Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36580 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. |
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Resende, Samira DinizMagalhães, Fernanda do CarmoOliveira, Jailza Lima RodriguesCastro, Vanessa Normandia deSouza, Carolina Senra Alves deOliveira, Edward Jose deCarneiro, MariângelaGeiger, Stefan MichaelCorrêa, Deborah Aparecida Negrão2019-10-18T17:37:17Z2019-10-18T17:37:17Z2019RESENDE, Samira Diniz et al. Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum. Frontiers in Immunology, v. 9, p. 1-14, 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3658010.3389/fimmu.2018.03158engFrontiers Research FoundationModulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Seruminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Helminth infections and allergies are characterized by a predominant type-2 immune response. In schistosomiasis, the Th-2 response is usually accompanied by induction of immunoregulatory mechanisms that contribute to worm survival and less severe schistosomiasis. Although helminth-induced immunomodulatory mechanisms seem to affect atopy, epidemiological studies on the relationship between helminths and allergy have been inconsistent, and data suggest that the modulatory effects may be influenced by helminth species, chronicity of infection, and parasite burden. Here we performed a cross-sectional study to investigate the effects of Schistosoma mansoni parasite burden and immune response on allergic reactivity of individuals living in a schistosomiasis endemic area in Brazil. Fecal samples from the participants were collected for extensive parasitological examinations by spontaneous sedimentation, Kato-Katz, Helmintex and Saline Gradient tests and molecular detection of S. mansoni by qPCR. Additionally, the concentrations of cytokines and chemokines, total IgE and IgE-reactivity to common house dust allergens were quantified from serum samples. IgE reactivity to dust allergens was detected in 47 individuals (23.8%), and 140 individuals (54.4%) were diagnosed with S. mansoni infection. Most of the infected population (108 individuals) presented very low parasite burden (≤12 eggs/g of feces). The frequency and intensity (p ≤ 0.03) of allergic reactivity were lower in S. mansoni-infected compared with non-infected individuals. Multivariable logistic regression models adjusted by age revealed that allergic reactivity was positively associated with low IL-10 response (OR, 4.55, 95% CI, 0.56-7.36) and high concentration of the inflammatory mediators IL-33 (OR, 2.70, 95% CI, 1.02-7.15) or TNF-α (OR, 6.88, 95% CI, 0.32-143.39) in serum, and inversely associated with S. mansoni infection (OR, 0.38, 95% CI, 0.16-0.87). Most importantly, the logistic regression demonstrated that the modulatory effects of Schistosoma infection depend on parasite burden, with individuals infected with ≤12 eggs/g of feces showing allergic IgE-reactivity similar to non-infected individuals Altogether, our data show that immunomodulation of allergic reactivity depends on S. mansoni burden, low type-2 inflammatory response, and high level of IL-10.IL-10IL-33IgE-reactivitySchistosoma mansoniHousehold dust allergenHumansImmunoregulationLow parasite burdeninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/36580/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALModulation of Allergic Reactivity .pdfModulation of Allergic Reactivity 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| dc.title.pt_BR.fl_str_mv |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| title |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| spellingShingle |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum Resende, Samira Diniz IL-10 IL-33 IgE-reactivity Schistosoma mansoni Household dust allergen Humans Immunoregulation Low parasite burden |
| title_short |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| title_full |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| title_fullStr |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| title_full_unstemmed |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| title_sort |
Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum |
| author |
Resende, Samira Diniz |
| author_facet |
Resende, Samira Diniz Magalhães, Fernanda do Carmo Oliveira, Jailza Lima Rodrigues Castro, Vanessa Normandia de Souza, Carolina Senra Alves de Oliveira, Edward Jose de Carneiro, Mariângela Geiger, Stefan Michael Corrêa, Deborah Aparecida Negrão |
| author_role |
author |
| author2 |
Magalhães, Fernanda do Carmo Oliveira, Jailza Lima Rodrigues Castro, Vanessa Normandia de Souza, Carolina Senra Alves de Oliveira, Edward Jose de Carneiro, Mariângela Geiger, Stefan Michael Corrêa, Deborah Aparecida Negrão |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Resende, Samira Diniz Magalhães, Fernanda do Carmo Oliveira, Jailza Lima Rodrigues Castro, Vanessa Normandia de Souza, Carolina Senra Alves de Oliveira, Edward Jose de Carneiro, Mariângela Geiger, Stefan Michael Corrêa, Deborah Aparecida Negrão |
| dc.subject.en.pt_BR.fl_str_mv |
IL-10 IL-33 IgE-reactivity Schistosoma mansoni Household dust allergen Humans Immunoregulation Low parasite burden |
| topic |
IL-10 IL-33 IgE-reactivity Schistosoma mansoni Household dust allergen Humans Immunoregulation Low parasite burden |
| description |
Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. |
| publishDate |
2019 |
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2019-10-18T17:37:17Z |
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2019-10-18T17:37:17Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
RESENDE, Samira Diniz et al. Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum. Frontiers in Immunology, v. 9, p. 1-14, 2019. |
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https://www.arca.fiocruz.br/handle/icict/36580 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1664-3224 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.3389/fimmu.2018.03158 |
| identifier_str_mv |
RESENDE, Samira Diniz et al. Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma mansoni Parasite Burden, Low Levels of IL-33 or TNF-α and High Levels of IL-10 in Serum. Frontiers in Immunology, v. 9, p. 1-14, 2019. 1664-3224 10.3389/fimmu.2018.03158 |
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https://www.arca.fiocruz.br/handle/icict/36580 |
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eng |
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Frontiers Research Foundation |
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Frontiers Research Foundation |
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