n.10, p. 1-5, Oct. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15040
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0026575
identifier_str_mv TOTINO, Paulo Renato Rivas; DANIEL-RIBEIRO, Cláudio Tadeu; CRUZ, Maria de Fátima Ferreira da. Refractoriness of eryptotic red blood Cells to Plasmodium falciparum infection: a putative host defense mechanism limiting parasitaemia. Plos One, v. 6, n.10, p. 1-5, Oct. 2011.
1932-6203
10.1371/journal.pone.0026575
url https://www.arca.fiocruz.br/handle/icict/15040
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15040/1/license.txt
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