Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report

Detalhes bibliográficos
Autor(a) principal: Brito, Carlos A. A.
Data de Publicação: 2018
Outros Autores: Henriques-Souza, Adélia, Soares, Cynthia R. P., Castanha, Priscila M. S., Machado, Laís C., Pereira, Mylena R., Sobral, Mariana C. M., Lucena-Araujo, Antonio R., Wallau, Gabriel da Luz, Franca, Rafael F. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36968
Resumo: Universidade Federal de Pernambuco. Departamento de Clínica Médica. Recife, PE, Brasil.
id CRUZ_aca3100a4f86bf0183ab481e4eace658
oai_identifier_str oai:www.arca.fiocruz.br:icict/36968
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Brito, Carlos A. A.Henriques-Souza, AdéliaSoares, Cynthia R. P.Castanha, Priscila M. S.Machado, Laís C.Pereira, Mylena R.Sobral, Mariana C. M.Lucena-Araujo, Antonio R.Wallau, Gabriel da LuzFranca, Rafael F. O.2019-11-11T12:26:09Z2019-11-11T12:26:09Z2018BRITO, Carlos A. A. et al. Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report. BMC infectious diseases, v. 18, n. 1, p. 1-9, 2018.1471-2334https://www.arca.fiocruz.br/handle/icict/3696810.1186/s12879-018-3313-41471-2334engPersistent detection of Zika virus RNA from an infant with severe microcephaly - a case reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Departamento de Clínica Médica. Recife, PE, Brasil.Hospital da Restauração. Departamento de Pediatria. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Biofísica. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Background: Zika virus (ZIKV) is a recently emerged arbovirus, which infection during pregnancy is associated with a series of congenital malformations, collectively denominated Congenital Zika Syndrome (CZS). Following infection, ZIKV RNA has a median duration period of 10 days in plasma and up to 6 months in semen in immunocompetent adult individuals. Moreover, ZIKV is able to replicate and persist in fetal brains and placentas, consequently, infection is associated with pregnancy loss, albeit the pathogenic mechanisms are still unknown. Case presentation: Here we report a CZS case of an infant born during the ZIKV outbreak in northeast Brazil, the child presented recurrent episodes of seizures with prolonged presence of ZIKV RNA on the central nervous system (CNS) and blood. ZIKV RNA was identified and partially sequenced from a sample of cerebrospinal fluid (CSF) obtained from the infant with 6 months of life, and later from another sample after the infant completed 17 months of life. Commonly congenital infections were discarded based on STORCH (syphilis, toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus) negative laboratory results. Presence of specific ZIKV antibodies on both mother and children confirmed the association of severe microcephaly and ZIKV infection, diagnosed after birth. Conclusions: Altogether, our data raise the possibility that CZS cases may result in prolonged viral presence, these findings could be useful for therapy and diagnostic recommendations.MicrocephalyNeurological diseaseVirus persistenceZika virusAdultoBrasilEpilepsia / etiologiaEpilepsia / patologiaEpilepsia / virologiaFemininoHumanosLactenteRecém-NascidoMicrocefalia / PatologiaMicrocefalia / virologiaGravidezComplicações Infecciosas na Gravidez / virologiaRNA Viral / isolamento & purificaçãoÍndice de Gravidade de DoençaZika virus / genéticaZika virus / isolamento & purificaçãoInfecção por Zika virus / complicaçõesInfecção por Zika viru / congênitoInfecção por Zika virus / diagnósticoInfecção por Zika virus / patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/36968/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALPersistent detection of Zika virus RNA from an infant with severe microcephaly – a case report.pdfPersistent detection of Zika virus RNA from an infant with severe microcephaly – a case report.pdfapplication/pdf3268288https://www.arca.fiocruz.br/bitstream/icict/36968/2/Persistent%20detection%20of%20Zika%20virus%20RNA%20from%20an%20infant%20with%20severe%20microcephaly%20%e2%80%93%20a%20case%20report.pdf0b3d03062d586c6aa1c5d0100aded8e6MD52TEXTPersistent detection of Zika virus RNA from an infant with severe microcephaly – a case report.pdf.txtPersistent detection of Zika virus RNA from an infant with severe microcephaly – a case report.pdf.txtExtracted texttext/plain33320https://www.arca.fiocruz.br/bitstream/icict/36968/3/Persistent%20detection%20of%20Zika%20virus%20RNA%20from%20an%20infant%20with%20severe%20microcephaly%20%e2%80%93%20a%20case%20report.pdf.txt04ce5210282d50fa3b896414866f6835MD53icict/369682021-05-10 16:16:16.195oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-05-10T19:16:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
title Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
spellingShingle Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
Brito, Carlos A. A.
