Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.diagnosticpathology.org/content/10/1/73 http://hdl.handle.net/11449/128321 |
Resumo: | Background: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up. |
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Focal invasiveness in complete histological analyses of a large acral lentiginous melanomaMelanomaDermatopathologyCancerAcral Lentiginous MelanomaBackground: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.UNESP- Universidade Estadual Paulista Radiology and Dermatology Department, Botucatu, SP, BrazilDepartment of Pathology, Botucatu Medical School, Paulista State University (UNESP), Rubião Júnior s/n 18618-970, Botucatu, SP, Brazil.Biomed Central LtdUniversidade Estadual Paulista (Unesp)Caldeira Xavier-Júnior, Jose Candido [UNESP]Munhoz, Tania [UNESP]Souza, Vinicius [UNESP]Pires de Campos, Eloisa Bueno [UNESP]Stolf, Hamilton Ometto [UNESP]Alencar Marques, Mariangela Esther [UNESP]2015-10-21T13:08:58Z2015-10-21T13:08:58Z2015-06-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://www.diagnosticpathology.org/content/10/1/73Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015.1746-1596http://hdl.handle.net/11449/12832110.1186/s13000-015-0307-zWOS:000356654300001WOS000356654300001.pdf1885384405893048Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiagnostic Pathology2.3960,818info:eu-repo/semantics/openAccess2024-09-03T13:18:43Zoai:repositorio.unesp.br:11449/128321Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
title |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
spellingShingle |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma Caldeira Xavier-Júnior, Jose Candido [UNESP] Melanoma Dermatopathology Cancer Acral Lentiginous Melanoma |
title_short |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
title_full |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
title_fullStr |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
title_full_unstemmed |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
title_sort |
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma |
author |
Caldeira Xavier-Júnior, Jose Candido [UNESP] |
author_facet |
Caldeira Xavier-Júnior, Jose Candido [UNESP] Munhoz, Tania [UNESP] Souza, Vinicius [UNESP] Pires de Campos, Eloisa Bueno [UNESP] Stolf, Hamilton Ometto [UNESP] Alencar Marques, Mariangela Esther [UNESP] |
author_role |
author |
author2 |
Munhoz, Tania [UNESP] Souza, Vinicius [UNESP] Pires de Campos, Eloisa Bueno [UNESP] Stolf, Hamilton Ometto [UNESP] Alencar Marques, Mariangela Esther [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Caldeira Xavier-Júnior, Jose Candido [UNESP] Munhoz, Tania [UNESP] Souza, Vinicius [UNESP] Pires de Campos, Eloisa Bueno [UNESP] Stolf, Hamilton Ometto [UNESP] Alencar Marques, Mariangela Esther [UNESP] |
dc.subject.por.fl_str_mv |
Melanoma Dermatopathology Cancer Acral Lentiginous Melanoma |
topic |
Melanoma Dermatopathology Cancer Acral Lentiginous Melanoma |
description |
Background: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:08:58Z 2015-10-21T13:08:58Z 2015-06-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.diagnosticpathology.org/content/10/1/73 Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015. 1746-1596 http://hdl.handle.net/11449/128321 10.1186/s13000-015-0307-z WOS:000356654300001 WOS000356654300001.pdf 1885384405893048 |
url |
http://www.diagnosticpathology.org/content/10/1/73 http://hdl.handle.net/11449/128321 |
identifier_str_mv |
Diagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015. 1746-1596 10.1186/s13000-015-0307-z WOS:000356654300001 WOS000356654300001.pdf 1885384405893048 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Diagnostic Pathology 2.396 0,818 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-4 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021422837268480 |