Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia

Detalhes bibliográficos
Autor(a) principal: Totino, Paulo R. R.
Data de Publicação: 2016
Outros Autores: Daniel-Ribeiro, Cláudio Tadeu, Cruz, Maria de Fátima Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17912
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
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spelling Totino, Paulo R. R.Daniel-Ribeiro, Cláudio TadeuCruz, Maria de Fátima Ferreira da2017-03-01T17:16:40Z2017-03-01T17:16:40Z2016TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016.2235-2988https://www.arca.fiocruz.br/handle/icict/1791210.3389/fcimb.2016.00176engFrontiers MediaMaláriaAnemiaApoptoseFagocitoseEritrócitosMalariaAnemiaApoptosisred blood cellsphagocytosisEvidencing the Role of Erythrocytic Apoptosis in Malarial Anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources including drug therapy and infectious diseases. In malaria, severe anemia is a common complication leading to death of children and pregnant women living in malaria-endemic regions of Africa. The pathogenesis of malarial anemia is multifactorial and involves both ineffective production of RBCs by the bone marrow and premature elimination of non-parasitized RBCs, phenomena potentially associated with apoptosis. In the present overview, we discuss evidences associating erythrocytic apoptosis with the pathogenesis of severe malarial anemia, as well as with regulation of parasite clearance in malaria. 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dc.title.pt_BR.fl_str_mv Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
title Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
spellingShingle Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
Totino, Paulo R. R.
Malária
Anemia
Apoptose
Fagocitose
Eritrócitos
Malaria
Anemia
Apoptosis
red blood cells
phagocytosis
title_short Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
title_full Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
title_fullStr Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
title_full_unstemmed Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
title_sort Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
author Totino, Paulo R. R.
author_facet Totino, Paulo R. R.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author2_role author
author
dc.contributor.author.fl_str_mv Totino, Paulo R. R.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
dc.subject.other.pt_BR.fl_str_mv Malária
Anemia
Apoptose
Fagocitose
Eritrócitos
topic Malária
Anemia
Apoptose
Fagocitose
Eritrócitos
Malaria
Anemia
Apoptosis
red blood cells
phagocytosis
dc.subject.en.pt_BR.fl_str_mv Malaria
Anemia
Apoptosis
red blood cells
phagocytosis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-01T17:16:40Z
dc.date.available.fl_str_mv 2017-03-01T17:16:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17912
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2016.00176
identifier_str_mv TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016.
2235-2988
10.3389/fcimb.2016.00176
url https://www.arca.fiocruz.br/handle/icict/17912
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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