ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores

Detalhes bibliográficos
Autor(a) principal: Marcolino, Milena S.
Data de Publicação: 2021
Outros Autores: Pires, Magda C., Ramos, Lucas Emanuel F., Silva, Rafael T., Oliveira, Luana M., Carvalho, Rafael L.R., Mourato, Rodolfo Lucas S., Sánchez-Montalvá, Adrián, Raventós, Berta, Anschau, Fernando, Chatkin, José Miguel, Nogueira, Matheus C.A., Guimarães-Júnior, Milton H., Vietta, Giovanna G., Duani, Helena, Ponce, Daniela [UNESP], Ziegelmann, Patricia K., Castro, Luís C., Ruschel, Karen B., Cimini, Christiane C.R., Francisco, Saionara C., Floriani, Maiara A., Nascimento, Guilherme F., Farace, Bárbara L., Monteiro, Luanna S., Souza-Silva, Maira V.R., Sales, Thais L.S., Martins, Karina Paula M.P., Borges do Nascimento, Israel J., Fereguetti, Tatiani O., Ferrara, Daniel T.M.O., Botoni, Fernando A., Etges, Ana Paula B.S., Schwarzbold, Alexandre V., Maurílio, Amanda O., Scotton, Ana Luiza B.A., Weber, André P., Costa, André S.M., Glaeser, Andressa B., Madureira, Angélica Aparecida C., Bhering, Angelinda R., de Castro, Bruno Mateus, da Silva, Carla Thais C.A., Ramos, Carolina M., Gomes, Caroline D., de Carvalho, Cíntia A., Silveira, Daniel V., Cezar, Edilson, Pereira, Elayne C., Kroger, Emanuele Marianne S., Vallt, Felipe B., Lucas, Fernanda B., Aranha, Fernando G., Bartolazzi, Frederico, Crestani, Gabriela P., Bastos, Gisele A.N., Madeira, Glícia Cristina de C., Noal, Helena Carolina, Vianna, Heloisa R., Guimarães, Henrique C., Gomes, Isabela M., Molina, Israel, Batista, Joanna d'Arc L., de Alvarenga, Joice C., Guimarães, Júlia D.S.S., de Morais, Júlia D.P., Rugolo, Juliana M. [UNESP], Pontes, Karen Cristina J.R., dos Santos, Kauane Aline M., de Oliveira, Leonardo S., Pinheiro, Lílian S., Pacheco, Liliane S., Sousa, Lucas de D., Couto, Luciana S.F., Kopittke, Luciane, de Moura, Luis Cesar S., Santos, Luisa Elem A., Cabral, Máderson A.S., Souza, Maíra D., Tofani, Marcela G.T., Carneiro, Marcelo, Ferreira, Maria Angélica P., Bicalho, Maria Aparecida C., Lima, Maria Clara P.B., Godoy, Mariana F., Cardoso, Marilia M.A. [UNESP], Figueiredo, Meire P., Sampaio, Natália C.S., Rangel, Natália L., Crespo, Natália T., de Oliveira, Neimy R., Assaf, Pedro L., Martelli, Petrônio José de L., Almeida, Rafaela S.C., Martins, Raphael C., Lutkmeier, Raquel, Valacio, Reginaldo Aparecido, Finger, Renan G., Cardoso, Ricardo B., Pozza, Roberta, Campos, Roberta X., Menezes, Rochele M., de Abreu, Roger M., Silva, Rufino de F., Guimarães, Silvana M.M., Araújo, Silvia F., Pereira, Susany Anastácia, Oliveira, Talita F., Kurtz, Tatiana, de Oliveira, Thainara C., Araújo, Thaíza Simônia M.A., Diniz, Thulio Henrique O., dos Santos, Veridiana B., Gomes, Virginia Mara R., do Vale, Vitor Augusto L., Ramires, Yuri C., Boersma, Eric, Polanczyk, Carisi A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.ijid.2021.07.049
http://hdl.handle.net/11449/229327
Resumo: Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March–July, 2020. The model was validated in the 1054 patients admitted during August–September, as well as in an external cohort of 474 Spanish patients. Results: Median (25–75th percentile) age of the model-derivation cohort was 60 (48–72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829–0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833–0.885]) and Spanish (0.894 [95% CI 0.870–0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19.
