Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45499 |
Resumo: | Hematology and Hemotherapy Foundation of Bahia (HEMOBA) for the critical assistance in patient recruitment and evaluation. This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the notice number 020/201—Research Program: shared health management—(PPSUS) of Bahia (Award Number: EFP00006943). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The work of Bruno B. Andrade is supported by the Intramural Research Program of the Fundação Oswaldo Cruz. Bruno B. Andrade is a senior research fellow from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Caian L. Vinhaes received a research fellowship from the CNPq. Juan M. Cubillos-Angulo received a PhD fellowship from the Organization of American States—Partnerships Program for Education and Training (OAS-PAEC) and the Coordenação de Aperfeiçoamento de pessoal de Nível Superior Brasil (CAPES, Finance Code 001). Rafael Tibúrcio received a PhD fellowships from CAPES and María B. Arriaga received a PhD from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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Vinhaes, Caian LealTeixeira, Rozana S.Monteiro Júnior, Jay A. S.Tibúrcio, RafaelCubillos-Angulo, Juan ManuelArriaga Gutiérrez, María BelenSabarin, Adrielle G.Souza, Amâncio J. deSilva, Jacqueline J.Lyra, Isa M.Ladeia, Ana Marice TeixeiraAndrade, Bruno de Bezerril2021-01-04T18:17:57Z2021-01-04T18:17:57Z2020VINHAES, Caian Leal et al. treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia. Scientific Reports, v. 10, p. 1-10, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4549910.1038/s41598-020-76075-5Hematology and Hemotherapy Foundation of Bahia (HEMOBA) for the critical assistance in patient recruitment and evaluation. This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the notice number 020/201—Research Program: shared health management—(PPSUS) of Bahia (Award Number: EFP00006943). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The work of Bruno B. Andrade is supported by the Intramural Research Program of the Fundação Oswaldo Cruz. Bruno B. Andrade is a senior research fellow from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Caian L. Vinhaes received a research fellowship from the CNPq. Juan M. Cubillos-Angulo received a PhD fellowship from the Organization of American States—Partnerships Program for Education and Training (OAS-PAEC) and the Coordenação de Aperfeiçoamento de pessoal de Nível Superior Brasil (CAPES, Finance Code 001). Rafael Tibúrcio received a PhD fellowships from CAPES and María B. Arriaga received a PhD from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. School of Medicine. Salvador, BA, Brasil /Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil.Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil.Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil.University Salvador. Laureate International Universities. Salvador, BA, Brazil.Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Catholic University of Salvador. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. School of Medicine. Salvador, BA, Brasil / Bahia Foundation for the Development of Sciences. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Federal University of Bahia. School of Medicine. Salvador, BA, Brazil / University Salvador. Laureate International Universities, Salvador, BA, Brazil.Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidative stress in a case–control study from Brazil. To do so, a panel containing 9 oxidative stress markers was measured in plasma samples from a cohort of 47 SCA cases and 40 healthy children and adolescents. Among the SCA patients, 42.5% were undertaking hydroxyurea. Multidimensional analysis was employed to describe disease phenotypes. Our results demonstrated that SCA is associated with increased levels of oxidative stress markers, suggesting the existence of an unbalanced inflammatory response in peripheral blood. Subsequent analyses revealed that hydroxyurea therapy was associated with diminished oxidative imbalance in SCA patients. Our findings reinforce the idea that SCA is associated with a substantial dysregulation of oxidative responses which may be dampened by treatment with hydroxyurea. If validated by larger prospective studies, our observations argue that reduction of oxidative stress may be a main mechanism through which hydroxyurea therapy attenuates the tissue damage and can contribute to improved clinical outcomes in SCA.engNature ResearchHidroxiureiaAnemia falciformeCriançasAdolescentesTratamentoHydroxyureaAnemia Sickle CellChildrenAdolescentsTreatmentHydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45499/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALVinhaes, Cain L Hydroxyurea...2020.pdfVinhaes, Cain L Hydroxyurea...2020.pdfapplication/pdf2525745https://www.arca.fiocruz.br/bitstream/icict/45499/2/Vinhaes%2c%20Cain%20L%20Hydroxyurea...2020.pdf578072c3d5a08b3429cced5c4bdf9cd7MD52TEXTVinhaes, Cain L Hydroxyurea...2020.pdf.txtVinhaes, Cain L Hydroxyurea...2020.pdf.txtExtracted texttext/plain52125https://www.arca.fiocruz.br/bitstream/icict/45499/3/Vinhaes%2c%20Cain%20L%20Hydroxyurea...2020.pdf.txt49bfeacbedb3f25cafeb2a781d8a9d18MD53icict/454992023-03-15 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| dc.title.pt_BR.fl_str_mv |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| title |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| spellingShingle |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia Vinhaes, Caian Leal Hidroxiureia Anemia falciforme Crianças Adolescentes Tratamento Hydroxyurea Anemia Sickle Cell Children Adolescents Treatment |
| title_short |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| title_full |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| title_fullStr |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| title_full_unstemmed |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| title_sort |
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia |
| author |
Vinhaes, Caian Leal |
| author_facet |
Vinhaes, Caian Leal Teixeira, Rozana S. Monteiro Júnior, Jay A. S. Tibúrcio, Rafael Cubillos-Angulo, Juan Manuel Arriaga Gutiérrez, María Belen Sabarin, Adrielle G. Souza, Amâncio J. de Silva, Jacqueline J. Lyra, Isa M. Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Teixeira, Rozana S. Monteiro Júnior, Jay A. S. Tibúrcio, Rafael Cubillos-Angulo, Juan Manuel Arriaga Gutiérrez, María Belen Sabarin, Adrielle G. Souza, Amâncio J. de Silva, Jacqueline J. Lyra, Isa M. Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vinhaes, Caian Leal Teixeira, Rozana S. Monteiro Júnior, Jay A. S. Tibúrcio, Rafael Cubillos-Angulo, Juan Manuel Arriaga Gutiérrez, María Belen Sabarin, Adrielle G. Souza, Amâncio J. de Silva, Jacqueline J. Lyra, Isa M. Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril |
| dc.subject.other.pt_BR.fl_str_mv |
Hidroxiureia Anemia falciforme Crianças Adolescentes Tratamento |
| topic |
Hidroxiureia Anemia falciforme Crianças Adolescentes Tratamento Hydroxyurea Anemia Sickle Cell Children Adolescents Treatment |
| dc.subject.en.pt_BR.fl_str_mv |
Hydroxyurea Anemia Sickle Cell Children Adolescents Treatment |
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Hematology and Hemotherapy Foundation of Bahia (HEMOBA) for the critical assistance in patient recruitment and evaluation. This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) under the notice number 020/201—Research Program: shared health management—(PPSUS) of Bahia (Award Number: EFP00006943). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The work of Bruno B. Andrade is supported by the Intramural Research Program of the Fundação Oswaldo Cruz. Bruno B. Andrade is a senior research fellow from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Caian L. Vinhaes received a research fellowship from the CNPq. Juan M. Cubillos-Angulo received a PhD fellowship from the Organization of American States—Partnerships Program for Education and Training (OAS-PAEC) and the Coordenação de Aperfeiçoamento de pessoal de Nível Superior Brasil (CAPES, Finance Code 001). Rafael Tibúrcio received a PhD fellowships from CAPES and María B. Arriaga received a PhD from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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2020 |
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2020 |
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2021-01-04T18:17:57Z |
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2021-01-04T18:17:57Z |
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VINHAES, Caian Leal et al. treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia. Scientific Reports, v. 10, p. 1-10, 2020. |
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https://www.arca.fiocruz.br/handle/icict/45499 |
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2045-2322 |
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10.1038/s41598-020-76075-5 |
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VINHAES, Caian Leal et al. treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia. Scientific Reports, v. 10, p. 1-10, 2020. 2045-2322 10.1038/s41598-020-76075-5 |
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Nature Research |
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