Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

Detalhes bibliográficos
Autor(a) principal: Souza, William Marciel de
Data de Publicação: 2018
Outros Autores: Romeiro, Marilia Farignoli, Sabino-Santos Jr, Gilberto, Maia, Felipe Gonçalves Motta, Fumagalli, Marcílio Jorge, Modha, Sejal, Nunes, Marcio Roberto Teixeira, Murcia, Pablo Ramiro, Figueiredo, Luiz Tadeu Moraes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/3168
Resumo: The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.
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spelling Souza, William Marciel deRomeiro, Marilia FarignoliSabino-Santos Jr, GilbertoMaia, Felipe Gonçalves MottaFumagalli, Marcílio JorgeModha, SejalNunes, Marcio Roberto TeixeiraMurcia, Pablo RamiroFigueiredo, Luiz Tadeu Moraes2018-06-14T12:26:49Z2018-06-14T12:26:49Z2018SOUZA, William Marciel de et al. Novel orthohepeviruses in wild rodents from São Paulo State, Brazil. Virology, v. 519, p. 12-19, June 2018.0042-6822https://patua.iec.gov.br/handle/iec/316810.1016/j.virol.2018.03.025The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number. 13/14929-1, and Scholarships No. 17/13981-0; 12/24150-9; 15/05778-5; 14/20851-8; 16/01414-1; 06/00572-0; 08/06411-4 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9).University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / MRC-University of Glasgow Centre for Virus Research. Glasgow, United Kingdom.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / University of São Paulo. Laboratory Institute of Biomedical Sciences. São Paulo, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.MRC-University of Glasgow Centre for Virus Research. Glasgow, United Kingdom.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil.MRC-University of Glasgow Centre for Virus Research. Glasgow, United Kingdom.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.engElsevierNovel orthohepeviruses in wild rodents from São Paulo State, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHepatite / diagnósticoVírus de Hepatite / isolamento & purificaçãoRoedores / virologiaHepatite Viral Humana / virologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdfNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdfapplication/pdf410409https://patua.iec.gov.br/bitstreams/eb7fa0e4-ef96-43d2-a1fb-7b217fe85523/download4ba9c8a512686a7d13958c7e996823d8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/7038078a-27b4-47dd-bd31-ea6547f945c7/download52f1732ea66fbd1123abe39f5373b797MD52TEXTNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdf.txtNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdf.txtExtracted texttext/plain27528https://patua.iec.gov.br/bitstreams/0fe7bb8c-6e24-463f-bd11-5b84d572226e/downloadaec5eca7f4cc3bd510f1c5a351e5ddd0MD55THUMBNAILNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdf.jpgNovel orthohepeviruses in wild rodents from São Paulo State, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5764https://patua.iec.gov.br/bitstreams/22ee3569-01a8-4341-97cf-06856b215e7c/download5b9bcd03a9d87655e026cf19237f916eMD56iec/31682022-10-20 21:23:15.852oai:patua.iec.gov.br:iec/3168https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:23:15Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
title Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
spellingShingle Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
Souza, William Marciel de
Hepatite / diagnóstico
Vírus de Hepatite / isolamento & purificação
Roedores / virologia
Hepatite Viral Humana / virologia
title_short Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
title_full Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
title_fullStr Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
title_full_unstemmed Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
title_sort Novel orthohepeviruses in wild rodents from São Paulo State, Brazil
author Souza, William Marciel de
author_facet Souza, William Marciel de
Romeiro, Marilia Farignoli
Sabino-Santos Jr, Gilberto
Maia, Felipe Gonçalves Motta
Fumagalli, Marcílio Jorge
Modha, Sejal
Nunes, Marcio Roberto Teixeira
Murcia, Pablo Ramiro
Figueiredo, Luiz Tadeu Moraes
author_role author
author2 Romeiro, Marilia Farignoli
Sabino-Santos Jr, Gilberto
Maia, Felipe Gonçalves Motta
Fumagalli, Marcílio Jorge
Modha, Sejal
Nunes, Marcio Roberto Teixeira
Murcia, Pablo Ramiro
Figueiredo, Luiz Tadeu Moraes
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, William Marciel de
Romeiro, Marilia Farignoli
Sabino-Santos Jr, Gilberto
Maia, Felipe Gonçalves Motta
Fumagalli, Marcílio Jorge
Modha, Sejal
Nunes, Marcio Roberto Teixeira
Murcia, Pablo Ramiro
Figueiredo, Luiz Tadeu Moraes
dc.subject.decsPrimary.pt_BR.fl_str_mv Hepatite / diagnóstico
Vírus de Hepatite / isolamento & purificação
Roedores / virologia
Hepatite Viral Humana / virologia
topic Hepatite / diagnóstico
Vírus de Hepatite / isolamento & purificação
Roedores / virologia
Hepatite Viral Humana / virologia
description The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-06-14T12:26:49Z
dc.date.available.fl_str_mv 2018-06-14T12:26:49Z
dc.date.issued.fl_str_mv 2018
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dc.identifier.citation.fl_str_mv SOUZA, William Marciel de et al. Novel orthohepeviruses in wild rodents from São Paulo State, Brazil. Virology, v. 519, p. 12-19, June 2018.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3168
dc.identifier.issn.-.fl_str_mv 0042-6822
dc.identifier.doi.-.fl_str_mv 10.1016/j.virol.2018.03.025
identifier_str_mv SOUZA, William Marciel de et al. Novel orthohepeviruses in wild rodents from São Paulo State, Brazil. Virology, v. 519, p. 12-19, June 2018.
0042-6822
10.1016/j.virol.2018.03.025
url https://patua.iec.gov.br/handle/iec/3168
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