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spelling ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scoresCOVID-19HospitalizationsMortalityPrognosisRisk factorsSARS-CoV-2ScoreObjectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March–July, 2020. The model was validated in the 1054 patients admitted during August–September, as well as in an external cohort of 474 Spanish patients. Results: Median (25–75th percentile) age of the model-derivation cohort was 60 (48–72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829–0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833–0.885]) and Spanish (0.894 [95% CI 0.870–0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Internal Medicine Medical School Universidade Federal de Minas GeraisTelehealth Center University Hospital Universidade Federal de Minas GeraisInstitute for Health Technology Assessment IATS/ CNPq)., Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507Department of Statistics Universidade Federal de Minas GeraisCenter for Research and Graduate Studies in Business Administration Universidade Federal de Minas GeraisUniversidade Federal de São João del-ReiInfectious Diseases Department Vall d'Hebron University Hospita Universitat Autònoma de BarcelonaHospital Nossa Senhora da Conceição and Hospital Cristo Redentor Grupo Hospitalar ConceiçãoPontifícia Universidade Católica do Rio Grande do Sul RGS)Hospital São Lucas PUCRSRede Mater Dei de SaúdeHospital Márcio CunhaUniversidade do Sul de Santa Catarina UNISULDissertare Scientific AdviceSOS Cardio HospitalInternal Medicine Department University Hospital Universidade Federal de Minas GeraisFaculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita FilhoHospital das Clínicas da Faculdade de Medicina de BotucatuUniversidade Federal do Rio Grande do SulHospital Bruno BornResearch Center of Vale do Taquari.Hospital Mãe de DeusHospital Universitário de CanoasMucuri Medical School FAMMUC Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJMHospital Santa RosaliaHospital Metropolitano Doutor Célio de CastroHospital Moinhos de VentoHospital Unimed BHHospital Risoleta Tolentino NevesPost-graduation Center Medical School Universidade Federal de Minas GeraisHospital Metropolitano Odilon BehrensHospital Eduardo de MenezesUniversidade FUMECHospital Julia KubitschekHospital Universitário de Santa MariaDepartamento de Medicina Interna Universidade Federal de Santa MariaHospital São João de DeusHospital Regional Antônio DiasFaculdade Ciências Médicas de Minas GeraisHospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do SulFaculdade de Ciências Humanas de CurveloHospital João XXIII Av. Professor Alfredo BalenaHospital Santo AntônioHospital Universitário Ciências MédicasVall d'Hebron University Hospital PROSICS BarcelonaInstituto René Rachou-FIOCRUZ Minas.Universidade Federal da Fronteira SulHospital Regional do OestePontifícia Universidade Católica de Minas GeraisHospital TacchiniCentro Universitário de Patos de Minas. RPatos de MinasHospital SemperHospital Santa CruzUniversidade de Santa CruzFundação Hospitalar do Estado de Minas Gerais – FHEMIG.Universidade Federal de Ouro PretoHospital das Clínicas da Universidade Federal de PernambucoUniversidade Federal de Pernambuco Centro de Ciências MédicasCentro Universitário de Belo Horizonte UniBH)Erasmus MC University Medical Center Rotterdam Department of CardiologyFaculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita FilhoHospital das Clínicas da Faculdade de Medicina de BotucatuUniversidade Federal de Minas Gerais (UFMG)Institute for Health Technology Assessment IATS/ CNPq).Universidade Federal de São João del-ReiUniversitat Autònoma de BarcelonaGrupo Hospitalar ConceiçãoPontifícia Universidade Católica do Rio Grande do Sul RGS)Hospital São Lucas PUCRSRede Mater Dei de SaúdeHospital Márcio CunhaUniversidade do Sul de Santa Catarina UNISULDissertare Scientific AdviceSOS Cardio HospitalUniversidade Estadual Paulista (UNESP)Universidade Federal do Rio Grande do SulHospital Bruno BornResearch Center of Vale do Taquari.Hospital Mãe de DeusHospital Universitário de CanoasUniversidade Federal de Viçosa (UFV)Hospital Santa