Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7559 |
Resumo: | University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil |
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Paraná, RaymundoCodes, LianaAndrade, Zilton de AraújoFreitas, Luiz Antonio Rodrigues deJesus, Rogério SantosReis, Mitermayer Galvão dosCotrim, Helma PinchemelCunha, SimoneTrépo, Christian2014-04-30T16:31:43Z2014-04-30T16:31:43Z2003PARANÁ, R. et al. Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? International Journal of Infectious Disease, v. 7, n. 3, p. 222-230, 2003.1201-9712https://www.arca.fiocruz.br/handle/icict/7559engInternational Society for Infectious DiseasesClinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, BrasilUniversity Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, BrasilUniversity Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, BrasilInserm U. Lyon, FranceNon-A-E hepatitis and acute cryptogenic hepatitis are the names given to the disease of patients with clinical hepatitis, but in whom serologic evidence of A-E hepatitis has not been found. Over a period of 8 years, we evaluated in Brazil 32 patients who fulfilled the criteria for this diagnosis in order to determine patterns of the clinical illness, laboratory parameters, or histologic features. Each patient was subjected to virologic tests to exclude A-E hepatitis and cytomegalovirus/Epstein-Barr virus infection. Drug-induced hepatitis and autoimmune disease were also excluded. Wilson's disease was excluded in young patients. The course of the disease was clinical/biochemical recovery in 3 months in 25 patients and persistent alanine aminotransferase (ALT) elevation in 7 patients. Three of these had chronic hepatitis, and one had severe fibrosis on liver biopsy. During the acute illness, mean peak ALT was 1267 IU/L, bilirubin was 4.0 mg/dL, and ferritin was 1393 IU/mL. GB virus type C (GBV-C) was found in six patients, and TT virus (TTV) in five patients. We conclude that, in Brazil, non-A-E hepatitis probably originates from still unidentified viruses. The course of the disease and the histologic patterns are similar to those recorded for known viruses. Continuous survey for the specific etiologic agents is needed.Vírus GB C/isolamento & purificaçãoHepatite Viral Humana/fisiopatologiaHepatite Viral Humana/virologiaTorque teno virus/isolamento & purificaçãoDoença AgudaAdolescenteAdultoAlanina Transaminase/sangueAnticorpos Antivirais/sangueBrasilCriançaEstudos de CoortesDoenças Transmissíveis/virologiaFemininoHepatite Viral Humana/imunologiaHumanosFígado/patologiaMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALParana R Clinical histologic....pdfParana R Clinical histologic....pdfapplication/pdf7348682https://www.arca.fiocruz.br/bitstream/icict/7559/1/Parana%20R%20Clinical%20histologic....pdf1bbf60958c3341eb500e3ec1b1a62f1dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7559/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTParana R Clinical histologic....pdf.txtParana R Clinical histologic....pdf.txtExtracted texttext/plain28619https://www.arca.fiocruz.br/bitstream/icict/7559/5/Parana%20R%20Clinical%20histologic....pdf.txtb6d7fa831c1720403ee0c6a37c5977ffMD55THUMBNAILParana R Clinical histologic....pdf.jpgParana R Clinical histologic....pdf.jpgGenerated Thumbnailimage/jpeg2644https://www.arca.fiocruz.br/bitstream/icict/7559/4/Parana%20R%20Clinical%20histologic....pdf.jpge360dc1d49a67c325863c14a047a3339MD54icict/75592023-03-15 14:33:19.09oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| title |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| spellingShingle |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? Paraná, Raymundo Vírus GB C/isolamento & purificação Hepatite Viral Humana/fisiopatologia Hepatite Viral Humana/virologia Torque teno virus/isolamento & purificação Doença Aguda Adolescente Adulto Alanina Transaminase/sangue Anticorpos Antivirais/sangue Brasil Criança Estudos de Coortes Doenças Transmissíveis/virologia Feminino Hepatite Viral Humana/imunologia Humanos Fígado/patologia Masculino Meia-Idade |
| title_short |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| title_full |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| title_fullStr |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| title_full_unstemmed |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| title_sort |
Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? |
| author |
Paraná, Raymundo |
| author_facet |
Paraná, Raymundo Codes, Liana Andrade, Zilton de Araújo Freitas, Luiz Antonio Rodrigues de Jesus, Rogério Santos Reis, Mitermayer Galvão dos Cotrim, Helma Pinchemel Cunha, Simone Trépo, Christian |
| author_role |
author |
| author2 |
Codes, Liana Andrade, Zilton de Araújo Freitas, Luiz Antonio Rodrigues de Jesus, Rogério Santos Reis, Mitermayer Galvão dos Cotrim, Helma Pinchemel Cunha, Simone Trépo, Christian |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paraná, Raymundo Codes, Liana Andrade, Zilton de Araújo Freitas, Luiz Antonio Rodrigues de Jesus, Rogério Santos Reis, Mitermayer Galvão dos Cotrim, Helma Pinchemel Cunha, Simone Trépo, Christian |
| dc.subject.decs.pt_BR.fl_str_mv |
Vírus GB C/isolamento & purificação Hepatite Viral Humana/fisiopatologia Hepatite Viral Humana/virologia Torque teno virus/isolamento & purificação Doença Aguda Adolescente Adulto Alanina Transaminase/sangue Anticorpos Antivirais/sangue Brasil Criança Estudos de Coortes Doenças Transmissíveis/virologia Feminino Hepatite Viral Humana/imunologia Humanos Fígado/patologia Masculino Meia-Idade |
| topic |
Vírus GB C/isolamento & purificação Hepatite Viral Humana/fisiopatologia Hepatite Viral Humana/virologia Torque teno virus/isolamento & purificação Doença Aguda Adolescente Adulto Alanina Transaminase/sangue Anticorpos Antivirais/sangue Brasil Criança Estudos de Coortes Doenças Transmissíveis/virologia Feminino Hepatite Viral Humana/imunologia Humanos Fígado/patologia Masculino Meia-Idade |
| description |
University Hospital of Bahia. Gastro-Hepatology Unit. Salvador, BA, Brasil / CPgMS-UFBA. Salvador, BA, Brasil |
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2003 |
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2003 |
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2014-04-30T16:31:43Z |
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2014-04-30T16:31:43Z |
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info:eu-repo/semantics/article |
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article |
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PARANÁ, R. et al. Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? International Journal of Infectious Disease, v. 7, n. 3, p. 222-230, 2003. |
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https://www.arca.fiocruz.br/handle/icict/7559 |
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1201-9712 |
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PARANÁ, R. et al. Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? International Journal of Infectious Disease, v. 7, n. 3, p. 222-230, 2003. 1201-9712 |
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International Society for Infectious Diseases |
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International Society for Infectious Diseases |
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