Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10467 |
Resumo: | Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. |
| id |
CRUZ_dd7914b56e794b936916bea736308262 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/10467 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Jarduli, Luciana RibeiroAlves, Hugo VicentinSantana, Fabiana Covolo de SouzaMarcos, Elaine Valim CamarinhaPereira, Ana CarlaBaptista, Ida Maria Foschiani DiasFava, Vinicius MedeirosMira, Marcelo TávoraMoraes, Milton OzórioVirmond, Marcos da Cunha LopesVisentainer, Jeane Eliete Laguila2015-05-22T18:42:42Z2015-05-22T18:42:42Z2014JARDULI, Luciana Ribeiro et al. Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infectious Diseases, v.14:438, 8p, 2014.1471-2334https://www.arca.fiocruz.br/handle/icict/1046710.1186/1471-2334-14-438engBiomed CentralHanseníaseLeprosyKIR genesNK cellsLepraHanseníaseInfluence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.Background: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. Methods: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise multivariate analysis. Results: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form. Conclusions: This study showed that activating and inhibitory KIR genes may influence the development of leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby demonstrating the role of NK cells in the immunopathology of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10467/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmilton_moraes2eta_IOC_2014.pdfapplication/pdf315752https://www.arca.fiocruz.br/bitstream/icict/10467/2/milton_moraes2eta_IOC_2014.pdfec1415a63840f2c2ca8887ca39d68f15MD52TEXTmilton_moraes2eta_IOC_2014.pdf.txtmilton_moraes2eta_IOC_2014.pdf.txtExtracted texttext/plain38727https://www.arca.fiocruz.br/bitstream/icict/10467/3/milton_moraes2eta_IOC_2014.pdf.txt015f550ca069a49592653f699a91c4f5MD53icict/104672022-06-24 12:18:59.417oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| title |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| spellingShingle |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil Jarduli, Luciana Ribeiro Hanseníase Leprosy KIR genes NK cells Lepra Hanseníase |
| title_short |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| title_full |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| title_fullStr |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| title_full_unstemmed |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| title_sort |
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
| author |
Jarduli, Luciana Ribeiro |
| author_facet |
Jarduli, Luciana Ribeiro Alves, Hugo Vicentin Santana, Fabiana Covolo de Souza Marcos, Elaine Valim Camarinha Pereira, Ana Carla Baptista, Ida Maria Foschiani Dias Fava, Vinicius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila |
| author_role |
author |
| author2 |
Alves, Hugo Vicentin Santana, Fabiana Covolo de Souza Marcos, Elaine Valim Camarinha Pereira, Ana Carla Baptista, Ida Maria Foschiani Dias Fava, Vinicius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jarduli, Luciana Ribeiro Alves, Hugo Vicentin Santana, Fabiana Covolo de Souza Marcos, Elaine Valim Camarinha Pereira, Ana Carla Baptista, Ida Maria Foschiani Dias Fava, Vinicius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase |
| topic |
Hanseníase Leprosy KIR genes NK cells Lepra Hanseníase |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy KIR genes NK cells |
| dc.subject.es.pt_BR.fl_str_mv |
Lepra |
| dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase |
| description |
Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014 |
| dc.date.accessioned.fl_str_mv |
2015-05-22T18:42:42Z |
| dc.date.available.fl_str_mv |
2015-05-22T18:42:42Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
JARDULI, Luciana Ribeiro et al. Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infectious Diseases, v.14:438, 8p, 2014. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10467 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1471-2334 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/1471-2334-14-438 |
| identifier_str_mv |
JARDULI, Luciana Ribeiro et al. Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infectious Diseases, v.14:438, 8p, 2014. 1471-2334 10.1186/1471-2334-14-438 |
| url |
https://www.arca.fiocruz.br/handle/icict/10467 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Biomed Central |
| publisher.none.fl_str_mv |
Biomed Central |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/10467/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/10467/2/milton_moraes2eta_IOC_2014.pdf https://www.arca.fiocruz.br/bitstream/icict/10467/3/milton_moraes2eta_IOC_2014.pdf.txt |
| bitstream.checksum.fl_str_mv |
7d48279ffeed55da8dfe2f8e81f3b81f ec1415a63840f2c2ca8887ca39d68f15 015f550ca069a49592653f699a91c4f5 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009168322265088 |