TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia

Detalhes bibliográficos
Autor(a) principal: Santiago, Rayra Pereira
Data de Publicação: 2020
Outros Autores: Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhães, Yahouédéhou, Sétondji Cocou Modeste Alexandre, Oliveira, Rodrigo Mota, Aleluia, Milena Magalhães, Carvalho, Suellen Pinheiro, Fonseca, Cleverson Alves, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Guarda, Caroline Conceição, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45782
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 (RPS, SCMAY, and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 470959/2014-2 and 405595/2016-6) through a grant to MSG. We would like to thank all the SCA individuals who agreed to participate in our research protocol. We also thank the staff of the Bahia State Hematology and Hemotherapy Foundation (HEMOBA) for their assistance with sample collection and for caring for SCA individuals.
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spelling Santiago, Rayra PereiraFigueiredo, Camylla Vilas BoasFiuza, Luciana MagalhãesYahouédéhou, Sétondji Cocou Modeste AlexandreOliveira, Rodrigo MotaAleluia, Milena MagalhãesCarvalho, Suellen PinheiroFonseca, Cleverson AlvesNascimento, Valma Maria LopesRocha, Larissa CarneiroGuarda, Caroline ConceiçãoGonçalves, Marilda de Souza2021-01-22T13:20:57Z2021-01-22T13:20:57Z2020SANTIAGO, Rayra Pereira et al. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers, p. 1-9, 2020.0278-0240https://www.arca.fiocruz.br/handle/icict/4578210.1155/2020/8867986Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 (RPS, SCMAY, and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 470959/2014-2 and 405595/2016-6) through a grant to MSG. We would like to thank all the SCA individuals who agreed to participate in our research protocol. We also thank the staff of the Bahia State Hematology and Hemotherapy Foundation (HEMOBA) for their assistance with sample collection and for caring for SCA individuals.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia do Estado da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway. Thus, we aimed to investigate polymorphisms (rs1805110 and rs7526590) of the transforming growth factor beta receptor III gene (TGFBR3) with regard to laboratory biomarkers and clinical manifestations in individuals with SCA. Hematological, biochemical, immunological, and genetic analyses were carried out, as well as serum endothelin-1 measurements. The minor allele (A) of the TGFBR3 rs1805110 polymorphism was associated with increased hemoglobin, hematocrit, reticulocyte counts, total cholesterol, low-density lipoprotein, uric acid, and endothelin levels, as well as decreased platelet distribution width (PDW) and the occurrence of bone alterations. The minor allele (T) of TGFBR3 rs7526590 was associated with increased red cell distribution width, PDW, alkaline phosphatase, aspartate aminotransferase, total and indirect bilirubin, and lactate dehydrogenase levels, as well as lower ferritin levels and the occurrence of leg ulcers. Our data suggest that the minor allele (A) of TGFBR3 rs1805110 is associated with inflammation and bone alterations, while the minor allele (T) of TGFBR3 rs7526590 is related to hemolysis and the occurrence of leg ulcers.engHindawiPolimorfismosAnemia falciformeBiomarcadores de laboratórioPolymorphismsAnemia Sickle CellBiomarkersTGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45782/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSantiago, Pereira Rayra. TGFBR3 Polymorphisms....pdfSantiago, Pereira Rayra. 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dc.title.pt_BR.fl_str_mv TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
title TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
spellingShingle TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
Santiago, Rayra Pereira
Polimorfismos
Anemia falciforme
Biomarcadores de laboratório
Polymorphisms
Anemia Sickle Cell
Biomarkers
title_short TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
title_full TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
title_fullStr TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
title_full_unstemmed TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
title_sort TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
author Santiago, Rayra Pereira
author_facet Santiago, Rayra Pereira
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Yahouédéhou, Sétondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota
Aleluia, Milena Magalhães
Carvalho, Suellen Pinheiro
Fonseca, Cleverson Alves
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Guarda, Caroline Conceição
Gonçalves, Marilda de Souza
author_role author
author2 Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Yahouédéhou, Sétondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota
Aleluia, Milena Magalhães
Carvalho, Suellen Pinheiro
Fonseca, Cleverson Alves
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Guarda, Caroline Conceição
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santiago, Rayra Pereira
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Yahouédéhou, Sétondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota
Aleluia, Milena Magalhães
Carvalho, Suellen Pinheiro
Fonseca, Cleverson Alves
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Guarda, Caroline Conceição
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Polimorfismos
Anemia falciforme
Biomarcadores de laboratório
topic Polimorfismos
Anemia falciforme
Biomarcadores de laboratório
Polymorphisms
Anemia Sickle Cell
Biomarkers
dc.subject.en.pt_BR.fl_str_mv Polymorphisms
Anemia Sickle Cell
Biomarkers
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 (RPS, SCMAY, and SPC). The study was also supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 470959/2014-2 and 405595/2016-6) through a grant to MSG. We would like to thank all the SCA individuals who agreed to participate in our research protocol. We also thank the staff of the Bahia State Hematology and Hemotherapy Foundation (HEMOBA) for their assistance with sample collection and for caring for SCA individuals.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-22T13:20:57Z
dc.date.available.fl_str_mv 2021-01-22T13:20:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTIAGO, Rayra Pereira et al. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers, p. 1-9, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45782
dc.identifier.issn.pt_BR.fl_str_mv 0278-0240
dc.identifier.doi.none.fl_str_mv 10.1155/2020/8867986
identifier_str_mv SANTIAGO, Rayra Pereira et al. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers, p. 1-9, 2020.
0278-0240
10.1155/2020/8867986
url https://www.arca.fiocruz.br/handle/icict/45782
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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