Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study

Detalhes bibliográficos
Autor(a) principal: Reis, Érica G.
Data de Publicação: 2016
Outros Autores: Schubach, Tânia M. P., Pereira, Sandro A., Silva, Jéssica N., Carvalho, Beatriz W., Quintana, Marcel S. B., Gremião, Isabella D. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32488
Resumo: 2020-04-15
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spelling Reis, Érica G.Schubach, Tânia M. P.Pereira, Sandro A.Silva, Jéssica N.Carvalho, Beatriz W.Quintana, Marcel S. B.Gremião, Isabella D. F.2019-04-15T14:18:21Z2019-04-15T14:18:21Z2016REIS, Érica G. et al. Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. Medical Mycology, v. 54, p. 684-690, 2016.1369-3786https://www.arca.fiocruz.br/handle/icict/3248810.1093/mmy/myw0271460-2709engOxford University PressAssociation of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-15Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil / Federal University of Rio Grande do Sul. Faculty of Veterinary Science. Department of Mycology. Porto Alegre, RS, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Feline sporotrichosis is an endemic disease in Rio de Janeiro, Brazil, where zoonotic transmission of Sporothrix spp. has been reported since 1998. Itraconazole (ITZ) remains the first choice for treating this disease in cats. However, there have been reports of therapeutic failure and a long-term endeavor. Potassium iodide (KI), considered in the past as a drug with variable effectiveness in cats with sporotrichosis, arises as an important option in the treatment of cats from the endemic area of Rio de Janeiro. In order to evaluate the effectiveness of the association of ITZ and KI in naive cats with sporotrichosis, a prospective cohort study was conducted on 30 cats receiving ITZ 100 mg/day and KI 2.5 mg-20 mg/kg/day. Clinical and laboratory adverse effects were assessed once a month according to the standard care protocol. The cure rate was 96.15% within a median of 14 weeks of treatment. Adverse effects were observed in 50% of cats and were managed with a temporary drug suspension and/or a hepatoprotective therapy. The association of ITZ and KI emerges as an effective option for the treatment of feline sporotrichosis.SporothrixCatsTherapyPotassium iodideItraconazoleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32488/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Reis_Érica_etal_INI_2016.pdfve_Reis_Érica_etal_INI_2016.pdfapplication/pdf1029901https://www.arca.fiocruz.br/bitstream/icict/32488/2/ve_Reis_%c3%89rica_etal_INI_2016.pdfd66529ba7488725bbe16f4bcea41613cMD52TEXTve_Reis_Érica_etal_INI_2016.pdf.txtve_Reis_Érica_etal_INI_2016.pdf.txtExtracted texttext/plain26645https://www.arca.fiocruz.br/bitstream/icict/32488/3/ve_Reis_%c3%89rica_etal_INI_2016.pdf.txtba8d42d9d7eededb0eb0e4e69a280e06MD53icict/324882021-03-24 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dc.title.pt_BR.fl_str_mv Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
title Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
spellingShingle Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
Reis, Érica G.
Sporothrix
Cats
Therapy
Potassium iodide
Itraconazole
title_short Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
title_full Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
title_fullStr Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
title_full_unstemmed Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
title_sort Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study
author Reis, Érica G.
author_facet Reis, Érica G.
Schubach, Tânia M. P.
Pereira, Sandro A.
Silva, Jéssica N.
Carvalho, Beatriz W.
Quintana, Marcel S. B.
Gremião, Isabella D. F.
author_role author
author2 Schubach, Tânia M. P.
Pereira, Sandro A.
Silva, Jéssica N.
Carvalho, Beatriz W.
Quintana, Marcel S. B.
Gremião, Isabella D. F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Érica G.
Schubach, Tânia M. P.
Pereira, Sandro A.
Silva, Jéssica N.
Carvalho, Beatriz W.
Quintana, Marcel S. B.
Gremião, Isabella D. F.
dc.subject.en.pt_BR.fl_str_mv Sporothrix
Cats
Therapy
Potassium iodide
Itraconazole
topic Sporothrix
Cats
Therapy
Potassium iodide
Itraconazole
description 2020-04-15
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-15T14:18:21Z
dc.date.available.fl_str_mv 2019-04-15T14:18:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Érica G. et al. Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. Medical Mycology, v. 54, p. 684-690, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32488
dc.identifier.issn.pt_BR.fl_str_mv 1369-3786
dc.identifier.doi.none.fl_str_mv 10.1093/mmy/myw027
dc.identifier.eissn.none.fl_str_mv 1460-2709
identifier_str_mv REIS, Érica G. et al. Association of itraconazole and potassium iodide in the treatment of feline sporotrichosis: a prospective study. Medical Mycology, v. 54, p. 684-690, 2016.
1369-3786
10.1093/mmy/myw027
1460-2709
url https://www.arca.fiocruz.br/handle/icict/32488
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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