Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?

Detalhes bibliográficos
Autor(a) principal: Palma, Mariana L.
Data de Publicação: 2015
Outros Autores: Zamith-Miranda, Daniel, Martins, Flaviano S., Bozza, Fernando A., Nimrichter, Leonardo, Montero-Lomeli, Mônica, Marques, Ernesto T. A., Douradinha, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34762
Resumo: 2020-08-13
id CRUZ_b0356a08baafb681a81a62ebb34bb8ae
oai_identifier_str oai:www.arca.fiocruz.br:icict/34762
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Palma, Mariana L.Zamith-Miranda, DanielMartins, Flaviano S.Bozza, Fernando A.Nimrichter, LeonardoMontero-Lomeli, MônicaMarques, Ernesto T. A.Douradinha, Bruno2019-08-13T12:52:08Z2019-08-13T12:52:08Z2015PALMA, Mariana L. et al. Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement? Applied Microbiology and Biotechnology, v. 99, p. 6563-6570, 2015.0175-7598https://www.arca.fiocruz.br/handle/icict/3476210.1007/s00253-015-6776-x1432-0614engSpringerProbiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-13Universidade de São Paulo. Faculdade de Medicina. Faculdade de Medicina. São Paulo, SP, Brasil / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PA, USA.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo Goés. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo Goés. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, RJ, Brasil.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PA, USA / Fondazione RiMED. Palermo, Italy.The probiotic yeast Saccharomyces cerevisiae var boulardii is widely used as a low cost and efficient adjuvant against gastrointestinal tract disorders such as inflammatory bowel disease and treatment of several types of diarrhea, both in humans and animals. S. boulardii exerts its protective mechanisms by binding and neutralizing enteric pathogens or their toxins, by reducing inflammation and by inducing the secretion of sIgA. Although several S. cerevisiae strains have proven probiotic potential in both humans and animals, only S. boulardii is currently licensed for use in humans. Recently, some researchers started using S. boulardii as heterologous protein expression systems. Combined with their probiotic activity, the use of these strains as prophylactic and therapeutic proteins carriers might result in a positive combined effort to fight specific diseases. Here, we provide an overview of the current use of S. cerevisiae strains as probiotics and their mechanisms of action. We also discuss their potential to produce molecules with biotherapeutic application and the advantages and hurdles of this approach. Finally, we suggest future directions and alternatives for which the combined effort of specific immunomodulatory effects of probiotic S. cerevisiae strains and ability to express desired foreign genes would find a practical application.ProbioticsSaccharomyces cerevisiaeSaccharomyces cerevisiae var boulardiiMechanisms of actionExpression of heterologous proteinsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34762/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Palma_Mariana_etal_INI_2015.pdfve_Palma_Mariana_etal_INI_2015.pdfapplication/pdf368635https://www.arca.fiocruz.br/bitstream/icict/34762/2/ve_Palma_Mariana_etal_INI_2015.pdf80e98a505f4962b36062533902168e0cMD52TEXTve_Palma_Mariana_etal_INI_2015.pdf.txtve_Palma_Mariana_etal_INI_2015.pdf.txtExtracted texttext/plain45144https://www.arca.fiocruz.br/bitstream/icict/34762/3/ve_Palma_Mariana_etal_INI_2015.pdf.txt0f6b2ba037a86f6a583464fe2c327d03MD53icict/347622021-03-24 16:32:35.241oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
title Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
spellingShingle Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
Palma, Mariana L.
Probiotics
Saccharomyces cerevisiae
Saccharomyces cerevisiae var boulardii
Mechanisms of action
Expression of heterologous proteins
title_short Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
title_full Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
title_fullStr Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
title_full_unstemmed Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
title_sort Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?
author Palma, Mariana L.
author_facet Palma, Mariana L.
Zamith-Miranda, Daniel
Martins, Flaviano S.
Bozza, Fernando A.
Nimrichter, Leonardo
Montero-Lomeli, Mônica
Marques, Ernesto T. A.
Douradinha, Bruno
author_role author
author2 Zamith-Miranda, Daniel
Martins, Flaviano S.
Bozza, Fernando A.
Nimrichter, Leonardo
Montero-Lomeli, Mônica
Marques, Ernesto T. A.
Douradinha, Bruno
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Palma, Mariana L.
Zamith-Miranda, Daniel
Martins, Flaviano S.
Bozza, Fernando A.
Nimrichter, Leonardo
Montero-Lomeli, Mônica
Marques, Ernesto T. A.
Douradinha, Bruno
dc.subject.en.pt_BR.fl_str_mv Probiotics
Saccharomyces cerevisiae
Saccharomyces cerevisiae var boulardii
Mechanisms of action
Expression of heterologous proteins
topic Probiotics
Saccharomyces cerevisiae
Saccharomyces cerevisiae var boulardii
Mechanisms of action
Expression of heterologous proteins
description 2020-08-13
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-13T12:52:08Z
dc.date.available.fl_str_mv 2019-08-13T12:52:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PALMA, Mariana L. et al. Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement? Applied Microbiology and Biotechnology, v. 99, p. 6563-6570, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34762
dc.identifier.issn.pt_BR.fl_str_mv 0175-7598
dc.identifier.doi.none.fl_str_mv 10.1007/s00253-015-6776-x
dc.identifier.eissn.none.fl_str_mv 1432-0614
identifier_str_mv PALMA, Mariana L. et al. Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement? Applied Microbiology and Biotechnology, v. 99, p. 6563-6570, 2015.
0175-7598
10.1007/s00253-015-6776-x
1432-0614
url https://www.arca.fiocruz.br/handle/icict/34762
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34762/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34762/2/ve_Palma_Mariana_etal_INI_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/34762/3/ve_Palma_Mariana_etal_INI_2015.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
80e98a505f4962b36062533902168e0c
0f6b2ba037a86f6a583464fe2c327d03
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008893384589312

Registros relacionados