Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection

Detalhes bibliográficos
Autor(a) principal: Roque, André Luiz Rodrigues
Data de Publicação: 2010
Outros Autores: Cupolillo, Elisa, Marchevsky, Renato Sergio, Jansen, Ana Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20817
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ, Brasil.
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spelling Roque, André Luiz RodriguesCupolillo, ElisaMarchevsky, Renato SergioJansen, Ana Maria2017-08-29T16:06:15Z2017-08-29T16:06:15Z2010ROQUE, André Luiz Rodrigues; et al. Thrichomys laurentius (Rodentia; Echimyidae) as a Putative Reservoir of Leishmania infantum and L. braziliensis: Patterns of Experimental Infection. PLoS Negl Trop Dis., v.4, n.2, e589., 8p, Feb. 2010.1935-2727https://www.arca.fiocruz.br/handle/icict/2081710.1371/journal.pntd.00005891935-2735engPublic Library of ScienceLeishmania braziliensisLeishmania infantumInfecçãoThrichomys laurentiusThrichomys laurentiusLeishmania infantumLeishmania braziliensisInfectionThrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Biotecnologia em Fármacos - Farmanguinhos. Laboratório de Neurovirulência. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.The importance of the genus Thrichomys in the retention of infection and transmission of Leishmania species is supported by previous studies that describe an ancient interaction between caviomorphs and trypanosomatids and report the natural infection of Thrichomys spp. Moreover, these rodents are widely dispersed in Brazil and recognized as important hosts of other tripanosomatids. Our main purpose was to evaluate the putative role of Thrichomys laurentius in the retention of infection and amplification of the transmission cycle of Leishmania infantum and L. braziliensis. Male and female T. laurentius (n = 24) born in captivity were evaluated for the retention of infection with these Leishmania species and followed up by parasitological, serological, hematological, biochemical, histological, and molecular assays for 3, 6, 9, or 12 months post infection (mpi). T. laurentius showed its competence as maintenance host for the two inoculated Leishmania species. Four aspects should be highlighted: (i) re-isolation of parasites 12 mpi; (ii) the low parasitic burden displayed by T. laurentius tissues; (iii) the early onset and maintenance of humoral response, and (iv) the similar pattern of infection by the two Leishmania species. Both Leishmania species demonstrated the ability to invade and maintain itself in viscera and skin of T. laurentius, and no rodent displayed any lesion, histological changes, or clinical evidence of infection. We also wish to point out the irrelevance of the adjective dermotropic or viscerotropic to qualify L. braziliensis and L. infantum, respectively, when these species are hosted by nonhuman hosts. Our data suggest that T. laurentius may act at least as a maintenance host of both tested Leishmania species since it maintained long-lasting infections. Moreover, it cannot be discarded that Leishmania spp. infection in free-ranging T. laurentius could result in higher parasite burden due the more stressing conditions in the wild. Therefore the tissular parasitism of the skin, infectiveness to the vector, and amplification of the transmission cycle of both Leishmania species could be expected.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20817/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALelisacupolillo_etal_IOC_2010.pdfelisacupolillo_etal_IOC_2010.pdfapplication/pdf748313https://www.arca.fiocruz.br/bitstream/icict/20817/2/elisacupolillo_etal_IOC_2010.pdf750de936f7c0b976c21696f81a74b5baMD52TEXTelisacupolillo_etal_IOC_2010.pdf.txtelisacupolillo_etal_IOC_2010.pdf.txtExtracted texttext/plain47893https://www.arca.fiocruz.br/bitstream/icict/20817/3/elisacupolillo_etal_IOC_2010.pdf.txt9f505ac2aef04370d66da5c03b4f495eMD53icict/208172018-08-15 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dc.title.pt_BR.fl_str_mv Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
title Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
spellingShingle Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
Roque, André Luiz Rodrigues
Leishmania braziliensis
Leishmania infantum
Infecção
Thrichomys laurentius
Thrichomys laurentius
Leishmania infantum
Leishmania braziliensis
Infection
title_short Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
title_full Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
title_fullStr Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
title_full_unstemmed Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
title_sort Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection
author Roque, André Luiz Rodrigues
author_facet Roque, André Luiz Rodrigues
Cupolillo, Elisa
Marchevsky, Renato Sergio
Jansen, Ana Maria
author_role author
author2 Cupolillo, Elisa
Marchevsky, Renato Sergio
Jansen, Ana Maria
author2_role author
author
author
dc.contributor.author.fl_str_mv Roque, André Luiz Rodrigues
Cupolillo, Elisa
Marchevsky, Renato Sergio
Jansen, Ana Maria
dc.subject.other.pt_BR.fl_str_mv Leishmania braziliensis
Leishmania infantum
Infecção
Thrichomys laurentius
topic Leishmania braziliensis
Leishmania infantum
Infecção
Thrichomys laurentius
Thrichomys laurentius
Leishmania infantum
Leishmania braziliensis
Infection
dc.subject.en.pt_BR.fl_str_mv Thrichomys laurentius
Leishmania infantum
Leishmania braziliensis
Infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-08-29T16:06:15Z
dc.date.available.fl_str_mv 2017-08-29T16:06:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ROQUE, André Luiz Rodrigues; et al. Thrichomys laurentius (Rodentia; Echimyidae) as a Putative Reservoir of Leishmania infantum and L. braziliensis: Patterns of Experimental Infection. PLoS Negl Trop Dis., v.4, n.2, e589., 8p, Feb. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20817
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0000589
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv ROQUE, André Luiz Rodrigues; et al. Thrichomys laurentius (Rodentia; Echimyidae) as a Putative Reservoir of Leishmania infantum and L. braziliensis: Patterns of Experimental Infection. PLoS Negl Trop Dis., v.4, n.2, e589., 8p, Feb. 2010.
1935-2727
10.1371/journal.pntd.0000589
1935-2735
url https://www.arca.fiocruz.br/handle/icict/20817
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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