MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20055 |
Resumo: | Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Fernandes, Juliana DumetHsieh, RicardoFreitas, Luiz Antonio Rodrigues deBrandao, Miguel Angelo RodriguesLourenço, Silvia VanessaSangueza, MartinNico, Marcello Menta Simonsen2017-07-12T16:51:53Z2017-07-12T16:51:53Z2015FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015.0193-1091https://www.arca.fiocruz.br/handle/icict/2005510.1097/DAD.0000000000000317Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Federal University of Bahia. Medical School. Department of Dermatology. Salvador, BA, BrazilUniversity of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, BrazilFederal University of Bahia. Medical School. Department of Pathology. Salvador, BA, BrazilAMO. Oncological Clinic Care. Salvador, BA, BrazilUniversity of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil / University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, BrazilHospital Obrero. Department of Surgical Pathology. La Paz, BoliviaUniversity of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, BrazilThe etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas. The authors examined the components of the RAS-RAF-MEK-ERK cascades by immunohistochemistry in a series of 16 primary acral melanomas by tissue microarray. The expression of MAP kinase cascade proteins changed in most cases. The authors observed that 57.14% of cases were BRAF positive and that 61.53%, 71.42%, and 71.42% of cases were positive for MEK2, ERK1, and ERK2, respectively; RAS was not expressed in 92.31%, and all cases were negative for MEK1. The absence of RAS and positivity for MEK2, ERK1, and ERK2 were most seen in invasive cases with high thickness. These aspects of the MAPK pathway require further examination in acral melanomas between different populations. Nevertheless, the results highlight significant alterations in the MAP kinase cascades that are related to histological indicators of prognosis in primary acral melanomas.engLippincott, Williams & WilkinsMelanomaAcralCâncer de peleMAPK quinasesMelanomaAcralSkin cancerMAPK kinaseMAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20055/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandes JD MAP kinase pathways.pdfFernandes JD MAP kinase pathways.pdfapplication/pdf410090https://www.arca.fiocruz.br/bitstream/icict/20055/2/Fernandes%20JD%20%20MAP%20kinase%20pathways.pdf9dd1732a2a2b04a3e40d25b66810022dMD52TEXTFernandes JD MAP kinase pathways.pdf.txtFernandes JD MAP kinase pathways.pdf.txtExtracted texttext/plain28536https://www.arca.fiocruz.br/bitstream/icict/20055/3/Fernandes%20JD%20%20MAP%20kinase%20pathways.pdf.txt07f7dc44f261aab1587cd2b3ec440adaMD53icict/200552023-03-15 14:34:04.269oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
title |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
spellingShingle |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma Fernandes, Juliana Dumet Melanoma Acral Câncer de pele MAPK quinases Melanoma Acral Skin cancer MAPK kinase |
title_short |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
title_full |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
title_fullStr |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
title_full_unstemmed |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
title_sort |
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma |
author |
Fernandes, Juliana Dumet |
author_facet |
Fernandes, Juliana Dumet Hsieh, Ricardo Freitas, Luiz Antonio Rodrigues de Brandao, Miguel Angelo Rodrigues Lourenço, Silvia Vanessa Sangueza, Martin Nico, Marcello Menta Simonsen |
author_role |
author |
author2 |
Hsieh, Ricardo Freitas, Luiz Antonio Rodrigues de Brandao, Miguel Angelo Rodrigues Lourenço, Silvia Vanessa Sangueza, Martin Nico, Marcello Menta Simonsen |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes, Juliana Dumet Hsieh, Ricardo Freitas, Luiz Antonio Rodrigues de Brandao, Miguel Angelo Rodrigues Lourenço, Silvia Vanessa Sangueza, Martin Nico, Marcello Menta Simonsen |
dc.subject.other.pt_BR.fl_str_mv |
Melanoma Acral Câncer de pele MAPK quinases |
topic |
Melanoma Acral Câncer de pele MAPK quinases Melanoma Acral Skin cancer MAPK kinase |
dc.subject.en.pt_BR.fl_str_mv |
Melanoma Acral Skin cancer MAPK kinase |
description |
Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-07-12T16:51:53Z |
dc.date.available.fl_str_mv |
2017-07-12T16:51:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20055 |
dc.identifier.issn.pt_BR.fl_str_mv |
0193-1091 |
dc.identifier.doi.none.fl_str_mv |
10.1097/DAD.0000000000000317 |
identifier_str_mv |
FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015. 0193-1091 10.1097/DAD.0000000000000317 |
url |
https://www.arca.fiocruz.br/handle/icict/20055 |
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eng |
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eng |
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dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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