RosaliaHospital Metropolitano Doutor Célio de CastroHospital Moinhos de VentoHospital Unimed BHHospital Risoleta Tolentino NevesHospital Metropolitano Odilon BehrensHospital Eduardo de MenezesUniversidade FUMECHospital Julia KubitschekHospital Universitário de Santa MariaUniversidade Federal de Santa MariaHospital São João de DeusHospital Regional Antônio DiasFaculdade Ciências Médicas de Minas GeraisFaculdade de Ciências Humanas de CurveloAv. Professor Alfredo BalenaHospital Santo AntônioHospital Universitário Ciências MédicasPROSICS BarcelonaInstituto René Rachou-FIOCRUZ Minas.Universidade Federal da Fronteira SulHospital Regional do OestePontifícia Universidade Católica de Minas GeraisHospital TacchiniCentro Universitário de Patos de Minas. RPatos de MinasHospital SemperHospital Santa CruzUniversidade de Santa CruzFundação Hospitalar do Estado de Minas Gerais – FHEMIG.Universidade Federal de Ouro PretoUniversidade Federal de Pernambuco (UFPE)Centro Universitário de Belo Horizonte UniBH)University Medical Center RotterdamMarcolino, Milena S.Pires, Magda C.Ramos, Lucas Emanuel F.Silva, Rafael T.Oliveira, Luana M.Carvalho, Rafael L.R.Mourato, Rodolfo Lucas S.Sánchez-Montalvá, AdriánRaventós, BertaAnschau, FernandoChatkin, José MiguelNogueira, Matheus C.A.Guimarães-Júnior, Milton H.Vietta, Giovanna G.Duani, HelenaPonce, Daniela [UNESP]Ziegelmann, Patricia K.Castro, Luís C.Ruschel, Karen B.Cimini, Christiane C.R.Francisco, Saionara C.Floriani, Maiara A.Nascimento, Guilherme F.Farace, Bárbara L.Monteiro, Luanna S.Souza-Silva, Maira V.R.Sales, Thais L.S.Martins, Karina Paula M.P.Borges do Nascimento, Israel J.Fereguetti, Tatiani O.Ferrara, Daniel T.M.O.Botoni, Fernando A.Etges, Ana Paula B.S.Schwarzbold, Alexandre V.Maurílio, Amanda O.Scotton, Ana Luiza B.A.Weber, André P.Costa, André S.M.Glaeser, Andressa B.Madureira, Angélica Aparecida C.Bhering, Angelinda R.de Castro, Bruno Mateusda Silva, Carla Thais C.A.Ramos, Carolina M.Gomes, Caroline D.de Carvalho, Cíntia A.Silveira, Daniel V.Cezar, EdilsonPereira, Elayne C.Kroger, Emanuele Marianne S.Vallt, Felipe B.Lucas, Fernanda B.Aranha, Fernando G.Bartolazzi, FredericoCrestani, Gabriela P.Bastos, Gisele A.N.Madeira, Glícia Cristina de C.Noal, Helena CarolinaVianna, Heloisa R.Guimarães, Henrique C.Gomes, Isabela M.Molina, IsraelBatista, Joanna d'Arc L.de Alvarenga, Joice C.Guimarães, Júlia D.S.S.de Morais, Júlia D.P.Rugolo, Juliana M. [UNESP]Pontes, Karen Cristina J.R.dos Santos, Kauane Aline M.de Oliveira, Leonardo S.Pinheiro, Lílian S.Pacheco, Liliane S.Sousa, Lucas de D.Couto, Luciana S.F.Kopittke, Lucianede Moura, Luis Cesar S.Santos, Luisa Elem A.Cabral, Máderson A.S.Souza, Maíra D.Tofani, Marcela G.T.Carneiro, MarceloFerreira, Maria Angélica P.Bicalho, Maria Aparecida C.Lima, Maria Clara P.B.Godoy, Mariana F.Cardoso, Marilia M.A. [UNESP]Figueiredo, Meire P.Sampaio, Natália C.S.Rangel, Natália L.Crespo, Natália T.de Oliveira, Neimy R.Assaf, Pedro L.Martelli, Petrônio José de L.Almeida, Rafaela S.C.Martins, Raphael C.Lutkmeier, RaquelValacio, Reginaldo AparecidoFinger, Renan G.Cardoso, Ricardo B.Pozza, RobertaCampos, Roberta X.Menezes, Rochele M.de Abreu, Roger M.Silva, Rufino de F.Guimarães, Silvana M.M.Araújo, Silvia F.Pereira, Susany AnastáciaOliveira, Talita F.Kurtz, Tatianade Oliveira, Thainara C.Araújo, Thaíza Simônia M.A.Diniz, Thulio Henrique O.dos Santos, Veridiana B.Gomes, Virginia Mara R.do Vale, Vitor Augusto L.Ramires, Yuri C.Boersma, EricPolanczyk, Carisi A.2022-04-29T08:31:56Z2022-04-29T08:31:56Z2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article281-308http://dx.doi.org/10.1016/j.ijid.2021.07.049International Journal of Infectious Diseases, v. 110, p. 281-308.1878-35111201-9712http://hdl.handle.net/11449/22932710.1016/j.ijid.2021.07.0492-s2.0-85112538955Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccess2024-09-30T17:35:03Zoai:repositorio.unesp.br:11449/229327Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-30T17:35:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
title ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
spellingShingle ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
Marcolino, Milena S.