Microcephaly
Neurological disease
Virus persistence
Zika virus
Adulto
Brasil
Epilepsia / etiologia
Epilepsia / patologia
Epilepsia / virologia
Feminino
Humanos
Lactente
Recém-Nascido
Microcefalia / Patologia
Microcefalia / virologia
Gravidez
Complicações Infecciosas na Gravidez / virologia
RNA Viral / isolamento & purificação
Índice de Gravidade de Doença
Zika virus / genética
Zika virus / isolamento & purificação
Infecção por Zika virus / complicações
Infecção por Zika viru / congênito
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / patologia
title_short Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
title_full Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
title_fullStr Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
title_full_unstemmed Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
title_sort Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report
author Brito, Carlos A. A.
author_facet Brito, Carlos A. A.
Henriques-Souza, Adélia
Soares, Cynthia R. P.
Castanha, Priscila M. S.
Machado, Laís C.
Pereira, Mylena R.
Sobral, Mariana C. M.
Lucena-Araujo, Antonio R.
Wallau, Gabriel da Luz
Franca, Rafael F. O.
author_role author
author2 Henriques-Souza, Adélia
Soares, Cynthia R. P.
Castanha, Priscila M. S.
Machado, Laís C.
Pereira, Mylena R.
Sobral, Mariana C. M.
Lucena-Araujo, Antonio R.
Wallau, Gabriel da Luz
Franca, Rafael F. O.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brito, Carlos A. A.
Henriques-Souza, Adélia
Soares, Cynthia R. P.
Castanha, Priscila M. S.
Machado, Laís C.
Pereira, Mylena R.
Sobral, Mariana C. M.
Lucena-Araujo, Antonio R.
Wallau, Gabriel da Luz
Franca, Rafael F. O.
dc.subject.en.pt_BR.fl_str_mv Microcephaly
Neurological disease
Virus persistence
Zika virus
topic Microcephaly
Neurological disease
Virus persistence
Zika virus
Adulto
Brasil
Epilepsia / etiologia
Epilepsia / patologia
Epilepsia / virologia
Feminino
Humanos
Lactente
Recém-Nascido
Microcefalia / Patologia
Microcefalia / virologia
Gravidez
Complicações Infecciosas na Gravidez / virologia
RNA Viral / isolamento & purificação
Índice de Gravidade de Doença
Zika virus / genética
Zika virus / isolamento & purificação
Infecção por Zika virus / complicações
Infecção por Zika viru / congênito
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / patologia
dc.subject.decs.pt_BR.fl_str_mv Adulto
Brasil
Epilepsia / etiologia
Epilepsia / patologia
Epilepsia / virologia
Feminino
Humanos
Lactente
Recém-Nascido
Microcefalia / Patologia
Microcefalia / virologia
Gravidez
Complicações Infecciosas na Gravidez / virologia
RNA Viral / isolamento & purificação
Índice de Gravidade de Doença
Zika virus / genética
Zika virus / isolamento & purificação
Infecção por Zika virus / complicações
Infecção por Zika viru / congênito
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / patologia
description Universidade Federal de Pernambuco. Departamento de Clínica Médica. Recife, PE, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-11-11T12:26:09Z
dc.date.available.fl_str_mv 2019-11-11T12:26:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRITO, Carlos A. A. et al. Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report. BMC infectious diseases, v. 18, n. 1, p. 1-9, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36968
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-018-3313-4
dc.identifier.eissn.none.fl_str_mv 1471-2334
identifier_str_mv BRITO, Carlos A. A. et al. Persistent detection of Zika virus RNA from an infant with severe microcephaly - a case report. BMC infectious diseases, v. 18, n. 1, p. 1-9, 2018.
1471-2334
10.1186/s12879-018-3313-4
url https://www.arca.fiocruz.br/handle/icict/36968
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36968/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36968/2/Persistent%20detection%20of%20Zika%20virus%20RNA%20from%20an%20infant%20with%20severe%20microcephaly%20%e2%80%93%20a%20case%20report.pdf
https://www.arca.fiocruz.br/bitstream/icict/36968/3/Persistent%20detection%20of%20Zika%20virus%20RNA%20from%20an%20infant%20with%20severe%20microcephaly%20%e2%80%93%20a%20case%20report.pdf.txt
bitstream.checksum.fl_str_mv 4194663c61da82c21746deb8d6361188
0b3d03062d586c6aa1c5d0100aded8e6
04ce5210282d50fa3b896414866f6835
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009292290162688

Registros relacionados