Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17912 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. |
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Totino, Paulo R. R.Daniel-Ribeiro, Cláudio TadeuCruz, Maria de Fátima Ferreira da2017-03-01T17:16:40Z2017-03-01T17:16:40Z2016TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016.2235-2988https://www.arca.fiocruz.br/handle/icict/1791210.3389/fcimb.2016.00176engFrontiers MediaMaláriaAnemiaApoptoseFagocitoseEritrócitosMalariaAnemiaApoptosisred blood cellsphagocytosisEvidencing the Role of Erythrocytic Apoptosis in Malarial Anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources including drug therapy and infectious diseases. In malaria, severe anemia is a common complication leading to death of children and pregnant women living in malaria-endemic regions of Africa. The pathogenesis of malarial anemia is multifactorial and involves both ineffective production of RBCs by the bone marrow and premature elimination of non-parasitized RBCs, phenomena potentially associated with apoptosis. In the present overview, we discuss evidences associating erythrocytic apoptosis with the pathogenesis of severe malarial anemia, as well as with regulation of parasite clearance in malaria. Efforts to understand the role of erythrocytic apoptosis in malarial anemia can help to identify potential targets for therapeutic intervention based on apoptotic pathways and consequently, mitigate the harmful impact of malaria in global public health.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17912/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpaulo_totino_etal_IOC_2016.pdfpaulo_totino_etal_IOC_2016.pdfapplication/pdf792837https://www.arca.fiocruz.br/bitstream/icict/17912/2/paulo_totino_etal_IOC_2016.pdf4555a73bd9a12ce858b6df1101f9b869MD52TEXTpaulo_totino_etal_IOC_2016.pdf.txtpaulo_totino_etal_IOC_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
title |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
spellingShingle |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia Totino, Paulo R. R. Malária Anemia Apoptose Fagocitose Eritrócitos Malaria Anemia Apoptosis red blood cells phagocytosis |
title_short |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
title_full |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
title_fullStr |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
title_full_unstemmed |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
title_sort |
Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia |
author |
Totino, Paulo R. R. |
author_facet |
Totino, Paulo R. R. Daniel-Ribeiro, Cláudio Tadeu Cruz, Maria de Fátima Ferreira da |
author_role |
author |
author2 |
Daniel-Ribeiro, Cláudio Tadeu Cruz, Maria de Fátima Ferreira da |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Totino, Paulo R. R. Daniel-Ribeiro, Cláudio Tadeu Cruz, Maria de Fátima Ferreira da |
dc.subject.other.pt_BR.fl_str_mv |
Malária Anemia Apoptose Fagocitose Eritrócitos |
topic |
Malária Anemia Apoptose Fagocitose Eritrócitos Malaria Anemia Apoptosis red blood cells phagocytosis |
dc.subject.en.pt_BR.fl_str_mv |
Malaria Anemia Apoptosis red blood cells phagocytosis |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-03-01T17:16:40Z |
dc.date.available.fl_str_mv |
2017-03-01T17:16:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17912 |
dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2016.00176 |
identifier_str_mv |
TOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016. 2235-2988 10.3389/fcimb.2016.00176 |
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https://www.arca.fiocruz.br/handle/icict/17912 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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