COVID-19
Hospitalizations
Mortality
Prognosis
Risk factors
SARS-CoV-2
Score
title_short ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
title_full ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
title_fullStr ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
title_full_unstemmed ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
title_sort ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
author Marcolino, Milena S.
author_facet Marcolino, Milena S.
Pires, Magda C.
Ramos, Lucas Emanuel F.
Silva, Rafael T.
Oliveira, Luana M.
Carvalho, Rafael L.R.
Mourato, Rodolfo Lucas S.
Sánchez-Montalvá, Adrián
Raventós, Berta
Anschau, Fernando
Chatkin, José Miguel
Nogueira, Matheus C.A.
Guimarães-Júnior, Milton H.
Vietta, Giovanna G.
Duani, Helena
Ponce, Daniela [UNESP]
Ziegelmann, Patricia K.
Castro, Luís C.
Ruschel, Karen B.
Cimini, Christiane C.R.
Francisco, Saionara C.
Floriani, Maiara A.
Nascimento, Guilherme F.
Farace, Bárbara L.
Monteiro, Luanna S.
Souza-Silva, Maira V.R.
Sales, Thais L.S.
Martins, Karina Paula M.P.
Borges do Nascimento, Israel J.
Fereguetti, Tatiani O.
Ferrara, Daniel T.M.O.
Botoni, Fernando A.
Etges, Ana Paula B.S.
Schwarzbold, Alexandre V.
Maurílio, Amanda O.
Scotton, Ana Luiza B.A.
Weber, André P.
Costa, André S.M.
Glaeser, Andressa B.
Madureira, Angélica Aparecida C.
Bhering, Angelinda R.
de Castro, Bruno Mateus
da Silva, Carla Thais C.A.
Ramos, Carolina M.
Gomes, Caroline D.
de Carvalho, Cíntia A.
Silveira, Daniel V.
Cezar, Edilson
Pereira, Elayne C.
Kroger, Emanuele Marianne S.
Vallt, Felipe B.
Lucas, Fernanda B.
Aranha, Fernando G.
Bartolazzi, Frederico
Crestani, Gabriela P.
Bastos, Gisele A.N.
Madeira, Glícia Cristina de C.
Noal, Helena Carolina
Vianna, Heloisa R.
Guimarães, Henrique C.
Gomes, Isabela M.
Molina, Israel
Batista, Joanna d'Arc L.
de Alvarenga, Joice C.
Guimarães, Júlia D.S.S.
de Morais, Júlia D.P.
Rugolo, Juliana M. [UNESP]
Pontes, Karen Cristina J.R.
dos Santos, Kauane Aline M.
de Oliveira, Leonardo S.
Pinheiro, Lílian S.
Pacheco, Liliane S.
Sousa, Lucas de D.
Couto, Luciana S.F.
Kopittke, Luciane
de Moura, Luis Cesar S.
Santos, Luisa Elem A.
Cabral, Máderson A.S.
Souza, Maíra D.
Tofani, Marcela G.T.
Carneiro, Marcelo
Ferreira, Maria Angélica P.
Bicalho, Maria Aparecida C.
