Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26630 |
Resumo: | École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland. |
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Benjak, AndrejAvanzi, CharlotteSingh, PushpendraLoiseau, ChloéGirma, SelfuBusso, PhilippeFontes, Amanda Nogueira BrumMiyamoto, YujiNamisato, MasakoBobosha, KidistSalgado, Claudio GuedesSilva, Moises Batista daBouth, Raquel CarvalhoFrade, Marco Andrey CiprianiBernardes Filho, FredBarreto, Josafá GonçalvesNery, José Augusto da CostaBührer-Sékula, SamiraLupien, AndréanneAl-Samie, Abdul R.Al-Qubati, YasinAlkubati, Abdul S.Bretzel, GiselaVera-Cabrera, LucioSakho, FatoumataJohnson, Christian R.Kodio, MamoudouFomba, AbdoulayeSow, Samba O.Moussa GadoKonaté, OusmaneStefani, Mariane Martins de AraújoPenna, Gerson OliveiraSuffys, Philip NoelSarno, Euzenir NunesMoraes, Milton OzórioRosa, Patrícia SammarcoBaptista, Ida Maria Foschiani DiasSpencer, John StewartAseffa, AbrahamMatsuoka, MasanoriKai, MasanoriCole, Stewart T.2018-05-24T14:43:36Z2018-05-24T14:43:36Z2018BENJAK, Andrej et al. Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae. Nature Communications, v. 9, n. 352, p. 1-11, 24 Jan. 2018.2041-1723https://www.arca.fiocruz.br/handle/icict/2663010.1038/s41467-017-02576-z2041-1723engNature Publishing GroupGenoma bacterianoMicrobiologia clínicaPatógenosMycobacterium lepraeFilogenômicaResistência antimicrobianaHanseníaseBacterial genomicsClinical microbiologyPathogensMycobacterium lepraePhylogenomicsAntimicrobial resistanceLeprosyPhylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium lepraeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleÉcole Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland / Maharaja Sayajirao University of Baroda. Department of Microbiology and Biotechnology Centre. Vadodara, Gujarat, India.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland / Swiss Tropical and Public Health Institute. Basel, Switzerland.Armauer Hansen Research Institute. Addis Ababa, Ethiopia.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.National Institute of Infectious Diseases. Leprosy Research Center. Higashimurayama, Tokyo, Japan.AUEN Polyclinic. Department of Dermatology. Nakatomi, Tokorozawa, Saitama-prefecture, Japan.Armauer Hansen Research Institute. Addis Ababa, Ethiopia.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Dermato-Imunologia. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Dermato-Imunologia. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Dermato-Imunologia. Belém, PA, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Dermatologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Dermatologia. Ribeirão Preto, SP, Brasil.Universidade Federal do Pará. Laboratório de Epidemiologia Espacial. Castanhal, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland.Ministry of Public Health and Population. Sana'a, Yemen / National Leprosy Elimination Programme. Taiz, Yemen.Ministry of Public Health and Population. Sana'a, Yemen / National Leprosy Elimination Programme. Taiz, Yemen.Ministry of Public Health and Population. Sana'a, Yemen / National Leprosy Elimination Programme. Taiz, Yemen.Ludwig-Maximilians-University. University Hospital. Division of Infectious Diseases and Tropical Medicine. Munich, Germany.Universidad Autónoma de Nuevo León. Hospital Universitario. Servicio de Dermatología. Laboratorio Interdisciplinario de Investigación Dermatológica. Monterrey, Mexico.Programme National Lèpre de Guinée. Conakry, Guinea.University of Abomey-Calavi. Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable. Jericho, Cotonou, Benin.Centre National d’Appui à la Lutte Contre la Maladie. Bamako, Mali.Centre National d’Appui à la Lutte Contre la Maladie. Bamako, Mali.Centre National d’Appui à la Lutte Contre la Maladie. Bamako, Mali.Ministry of Public Health. Programme National de Lutte contre la Lèpre. Niamey, Niger.Ministry of Public Health. Programme National de Lutte contre la Lèpre. Niamey, Niger.