Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry

Detalhes bibliográficos
Autor(a) principal: Marcolino, Milena Soriano
Data de Publicação: 2021
Outros Autores: Ziegelmann, Patricia K., Souza-Silva, Maira V.R., Nascimento, Israel J. Borges do, Oliveira, Luana M., Monteiro, Luanna S., Sales, Thaís L.S., Ruschel, Karen B., Martins, Karina P. M. P., Etges, Ana Paula B. S., Molina, Israel, Polanczyk, Carisi A., Brazilian COVID-19
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45874
Resumo: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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spelling Marcolino, Milena SorianoZiegelmann, Patricia K.Souza-Silva, Maira V.R.Nascimento, Israel J. Borges doOliveira, Luana M.Monteiro, Luanna S.Sales, Thaís L.S.Ruschel, Karen B.Martins, Karina P. M. P.Etges, Ana Paula B. S.Molina, IsraelPolanczyk, Carisi A.Brazilian COVID-192021-01-29T16:46:20Z2021-01-29T16:46:20Z2021MARCOLINO, Milena Soriano et al. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry. International Journal of Infectious Diseases, p. 1-51, 2021.1201-9712https://www.arca.fiocruz.br/handle/icict/4587410.1016/j.ijid.2021.01.019Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil.Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Center for Research and Graduate Studies in Business Administration, Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil.Universidade Federal de São João del-Rey. Divinópolis, MG, Brazil.Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.Universidade Federal de Minas Gerais. Medical School and University Hospital. Belo Horizonte, MG, Brazil.Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, BrazilVall d’Hebron University Hospital, PROSICS Barcelona. Barcelona, Spain / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal do Rio Grande do Sul. Institute for Health Technology Assessment. Porto Alegre, RS, Brazil.Objectives: To describe clinical characteristics, laboratory and imaging findings, as well as in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. Methods: Cohort study of laboratory-confirmed COVID-19 patients hospitalized from March to September 2020 at 25 hospitals. Study data were collected from medical records using Research Electronic Data Capture (REDCap) tools. Multivariate Poisson regression model was used to assess risk factors for in-hospital mortality. Results: Of 2054 patients (52.6% male, median age 58 years old), in-hospital mortality was 22.0%, and 47.6% among those treated in the ICU. Hypertension (52.9%), diabetes (29.2%) and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation and 12.1% kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1% and acute heart failure in 3.6%. Age ≥65 years-old, chronic kidney disease, hypertension, C-reactive protein ≥100 mg/dL, platelet count <100 × 109/L, oxygen saturation <90%, supplementary oxygen requirement and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. Conclusions: This study provides characteristics and in-hospital outcomes of consecutively hospitalized patients with confirmed COVID-19 in Brazil. Easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients.engElsevierCOVID-19SARS-CoV-2HospitalizaçõesPandemiaBrazilMortalityDisease progressionCOVID-19SARS-CoV-2HospitalizationsPandemicMortalidadeDoenças progressivasClinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
title Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
spellingShingle Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
Marcolino, Milena Soriano
COVID-19
SARS-CoV-2
Hospitalizações
Pandemia
Brazil
Mortality
Disease progression
COVID-19
SARS-CoV-2
Hospitalizations
Pandemic
Mortalidade
Doenças progressivas
title_short Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
title_full Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
title_fullStr Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
title_full_unstemmed Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
title_sort Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry
author Marcolino, Milena Soriano
author_facet Marcolino, Milena Soriano
Ziegelmann, Patricia K.
Souza-Silva, Maira V.R.
Nascimento, Israel J. Borges do
Oliveira, Luana M.
Monteiro, Luanna S.
Sales, Thaís L.S.
Ruschel, Karen B.
Martins, Karina P. M. P.
Etges, Ana Paula B. S.
Molina, Israel
Polanczyk, Carisi A.
Brazilian COVID-19
author_role author
author2 Ziegelmann, Patricia K.
Souza-Silva, Maira V.R.
Nascimento, Israel J. Borges do
Oliveira, Luana M.
Monteiro, Luanna S.
Sales, Thaís L.S.
Ruschel, Karen B.
Martins, Karina P. M. P.
Etges, Ana Paula B. S.
Molina, Israel
Polanczyk, Carisi A.
Brazilian COVID-19
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marcolino, Milena Soriano
Ziegelmann, Patricia K.
Souza-Silva, Maira V.R.
Nascimento, Israel J. Borges do
Oliveira, Luana M.
Monteiro, Luanna S.
Sales, Thaís L.S.
Ruschel, Karen B.
Martins, Karina P. M. P.
Etges, Ana Paula B. S.
Molina, Israel
Polanczyk, Carisi A.
Brazilian COVID-19
dc.subject.other.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Hospitalizações
Pandemia
Brazil
Mortality
Disease progression
topic COVID-19
SARS-CoV-2
Hospitalizações
Pandemia
Brazil
Mortality
Disease progression
COVID-19
SARS-CoV-2
Hospitalizations
Pandemic
Mortalidade
Doenças progressivas
dc.subject.en.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Hospitalizations
Pandemic
Mortalidade
Doenças progressivas
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-01-29T16:46:20Z
dc.date.available.fl_str_mv 2021-01-29T16:46:20Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MARCOLINO, Milena Soriano et al. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry. International Journal of Infectious Diseases, p. 1-51, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45874
dc.identifier.issn.pt_BR.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2021.01.019
identifier_str_mv MARCOLINO, Milena Soriano et al. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: results from the Brazilian COVID-19 Registry. International Journal of Infectious Diseases, p. 1-51, 2021.
1201-9712
10.1016/j.ijid.2021.01.019
url https://www.arca.fiocruz.br/handle/icict/45874
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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