Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions

Detalhes bibliográficos
Autor(a) principal: Portes, Leslie Andrews
Data de Publicação: 2009
Outros Autores: Saraiva, Roberto Magalhães, Santos, Alexandra Alberta dos, Tucci, Paulo J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39061
Resumo: Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
id CRUZ_b74b758ef9e67a9d19809517991394d5
oai_identifier_str oai:www.arca.fiocruz.br:icict/39061
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Portes, Leslie AndrewsSaraiva, Roberto MagalhãesSantos, Alexandra Alberta dosTucci, Paulo J. F.2020-01-08T14:02:13Z2020-01-08T14:02:13Z2009PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009.0305-1870https://www.arca.fiocruz.br/handle/icict/3906110.1111/j.1440-1681.2008.05070.x1440-1681Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2021-01-08São Paulo Adventist University. Department of Physiology. São Paulo, SP, Brazil / Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.1. The aim of the present study was to evaluate the effect of swimming on myocardial remodelling after myocardial infarction (MI) in female rats induced by coronary occlusion, which was not performed in sham rats. 2. Rats were divided in six groups, three sedentary (sham (SSh; n=14), moderate infarct (SMI; n=8) and large infarct (SLI; n=10) and three trained (sham (TSh; n=16), moderate infarct (TMI; n=9) and large infarct (TLI; n=8)) groups.Training (8 weeks, 60 min/day, 5 days/week) was initiated 4 weeks after MI or sham operation. Training did not affect mortality rate, but attenuated the increases in atrial/body weight (SSh: 0.07±0.02; TSh: 0.07±0.02; SMI: 0.11±0.03; TMI:0.09±0.03; SLI: 0.17±0.09; TLI: 0.10±0.05 mg/g) and right ventricular/bodyweight (SSh: 0.15±0.02; TSh: 0.17±0.02;SMI: 0.17±0.07; TMI: 0.20±0.03; SLI: 0.29±0.13; TLI: 0.22±0.08 mg/g) ratios. Myocardial infarction increased pulmonary and myocardial water content in infarcted sedentary animals, whereas no changes were observed in trained infarctedrats. Sedentary infarcted rats showed inotropic and lusitropic depression proportional to the size of the infarct (SSh>SMI>SLI), whereas no differences were noted in trained rats(TLI=TMI=TSh). Indeed, in sedentary rats there was depression of +dT/dt (SSh: 68±25; TSh: 72±21; SMI: 53±20; TMI:77±30; SLI: 33±15; TLI: 57±22 g/mm2 per s) and –dT/dt (SSh:33±13; TSh: 36±11; SMI: 24±5; TMI: 35±11; SLI: 15±4;TLI: 32±11 g/mm2 per s) compared with trained rats.3. In conclusion, swimming clearly favoured post-MI cardiac remodelling, attenuated myocardial hypertrophy, contractile and relaxation dysfunction and prevented pulmonary congestion.engWileySwimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleContractile dysfunctionHeart failureMyocardial infarctionSwimming traininginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39061/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Portes_Leslie_etal_INI_2009.pdfve_Portes_Leslie_etal_INI_2009.pdfapplication/pdf282453https://www.arca.fiocruz.br/bitstream/icict/39061/2/ve_Portes_Leslie_etal_INI_2009.pdf93d667abd8c5c3be3322010db6248fc4MD52TEXTve_Portes_Leslie_etal_INI_2009.pdf.txtve_Portes_Leslie_etal_INI_2009.pdf.txtExtracted texttext/plain37210https://www.arca.fiocruz.br/bitstream/icict/39061/3/ve_Portes_Leslie_etal_INI_2009.pdf.txtd5ac0cbc2c52c5988c7f09a82ca6742bMD53icict/390612021-03-24 16:32:42.305oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
title Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
spellingShingle Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
Portes, Leslie Andrews
Contractile dysfunction
Heart failure
Myocardial infarction
Swimming training
title_short Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
title_full Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
title_fullStr Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
title_full_unstemmed Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
title_sort Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
author Portes, Leslie Andrews
author_facet Portes, Leslie Andrews
Saraiva, Roberto Magalhães
Santos, Alexandra Alberta dos
Tucci, Paulo J. F.
author_role author
author2 Saraiva, Roberto Magalhães
Santos, Alexandra Alberta dos
Tucci, Paulo J. F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Portes, Leslie Andrews
Saraiva, Roberto Magalhães
Santos, Alexandra Alberta dos
Tucci, Paulo J. F.
dc.subject.en.pt_BR.fl_str_mv Contractile dysfunction
Heart failure
Myocardial infarction
Swimming training
topic Contractile dysfunction
Heart failure
Myocardial infarction
Swimming training
description Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-08T14:02:13Z
dc.date.available.fl_str_mv 2020-01-08T14:02:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39061
dc.identifier.issn.pt_BR.fl_str_mv 0305-1870
dc.identifier.doi.none.fl_str_mv 10.1111/j.1440-1681.2008.05070.x
dc.identifier.eissn.none.fl_str_mv 1440-1681
identifier_str_mv PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009.
0305-1870
10.1111/j.1440-1681.2008.05070.x
1440-1681
url https://www.arca.fiocruz.br/handle/icict/39061
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/39061/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/39061/2/ve_Portes_Leslie_etal_INI_2009.pdf
https://www.arca.fiocruz.br/bitstream/icict/39061/3/ve_Portes_Leslie_etal_INI_2009.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
93d667abd8c5c3be3322010db6248fc4
d5ac0cbc2c52c5988c7f09a82ca6742b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324658091589632

Registros relacionados