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil / Tropical Institute of Medicine. Mycobacteriology Unit. Department of Biomedical Sciences. Antwerp, Belgium.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Colorado State University. Department of Microbiology, Immunology, and Pathology. Fort Collins, CO, USA.Armauer Hansen Research Institute. Addis Ababa, Ethiopia.National Institute of Infectious Diseases. Leprosy Research Center. Higashimurayama, Tokyo, Japan.National Institute of Infectious Diseases. Leprosy Research Center. Higashimurayama, Tokyo, Japan.École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland.Leprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae. Although readily curable with multidrug therapy (MDT), over 200,000 new cases are still reported annually. Here, we obtain M. leprae genome sequences from DNA extracted directly from patients’ skin biopsies using a customized protocol. Comparative and phylogenetic analysis of 154 genomes from 25 countries provides insight into evolution and antimicrobial resistance, uncovering lineages and phylogeographic trends, with the most ancestral strains linked to the Far East. In addition to known MDT-resistance mutations, we detect other mutations associated with antibiotic resistance, and retrace a potential stepwise emergence of extensive drug resistance in the pre-MDT era. Some of the previously undescribed mutations occur in genes that are apparently subject to positive selection, and two of these (ribD, fadD9) are restricted to drug-resistant strains. Finally, nonsense mutations in the nth excision repair gene are associated with greater sequence diversity and drug resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26630/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmiltonO-moraes_etal_IOC_2017.pdfmiltonO-moraes_etal_IOC_2017.pdfapplication/pdf861494https://www.arca.fiocruz.br/bitstream/icict/26630/2/miltonO-moraes_etal_IOC_2017.pdfc3536446f3e009583aa02fcc1b0a5102MD52TEXTmiltonO-moraes_etal_IOC_2017.pdf.txtmiltonO-moraes_etal_IOC_2017.pdf.txtExtracted texttext/plain65383https://www.arca.fiocruz.br/bitstream/icict/26630/3/miltonO-moraes_etal_IOC_2017.pdf.txt3c906aa194e796c81450cb2c5636ebd0MD53icict/266302022-06-24 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| dc.title.en.fl_str_mv |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| title |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| spellingShingle |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae Benjak, Andrej Genoma bacteriano Microbiologia clínica Patógenos Mycobacterium leprae Filogenômica Resistência antimicrobiana Hanseníase Bacterial genomics Clinical microbiology Pathogens Mycobacterium leprae Phylogenomics Antimicrobial resistance Leprosy |
| title_short |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| title_full |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| title_fullStr |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| title_full_unstemmed |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| title_sort |
Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae |
| author |
Benjak, Andrej |
| author_facet |
Benjak, Andrej Avanzi, Charlotte Singh, Pushpendra Loiseau, Chloé Girma, Selfu Busso, Philippe Fontes, Amanda Nogueira Brum Miyamoto, Yuji Namisato, Masako Bobosha, Kidist Salgado, Claudio Guedes Silva, Moises Batista da Bouth, Raquel Carvalho Frade, Marco Andrey Cipriani Bernardes Filho, Fred Barreto, Josafá Gonçalves Nery, José Augusto da Costa Bührer-Sékula, Samira Lupien, Andréanne Al-Samie, Abdul R. Al-Qubati, Yasin Alkubati, Abdul S. Bretzel, Gisela Vera-Cabrera, Lucio Sakho, Fatoumata Johnson, Christian R. Kodio, Mamoudou Fomba, Abdoulaye Sow, Samba O. Moussa Gado Konaté, Ousmane Stefani, Mariane Martins de Araújo Penna, Gerson Oliveira Suffys, Philip Noel Sarno, Euzenir Nunes Moraes, Milton Ozório Rosa, Patrícia Sammarco Baptista, Ida Maria Foschiani Dias Spencer, John Stewart Aseffa, Abraham Matsuoka, Masanori Kai, Masanori Cole, Stewart T. |
