MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma

Detalhes bibliográficos
Autor(a) principal: Fernandes, Juliana Dumet
Data de Publicação: 2015
Outros Autores: Hsieh, Ricardo, Freitas, Luiz Antonio Rodrigues de, Brandao, Miguel Angelo Rodrigues, Lourenço, Silvia Vanessa, Sangueza, Martin, Nico, Marcello Menta Simonsen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20055
Resumo: Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Fernandes, Juliana DumetHsieh, RicardoFreitas, Luiz Antonio Rodrigues deBrandao, Miguel Angelo RodriguesLourenço, Silvia VanessaSangueza, MartinNico, Marcello Menta Simonsen2017-07-12T16:51:53Z2017-07-12T16:51:53Z2015FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015.0193-1091https://www.arca.fiocruz.br/handle/icict/2005510.1097/DAD.0000000000000317Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Federal University of Bahia. Medical School. Department of Dermatology. Salvador, BA, BrazilUniversity of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, BrazilFederal University of Bahia. Medical School. Department of Pathology. Salvador, BA, BrazilAMO. Oncological Clinic Care. Salvador, BA, BrazilUniversity of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil / University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, BrazilHospital Obrero. Department of Surgical Pathology. La Paz, BoliviaUniversity of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, BrazilThe etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas. The authors examined the components of the RAS-RAF-MEK-ERK cascades by immunohistochemistry in a series of 16 primary acral melanomas by tissue microarray. The expression of MAP kinase cascade proteins changed in most cases. The authors observed that 57.14% of cases were BRAF positive and that 61.53%, 71.42%, and 71.42% of cases were positive for MEK2, ERK1, and ERK2, respectively; RAS was not expressed in 92.31%, and all cases were negative for MEK1. The absence of RAS and positivity for MEK2, ERK1, and ERK2 were most seen in invasive cases with high thickness. These aspects of the MAPK pathway require further examination in acral melanomas between different populations. Nevertheless, the results highlight significant alterations in the MAP kinase cascades that are related to histological indicators of prognosis in primary acral melanomas.engLippincott, Williams & WilkinsMelanomaAcralCâncer de peleMAPK quinasesMelanomaAcralSkin cancerMAPK kinaseMAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20055/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandes JD MAP kinase pathways.pdfFernandes JD MAP kinase pathways.pdfapplication/pdf410090https://www.arca.fiocruz.br/bitstream/icict/20055/2/Fernandes%20JD%20%20MAP%20kinase%20pathways.pdf9dd1732a2a2b04a3e40d25b66810022dMD52TEXTFernandes JD MAP kinase 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dc.title.pt_BR.fl_str_mv MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
title MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
spellingShingle MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
Fernandes, Juliana Dumet
Melanoma
Acral
Câncer de pele
MAPK quinases
Melanoma
Acral
Skin cancer
MAPK kinase
title_short MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
title_full MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
title_fullStr MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
title_full_unstemmed MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
title_sort MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
author Fernandes, Juliana Dumet
author_facet Fernandes, Juliana Dumet
Hsieh, Ricardo
Freitas, Luiz Antonio Rodrigues de
Brandao, Miguel Angelo Rodrigues
Lourenço, Silvia Vanessa
Sangueza, Martin
Nico, Marcello Menta Simonsen
author_role author
author2 Hsieh, Ricardo
Freitas, Luiz Antonio Rodrigues de
Brandao, Miguel Angelo Rodrigues
Lourenço, Silvia Vanessa
Sangueza, Martin
Nico, Marcello Menta Simonsen
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Juliana Dumet
Hsieh, Ricardo
Freitas, Luiz Antonio Rodrigues de
Brandao, Miguel Angelo Rodrigues
Lourenço, Silvia Vanessa
Sangueza, Martin
Nico, Marcello Menta Simonsen
dc.subject.other.pt_BR.fl_str_mv Melanoma
Acral
Câncer de pele
MAPK quinases
topic Melanoma
Acral
Câncer de pele
MAPK quinases
Melanoma
Acral
Skin cancer
MAPK kinase
dc.subject.en.pt_BR.fl_str_mv Melanoma
Acral
Skin cancer
MAPK kinase
description Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-07-12T16:51:53Z
dc.date.available.fl_str_mv 2017-07-12T16:51:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20055
dc.identifier.issn.pt_BR.fl_str_mv 0193-1091
dc.identifier.doi.none.fl_str_mv 10.1097/DAD.0000000000000317
identifier_str_mv FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015.
0193-1091
10.1097/DAD.0000000000000317
url https://www.arca.fiocruz.br/handle/icict/20055
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
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