Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma

Detalhes bibliográficos
Autor(a) principal: Caldeira Xavier-Júnior, Jose Candido [UNESP]
Data de Publicação: 2015
Outros Autores: Munhoz, Tania [UNESP], Souza, Vinicius [UNESP], Pires de Campos, Eloisa Bueno [UNESP], Stolf, Hamilton Ometto [UNESP], Alencar Marques, Mariangela Esther [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.diagnosticpathology.org/content/10/1/73
http://hdl.handle.net/11449/128321
Resumo: Background: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.
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spelling Focal invasiveness in complete histological analyses of a large acral lentiginous melanomaMelanomaDermatopathologyCancerAcral Lentiginous MelanomaBackground: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.UNESP- Universidade Estadual Paulista Radiology and Dermatology Department, Botucatu, SP, BrazilDepartment of Pathology, Botucatu Medical School, Paulista State University (UNESP), Rubião Júnior s/n 18618-970, Botucatu, SP, Brazil.Biomed Central LtdUniversidade Estadual Paulista (Unesp)Caldeira Xavier-Júnior, Jose Candido [UNESP]Munhoz, Tania [UNESP]Souza, Vinicius [UNESP]Pires de Campos, Eloisa Bueno [UNESP]Stolf, Hamilton Ometto [UNESP]Alencar Marques, Mariangela Esther [UNESP]2015-10-21T13:08:58Z2015-10-21T13:08:58Z2015-06-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://www.diagnosticpathology.org/content/10/1/73Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015.1746-1596http://hdl.handle.net/11449/12832110.1186/s13000-015-0307-zWOS:000356654300001WOS000356654300001.pdf1885384405893048Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiagnostic Pathology2.3960,818info:eu-repo/semantics/openAccess2024-09-03T13:18:43Zoai:repositorio.unesp.br:11449/128321Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
title Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
spellingShingle Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
Caldeira Xavier-Júnior, Jose Candido [UNESP]
Melanoma
Dermatopathology
Cancer
Acral Lentiginous Melanoma
title_short Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
title_full Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
title_fullStr Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
title_full_unstemmed Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
title_sort Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
author Caldeira Xavier-Júnior, Jose Candido [UNESP]
author_facet Caldeira Xavier-Júnior, Jose Candido [UNESP]
Munhoz, Tania [UNESP]
Souza, Vinicius [UNESP]
Pires de Campos, Eloisa Bueno [UNESP]
Stolf, Hamilton Ometto [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
author_role author
author2 Munhoz, Tania [UNESP]
Souza, Vinicius [UNESP]
Pires de Campos, Eloisa Bueno [UNESP]
Stolf, Hamilton Ometto [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Caldeira Xavier-Júnior, Jose Candido [UNESP]
Munhoz, Tania [UNESP]
Souza, Vinicius [UNESP]
Pires de Campos, Eloisa Bueno [UNESP]
Stolf, Hamilton Ometto [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
dc.subject.por.fl_str_mv Melanoma
Dermatopathology
Cancer
Acral Lentiginous Melanoma
topic Melanoma
Dermatopathology
Cancer
Acral Lentiginous Melanoma
description Background: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:08:58Z
2015-10-21T13:08:58Z
2015-06-20
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.diagnosticpathology.org/content/10/1/73
Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015.
1746-1596
http://hdl.handle.net/11449/128321
10.1186/s13000-015-0307-z
WOS:000356654300001
WOS000356654300001.pdf
1885384405893048
url http://www.diagnosticpathology.org/content/10/1/73
http://hdl.handle.net/11449/128321
identifier_str_mv Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015.
1746-1596
10.1186/s13000-015-0307-z
WOS:000356654300001
WOS000356654300001.pdf
1885384405893048
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diagnostic Pathology
2.396
0,818
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-4
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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