Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America

Detalhes bibliográficos
Autor(a) principal: Cabello, Marina
Data de Publicação: 2015
Outros Autores: Junqueira, Dennis Maletich, Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12316
Resumo: Não se trata da versão final do artigo. AIDS - http://www.lww.com/product/?0269-9370
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spelling Cabello, MarinaJunqueira, Dennis MaletichBello, Gonzalo2015-11-24T16:55:27Z2016-02-01T06:30:07Z2015CABELLO, Marina; JUNQUEIRA, Dennis Maletich; BELLO, Gonzalo. Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America. AIDS, v.29, n.4, p.483-492, Feb. 2015.1473-5571https://www.arca.fiocruz.br/handle/icict/12316Não se trata da versão final do artigo. AIDS - http://www.lww.com/product/?0269-9370Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil / Uniritter Laureate International Universities. Departamento de Ciências da Saúde. Porto Alegre, RS, Brasil / Universidade 15 Federal do Rio Grande do Sul (UFGRS). Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM). Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.To estimate the prevalence of the HIV-1 subtype B pandemic (BPANDEMIC) and Caribbean (BCAR) clades in Latin America and to reconstruct the spatiotemporal dynamics of dissemination of the BCAR clades in the region. DESIGN: A total of 7654 HIV-1 subtype B pol sequences collected from 18 different Latin American countries between 1989 and 2011 were analyzed together with subtype B reference sequences representative of the BPANDEMIC (US/France = 300) and the BCAR (Caribbean = 279, Panama = 37) clades. METHODS: Phylogeographic and evolutionary parameters were estimated from sequence data using maximum likelihood and Bayesian coalescent-based methods. RESULTS: Nonpandemic BCAR strains were probably disseminated from the Caribbean islands of Hispaniola and Trinidad and Tobago into Latin America since the early 1970s. The BCAR strains reached nearly all countries from Latin America here analyzed and in some of them were spread locally, although their overall prevalence in the region is low. The BPANDEMIC clade comprises more than 90% of subtype B infections in most countries analyzed, with exception of Suriname, French Guyana and probably Guyana, where both BPANDEMIC and BCAR clades seem to circulate at a similar prevalence. CONCLUSION: This study demonstrates that nonpandemic subtype B lineages of Caribbean origin have been disseminated into Latin America shortly after the estimated introduction of subtype B in the continent. Despite their early dissemination, the BCAR strains account for a minor fraction of current HIV-1 subtype B infections in the region that are mainly driven by spreading of the globally disseminated BPANDEMIC clade.engLippincott, Williams & WilkinsHIV-1América LatinaFilogeografiaHIV-1subtype Bnon-pandemicphylogeographyLatin AmericaDissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
title Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
spellingShingle Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
Cabello, Marina
HIV-1
América Latina
Filogeografia
HIV-1
subtype B
non-pandemic
phylogeography
Latin America
title_short Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
title_full Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
title_fullStr Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
title_full_unstemmed Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
title_sort Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America
author Cabello, Marina
author_facet Cabello, Marina
Junqueira, Dennis Maletich
Bello, Gonzalo
author_role author
author2 Junqueira, Dennis Maletich
Bello, Gonzalo
author2_role author
author
dc.contributor.author.fl_str_mv Cabello, Marina
Junqueira, Dennis Maletich
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV-1
América Latina
Filogeografia
topic HIV-1
América Latina
Filogeografia
HIV-1
subtype B
non-pandemic
phylogeography
Latin America
dc.subject.en.pt_BR.fl_str_mv HIV-1
subtype B
non-pandemic
phylogeography
Latin America
description Não se trata da versão final do artigo. AIDS - http://www.lww.com/product/?0269-9370
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-11-24T16:55:27Z
dc.date.issued.fl_str_mv 2015
dc.date.available.fl_str_mv 2016-02-01T06:30:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CABELLO, Marina; JUNQUEIRA, Dennis Maletich; BELLO, Gonzalo. Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America. AIDS, v.29, n.4, p.483-492, Feb. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12316
dc.identifier.issn.none.fl_str_mv 1473-5571
identifier_str_mv CABELLO, Marina; JUNQUEIRA, Dennis Maletich; BELLO, Gonzalo. Dissemination of non-pandemic Caribbean HIV-1 subtype B clades in Latin America. AIDS, v.29, n.4, p.483-492, Feb. 2015.
1473-5571
url https://www.arca.fiocruz.br/handle/icict/12316
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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