Lima, Maria Clara P.B.
Godoy, Mariana F.
Cardoso, Marilia M.A. [UNESP]
Figueiredo, Meire P.
Sampaio, Natália C.S.
Rangel, Natália L.
Crespo, Natália T.
de Oliveira, Neimy R.
Assaf, Pedro L.
Martelli, Petrônio José de L.
Almeida, Rafaela S.C.
Martins, Raphael C.
Lutkmeier, Raquel
Valacio, Reginaldo Aparecido
Finger, Renan G.
Cardoso, Ricardo B.
Pozza, Roberta
Campos, Roberta X.
Menezes, Rochele M.
de Abreu, Roger M.
Silva, Rufino de F.
Guimarães, Silvana M.M.
Araújo, Silvia F.
Pereira, Susany Anastácia
Oliveira, Talita F.
Kurtz, Tatiana
de Oliveira, Thainara C.
Araújo, Thaíza Simônia M.A.
Diniz, Thulio Henrique O.
dos Santos, Veridiana B.
Gomes, Virginia Mara R.
do Vale, Vitor Augusto L.
Ramires, Yuri C.
Boersma, Eric
Polanczyk, Carisi A.
author_role author
author2 Pires, Magda C.
Ramos, Lucas Emanuel F.
Silva, Rafael T.
Oliveira, Luana M.
Carvalho, Rafael L.R.
Mourato, Rodolfo Lucas S.
Sánchez-Montalvá, Adrián
Raventós, Berta
Anschau, Fernando
Chatkin, José Miguel
Nogueira, Matheus C.A.
Guimarães-Júnior, Milton H.
Vietta, Giovanna G.
Duani, Helena
Ponce, Daniela [UNESP]
Ziegelmann, Patricia K.
Castro, Luís C.
Ruschel, Karen B.
Cimini, Christiane C.R.
Francisco, Saionara C.
Floriani, Maiara A.
Nascimento, Guilherme F.
Farace, Bárbara L.
Monteiro, Luanna S.
Souza-Silva, Maira V.R.
Sales, Thais L.S.
Martins, Karina Paula M.P.
Borges do Nascimento, Israel J.
Fereguetti, Tatiani O.
Ferrara, Daniel T.M.O.
Botoni, Fernando A.
Etges, Ana Paula B.S.
Schwarzbold, Alexandre V.
Maurílio, Amanda O.
Scotton, Ana Luiza B.A.
Weber, André P.
Costa, André S.M.
Glaeser, Andressa B.
Madureira, Angélica Aparecida C.
Bhering, Angelinda R.
de Castro, Bruno Mateus
da Silva, Carla Thais C.A.
Ramos, Carolina M.
Gomes, Caroline D.
de Carvalho, Cíntia A.
Silveira, Daniel V.
Cezar, Edilson
Pereira, Elayne C.
Kroger, Emanuele Marianne S.
Vallt, Felipe B.
Lucas, Fernanda B.
Aranha, Fernando G.
Bartolazzi, Frederico
Crestani, Gabriela P.
Bastos, Gisele A.N.
Madeira, Glícia Cristina de C.
Noal, Helena Carolina
Vianna, Heloisa R.
Guimarães, Henrique C.
Gomes, Isabela M.
Molina, Israel
Batista, Joanna d'Arc L.
de Alvarenga, Joice C.
Guimarães, Júlia D.S.S.
de Morais, Júlia D.P.
Rugolo, Juliana M. [UNESP]
Pontes, Karen Cristina J.R.
dos Santos, Kauane Aline M.
de Oliveira, Leonardo S.
Pinheiro, Lílian S.
Pacheco, Liliane S.
Sousa, Lucas de D.
Couto, Luciana S.F.
Kopittke, Luciane
de Moura, Luis Cesar S.
Santos, Luisa Elem A.
Cabral, Máderson A.S.
Souza, Maíra D.
Tofani, Marcela G.T.
Carneiro, Marcelo
Ferreira, Maria Angélica P.
Bicalho, Maria Aparecida C.
Lima, Maria Clara P.B.
Godoy, Mariana F.
Cardoso, Marilia M.A. [UNESP]
Figueiredo, Meire P.
Sampaio, Natália C.S.
Rangel, Natália L.
