Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/39061 |
Resumo: | Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Portes, Leslie AndrewsSaraiva, Roberto MagalhãesSantos, Alexandra Alberta dosTucci, Paulo J. F.2020-01-08T14:02:13Z2020-01-08T14:02:13Z2009PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009.0305-1870https://www.arca.fiocruz.br/handle/icict/3906110.1111/j.1440-1681.2008.05070.x1440-1681Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2021-01-08São Paulo Adventist University. Department of Physiology. São Paulo, SP, Brazil / Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.1. The aim of the present study was to evaluate the effect of swimming on myocardial remodelling after myocardial infarction (MI) in female rats induced by coronary occlusion, which was not performed in sham rats. 2. Rats were divided in six groups, three sedentary (sham (SSh; n=14), moderate infarct (SMI; n=8) and large infarct (SLI; n=10) and three trained (sham (TSh; n=16), moderate infarct (TMI; n=9) and large infarct (TLI; n=8)) groups.Training (8 weeks, 60 min/day, 5 days/week) was initiated 4 weeks after MI or sham operation. Training did not affect mortality rate, but attenuated the increases in atrial/body weight (SSh: 0.07±0.02; TSh: 0.07±0.02; SMI: 0.11±0.03; TMI:0.09±0.03; SLI: 0.17±0.09; TLI: 0.10±0.05 mg/g) and right ventricular/bodyweight (SSh: 0.15±0.02; TSh: 0.17±0.02;SMI: 0.17±0.07; TMI: 0.20±0.03; SLI: 0.29±0.13; TLI: 0.22±0.08 mg/g) ratios. Myocardial infarction increased pulmonary and myocardial water content in infarcted sedentary animals, whereas no changes were observed in trained infarctedrats. Sedentary infarcted rats showed inotropic and lusitropic depression proportional to the size of the infarct (SSh>SMI>SLI), whereas no differences were noted in trained rats(TLI=TMI=TSh). Indeed, in sedentary rats there was depression of +dT/dt (SSh: 68±25; TSh: 72±21; SMI: 53±20; TMI:77±30; SLI: 33±15; TLI: 57±22 g/mm2 per s) and –dT/dt (SSh:33±13; TSh: 36±11; SMI: 24±5; TMI: 35±11; SLI: 15±4;TLI: 32±11 g/mm2 per s) compared with trained rats.3. In conclusion, swimming clearly favoured post-MI cardiac remodelling, attenuated myocardial hypertrophy, contractile and relaxation dysfunction and prevented pulmonary congestion.engWileySwimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleContractile dysfunctionHeart failureMyocardial infarctionSwimming traininginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39061/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Portes_Leslie_etal_INI_2009.pdfve_Portes_Leslie_etal_INI_2009.pdfapplication/pdf282453https://www.arca.fiocruz.br/bitstream/icict/39061/2/ve_Portes_Leslie_etal_INI_2009.pdf93d667abd8c5c3be3322010db6248fc4MD52TEXTve_Portes_Leslie_etal_INI_2009.pdf.txtve_Portes_Leslie_etal_INI_2009.pdf.txtExtracted texttext/plain37210https://www.arca.fiocruz.br/bitstream/icict/39061/3/ve_Portes_Leslie_etal_INI_2009.pdf.txtd5ac0cbc2c52c5988c7f09a82ca6742bMD53icict/390612021-03-24 16:32:42.305oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
title |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
spellingShingle |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions Portes, Leslie Andrews Contractile dysfunction Heart failure Myocardial infarction Swimming training |
title_short |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
title_full |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
title_fullStr |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
title_full_unstemmed |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
title_sort |
Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions |
author |
Portes, Leslie Andrews |
author_facet |
Portes, Leslie Andrews Saraiva, Roberto Magalhães Santos, Alexandra Alberta dos Tucci, Paulo J. F. |
author_role |
author |
author2 |
Saraiva, Roberto Magalhães Santos, Alexandra Alberta dos Tucci, Paulo J. F. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Portes, Leslie Andrews Saraiva, Roberto Magalhães Santos, Alexandra Alberta dos Tucci, Paulo J. F. |
dc.subject.en.pt_BR.fl_str_mv |
Contractile dysfunction Heart failure Myocardial infarction Swimming training |
topic |
Contractile dysfunction Heart failure Myocardial infarction Swimming training |
description |
Roberto Magalhães Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2020-01-08T14:02:13Z |
dc.date.available.fl_str_mv |
2020-01-08T14:02:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/39061 |
dc.identifier.issn.pt_BR.fl_str_mv |
0305-1870 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1440-1681.2008.05070.x |
dc.identifier.eissn.none.fl_str_mv |
1440-1681 |
identifier_str_mv |
PORTES, Leslie Andrews et al. Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions. Clinical and Experimental Pharmacology and Physiology, v. 36, p. 394-399, 2009. 0305-1870 10.1111/j.1440-1681.2008.05070.x 1440-1681 |
url |
https://www.arca.fiocruz.br/handle/icict/39061 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wiley |
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Wiley |
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