Microproteins in skeletal muscle: hidden keys in muscle physiology
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50343 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. |
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Bonilauri, BernardoDallagiovanna, Bruno2021-12-13T17:24:50Z2021-12-13T17:24:50Z2021BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021.2190-6009https://www.arca.fiocruz.br/handle/icict/5034310.1002/jcsm.12866porWiley Open AccessMicroproteínasMicroproteinsRNA, Long NoncodingOpen Reading FramesMuscle DevelopmentARN Largo no CodificanteSistemas de Lectura AbiertaDesarrollo de MúsculosARN long non codantCadres ouverts de lectureDéveloppement musculaireRNA Longo não CodificanteFases de Leitura AbertaDesenvolvimento MuscularMicroproteins in skeletal muscle: hidden keys in muscle physiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Recent advances in the transcriptomics, translatomics, and proteomics have led us to the exciting new world of functional endogenous microproteins. These microproteins have a small size and are derived from small open reading frames (smORFs) of RNAs previously annotated as non-coding (e.g. lncRNAs and circRNAs) as well as from untranslated regions and canonical mRNAs. The presence of these microproteins reveals a much larger translatable portion of the genome, shifting previously defined dogmas and paradigms. These findings affect our view of organisms as a whole, including skeletal muscle tissue. Emerging evidence demonstrates that several smORF-derived microproteins play crucial roles during muscle development (myogenesis), maintenance, and regeneration, as well as lipid and glucose metabolism and skeletal muscle bioenergetics. These microproteins are also involved in processes including physical activity capacity, cellular stress, and muscular-related diseases (i.e. myopathy, cachexia, atrophy, and muscle wasting). Given the role of these small proteins as important key regulators of several skeletal muscle processes, there are rich prospects for the discovery of new microproteins and possible therapies using synthetic microproteins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50343/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALjcsm.12866ok.pdfjcsm.12866ok.pdfapplication/pdf647807https://www.arca.fiocruz.br/bitstream/icict/50343/2/jcsm.12866ok.pdf02b1d454ef2ee8a2c08bd2630c87a4fcMD52icict/503432021-12-13 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dc.title.pt_BR.fl_str_mv |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
title |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
spellingShingle |
Microproteins in skeletal muscle: hidden keys in muscle physiology Bonilauri, Bernardo Microproteínas Microproteins RNA, Long Noncoding Open Reading Frames Muscle Development ARN Largo no Codificante Sistemas de Lectura Abierta Desarrollo de Músculos ARN long non codant Cadres ouverts de lecture Développement musculaire RNA Longo não Codificante Fases de Leitura Aberta Desenvolvimento Muscular |
title_short |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
title_full |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
title_fullStr |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
title_full_unstemmed |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
title_sort |
Microproteins in skeletal muscle: hidden keys in muscle physiology |
author |
Bonilauri, Bernardo |
author_facet |
Bonilauri, Bernardo Dallagiovanna, Bruno |
author_role |
author |
author2 |
Dallagiovanna, Bruno |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Bonilauri, Bernardo Dallagiovanna, Bruno |
dc.subject.other.pt_BR.fl_str_mv |
Microproteínas |
topic |
Microproteínas Microproteins RNA, Long Noncoding Open Reading Frames Muscle Development ARN Largo no Codificante Sistemas de Lectura Abierta Desarrollo de Músculos ARN long non codant Cadres ouverts de lecture Développement musculaire RNA Longo não Codificante Fases de Leitura Aberta Desenvolvimento Muscular |
dc.subject.en.pt_BR.fl_str_mv |
Microproteins RNA, Long Noncoding Open Reading Frames Muscle Development |
dc.subject.es.pt_BR.fl_str_mv |
ARN Largo no Codificante Sistemas de Lectura Abierta Desarrollo de Músculos |
dc.subject.fr.pt_BR.fl_str_mv |
ARN long non codant Cadres ouverts de lecture Développement musculaire |
dc.subject.decs.pt_BR.fl_str_mv |
RNA Longo não Codificante Fases de Leitura Aberta Desenvolvimento Muscular |
description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-13T17:24:50Z |
dc.date.available.fl_str_mv |
2021-12-13T17:24:50Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50343 |
dc.identifier.issn.pt_BR.fl_str_mv |
2190-6009 |
dc.identifier.doi.none.fl_str_mv |
10.1002/jcsm.12866 |
identifier_str_mv |
BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021. 2190-6009 10.1002/jcsm.12866 |
url |
https://www.arca.fiocruz.br/handle/icict/50343 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley Open Access |
publisher.none.fl_str_mv |
Wiley Open Access |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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