Crespo, Natália T.
de Oliveira, Neimy R.
Assaf, Pedro L.
Martelli, Petrônio José de L.
Almeida, Rafaela S.C.
Martins, Raphael C.
Lutkmeier, Raquel
Valacio, Reginaldo Aparecido
Finger, Renan G.
Cardoso, Ricardo B.
Pozza, Roberta
Campos, Roberta X.
Menezes, Rochele M.
de Abreu, Roger M.
Silva, Rufino de F.
Guimarães, Silvana M.M.
Araújo, Silvia F.
Pereira, Susany Anastácia
Oliveira, Talita F.
Kurtz, Tatiana
de Oliveira, Thainara C.
Araújo, Thaíza Simônia M.A.
Diniz, Thulio Henrique O.
dos Santos, Veridiana B.
Gomes, Virginia Mara R.
do Vale, Vitor Augusto L.
Ramires, Yuri C.
Boersma, Eric
Polanczyk, Carisi A.
author2_role author
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dc.contributor.none.fl_str_mv Universidade Federal de Minas Gerais (UFMG)
Institute for Health Technology Assessment IATS/ CNPq).
Universidade Federal de São João del-Rei
Universitat Autònoma de Barcelona
Grupo Hospitalar Conceição
Pontifícia Universidade Católica do Rio Grande do Sul RGS)
Hospital São Lucas PUCRS
Rede Mater Dei de Saúde
Hospital Márcio Cunha
Universidade do Sul de Santa Catarina UNISUL
Dissertare Scientific Advice
SOS Cardio Hospital
Universidade Estadual Paulista (UNESP)
Universidade Federal do Rio Grande do Sul
Hospital Bruno Born
Research Center of Vale do Taquari.
Hospital Mãe de Deus
Hospital Universitário de Canoas
Universidade Federal de Viçosa (UFV)
Hospital Santa Rosalia
Hospital Metropolitano Doutor Célio de Castro
Hospital Moinhos de Vento
Hospital Unimed BH
Hospital Risoleta Tolentino Neves
Hospital Metropolitano Odilon Behrens
Hospital Eduardo de Menezes
Universidade FUMEC
Hospital Julia Kubitschek
Hospital Universitário de Santa Maria
Universidade Federal de Santa Maria
Hospital São João de Deus
Hospital Regional Antônio Dias
Faculdade Ciências Médicas de Minas Gerais
Faculdade de Ciências Humanas de Curvelo
Av. Professor Alfredo Balena
Hospital Santo Antônio
Hospital Universitário Ciências Médicas
PROSICS Barcelona
Instituto René Rachou-FIOCRUZ Minas.
Universidade Federal da Fronteira Sul
Hospital Regional do Oeste
Pontifícia Universidade Católica de Minas Gerais
Hospital Tacchini
Centro Universitário de Patos de Minas. RPatos de Minas
Hospital Semper
Hospital Santa Cruz
Universidade de Santa Cruz
Fundação Hospitalar do Estado de Minas Gerais – FHEMIG.
Universidade Federal de Ouro Preto
Universidade Federal de Pernambuco (UFPE)
Centro Universitário de Belo Horizonte UniBH)
University Medical Center Rotterdam
dc.contributor.author.fl_str_mv Marcolino, Milena S.
Pires, Magda C.
Ramos, Lucas Emanuel F.
Silva, Rafael T.
Oliveira, Luana M.
Carvalho, Rafael L.R.
Mourato, Rodolfo Lucas S.
Sánchez-Montalvá, Adrián
Raventós, Berta
Anschau, Fernando
Chatkin, José Miguel
Nogueira, Matheus C.A.
Guimarães-Júnior, Milton H.
Vietta, Giovanna G.
Duani, Helena
Ponce, Daniela [UNESP]
Ziegelmann, Patricia K.
Castro, Luís C.
Ruschel, Karen B.
Cimini, Christiane C.R.
Francisco, Saionara C.
Floriani, Maiara A.
Nascimento, Guilherme F.
Farace, Bárbara L.
Monteiro, Luanna S.
Souza-Silva, Maira V.R.
Sales, Thais L.S.
Martins, Karina Paula M.P.
Borges do Nascimento, Israel J.
Fereguetti, Tatiani O.