| author_role |
author |
| author2 |
Avanzi, Charlotte Singh, Pushpendra Loiseau, Chloé Girma, Selfu Busso, Philippe Fontes, Amanda Nogueira Brum Miyamoto, Yuji Namisato, Masako Bobosha, Kidist Salgado, Claudio Guedes Silva, Moises Batista da Bouth, Raquel Carvalho Frade, Marco Andrey Cipriani Bernardes Filho, Fred Barreto, Josafá Gonçalves Nery, José Augusto da Costa Bührer-Sékula, Samira Lupien, Andréanne Al-Samie, Abdul R. Al-Qubati, Yasin Alkubati, Abdul S. Bretzel, Gisela Vera-Cabrera, Lucio Sakho, Fatoumata Johnson, Christian R. Kodio, Mamoudou Fomba, Abdoulaye Sow, Samba O. Moussa Gado Konaté, Ousmane Stefani, Mariane Martins de Araújo Penna, Gerson Oliveira Suffys, Philip Noel Sarno, Euzenir Nunes Moraes, Milton Ozório Rosa, Patrícia Sammarco Baptista, Ida Maria Foschiani Dias Spencer, John Stewart Aseffa, Abraham Matsuoka, Masanori Kai, Masanori Cole, Stewart T. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Benjak, Andrej Avanzi, Charlotte Singh, Pushpendra Loiseau, Chloé Girma, Selfu Busso, Philippe Fontes, Amanda Nogueira Brum Miyamoto, Yuji Namisato, Masako Bobosha, Kidist Salgado, Claudio Guedes Silva, Moises Batista da Bouth, Raquel Carvalho Frade, Marco Andrey Cipriani Bernardes Filho, Fred Barreto, Josafá Gonçalves Nery, José Augusto da Costa Bührer-Sékula, Samira Lupien, Andréanne Al-Samie, Abdul R. Al-Qubati, Yasin Alkubati, Abdul S. Bretzel, Gisela Vera-Cabrera, Lucio Sakho, Fatoumata Johnson, Christian R. Kodio, Mamoudou Fomba, Abdoulaye Sow, Samba O. Moussa Gado Konaté, Ousmane Stefani, Mariane Martins de Araújo Penna, Gerson Oliveira Suffys, Philip Noel Sarno, Euzenir Nunes Moraes, Milton Ozório Rosa, Patrícia Sammarco Baptista, Ida Maria Foschiani Dias Spencer, John Stewart Aseffa, Abraham Matsuoka, Masanori Kai, Masanori Cole, Stewart T. |
| dc.subject.other.pt_BR.fl_str_mv |
Genoma bacteriano Microbiologia clínica Patógenos Mycobacterium leprae Filogenômica Resistência antimicrobiana Hanseníase |
| topic |
Genoma bacteriano Microbiologia clínica Patógenos Mycobacterium leprae Filogenômica Resistência antimicrobiana Hanseníase Bacterial genomics Clinical microbiology Pathogens Mycobacterium leprae Phylogenomics Antimicrobial resistance Leprosy |
| dc.subject.en.en.fl_str_mv |
Bacterial genomics Clinical microbiology Pathogens Mycobacterium leprae Phylogenomics Antimicrobial resistance Leprosy |
| description |
École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland. |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-05-24T14:43:36Z |
| dc.date.available.fl_str_mv |
2018-05-24T14:43:36Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BENJAK, Andrej et al. Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae. Nature Communications, v. 9, n. 352, p. 1-11, 24 Jan. 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26630 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2041-1723 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1038/s41467-017-02576-z |
| dc.identifier.eissn.pt_BR.fl_str_mv |
2041-1723 |
| identifier_str_mv |
BENJAK, Andrej et al. Phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae. Nature Communications, v. 9, n. 352, p. 1-11, 24 Jan. 2018. 2041-1723 10.1038/s41467-017-02576-z |
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https://www.arca.fiocruz.br/handle/icict/26630 |
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eng |
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eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/26630/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/26630/2/miltonO-moraes_etal_IOC_2017.pdf https://www.arca.fiocruz.br/bitstream/icict/26630/3/miltonO-moraes_etal_IOC_2017.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 c3536446f3e009583aa02fcc1b0a5102 3c906aa194e796c81450cb2c5636ebd0 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008951782932480 |