Ferrara, Daniel T.M.O.
Botoni, Fernando A.
Etges, Ana Paula B.S.
Schwarzbold, Alexandre V.
Maurílio, Amanda O.
Scotton, Ana Luiza B.A.
Weber, André P.
Costa, André S.M.
Glaeser, Andressa B.
Madureira, Angélica Aparecida C.
Bhering, Angelinda R.
de Castro, Bruno Mateus
da Silva, Carla Thais C.A.
Ramos, Carolina M.
Gomes, Caroline D.
de Carvalho, Cíntia A.
Silveira, Daniel V.
Cezar, Edilson
Pereira, Elayne C.
Kroger, Emanuele Marianne S.
Vallt, Felipe B.
Lucas, Fernanda B.
Aranha, Fernando G.
Bartolazzi, Frederico
Crestani, Gabriela P.
Bastos, Gisele A.N.
Madeira, Glícia Cristina de C.
Noal, Helena Carolina
Vianna, Heloisa R.
Guimarães, Henrique C.
Gomes, Isabela M.
Molina, Israel
Batista, Joanna d'Arc L.
de Alvarenga, Joice C.
Guimarães, Júlia D.S.S.
de Morais, Júlia D.P.
Rugolo, Juliana M. [UNESP]
Pontes, Karen Cristina J.R.
dos Santos, Kauane Aline M.
de Oliveira, Leonardo S.
Pinheiro, Lílian S.
Pacheco, Liliane S.
Sousa, Lucas de D.
Couto, Luciana S.F.
Kopittke, Luciane
de Moura, Luis Cesar S.
Santos, Luisa Elem A.
Cabral, Máderson A.S.
Souza, Maíra D.
Tofani, Marcela G.T.
Carneiro, Marcelo
Ferreira, Maria Angélica P.
Bicalho, Maria Aparecida C.
Lima, Maria Clara P.B.
Godoy, Mariana F.
Cardoso, Marilia M.A. [UNESP]
Figueiredo, Meire P.
Sampaio, Natália C.S.
Rangel, Natália L.
Crespo, Natália T.
de Oliveira, Neimy R.
Assaf, Pedro L.
Martelli, Petrônio José de L.
Almeida, Rafaela S.C.
Martins, Raphael C.
Lutkmeier, Raquel
Valacio, Reginaldo Aparecido
Finger, Renan G.
Cardoso, Ricardo B.
Pozza, Roberta
Campos, Roberta X.
Menezes, Rochele M.
de Abreu, Roger M.
Silva, Rufino de F.
Guimarães, Silvana M.M.
Araújo, Silvia F.
Pereira, Susany Anastácia
Oliveira, Talita F.
Kurtz, Tatiana
de Oliveira, Thainara C.
Araújo, Thaíza Simônia M.A.
Diniz, Thulio Henrique O.
dos Santos, Veridiana B.
Gomes, Virginia Mara R.
do Vale, Vitor Augusto L.
Ramires, Yuri C.
Boersma, Eric
Polanczyk, Carisi A.
dc.subject.por.fl_str_mv COVID-19
Hospitalizations
Mortality
Prognosis
Risk factors
SARS-CoV-2
Score
topic COVID-19
Hospitalizations
Mortality
Prognosis
Risk factors
SARS-CoV-2
Score
description Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March–July, 2020. The model was validated in the 1054 patients admitted during August–September, as well as in an external cohort of 474 Spanish patients. Results: Median (25–75th percentile) age of the model-derivation cohort was 60 (48–72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829–0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833–0.885]) and Spanish (0.894 [95% CI 0.870–0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
2022-04-29T08:31:56Z
2022-04-29T08:31:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.ijid.2021.07.049
International Journal of Infectious Diseases, v. 110, p. 281-308.
1878-3511
1201-9712
http://hdl.handle.net/11449/229327
10.1016/j.ijid.2021.07.049
2-s2.0-85112538955
url http://dx.doi.org/10.1016/j.ijid.2021.07.049
http://hdl.handle.net/11449/229327
identifier_str_mv International Journal of Infectious Diseases, v. 110, p. 281-308.
1878-3511
1201-9712
10.1016/j.ijid.2021.07.049
2-s2.0-85112538955
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 281-308
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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