Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe

Detalhes bibliográficos
Autor(a) principal: Cabello, Marina
Data de Publicação: 2016
Outros Autores: Romero, Hector, Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17988
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
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spelling Cabello, MarinaRomero, HectorBello, Gonzalo2017-03-09T15:10:01Z2017-03-09T15:10:01Z2016CABELLO, Marina; ROMERO, Hector; BELLO, Gonzalo. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, v.6:33971, Sept. 2016.2045-232https://www.arca.fiocruz.br/handle/icict/1798810.1038/srep33971engNature Publishing GroupHIV-1 subtipo BAmérica do NorteEuropaTransmissãoHIV-1 subtype BNorth AmericaEuropeTransmissionMultiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Universidad de la Republica. Facultad de Ciencias-CURE. Departamento de Ecologıa y Evolucion. Laboratorio de Organizacion y Evolucion del Genoma. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (BPANDEMIC) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (BCAR) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estimate the prevalence and to reconstruct the spatiotemporal dynamics of dissemination of HIV-1 BCAR strains in those regions. We find that BCAR strains were probably disseminated from the Caribbean into North America and Europe at multiple times since the early 1970s onwards. The BCAR strains reached the US, Canada and at least 16 different European countries, where they account for a very low fraction (<5%) of subtype B infections, with exception of the Czech Republic (7.7%). We also find evidence of the onward transmission of BCAR clades in the US, Canada, the Czech Republic, Germany, Italy, Spain and the UK, as well as short-distance spreading of BCAR lineages between neighboring European countries from Central and Western Europe, and long-distance dissemination between the US and Europe.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17988/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarina_cabello_etal_IOC_2016.pdfmarina_cabello_etal_IOC_2016.pdfapplication/pdf2193155https://www.arca.fiocruz.br/bitstream/icict/17988/2/marina_cabello_etal_IOC_2016.pdf6aba798fcda626c405aaf1782042bdc0MD52srep33971-s1.pdfsrep33971-s1.pdfMaterial 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dc.title.pt_BR.fl_str_mv Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
title Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
spellingShingle Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
Cabello, Marina
HIV-1 subtipo B
América do Norte
Europa
Transmissão
HIV-1 subtype B
North America
Europe
Transmission
title_short Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
title_full Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
title_fullStr Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
title_full_unstemmed Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
title_sort Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
author Cabello, Marina
author_facet Cabello, Marina
Romero, Hector
Bello, Gonzalo
author_role author
author2 Romero, Hector
Bello, Gonzalo
author2_role author
author
dc.contributor.author.fl_str_mv Cabello, Marina
Romero, Hector
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV-1 subtipo B
América do Norte
Europa
Transmissão
topic HIV-1 subtipo B
América do Norte
Europa
Transmissão
HIV-1 subtype B
North America
Europe
Transmission
dc.subject.en.pt_BR.fl_str_mv HIV-1 subtype B
North America
Europe
Transmission
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-09T15:10:01Z
dc.date.available.fl_str_mv 2017-03-09T15:10:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CABELLO, Marina; ROMERO, Hector; BELLO, Gonzalo. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, v.6:33971, Sept. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17988
dc.identifier.issn.pt_BR.fl_str_mv 2045-232
dc.identifier.doi.none.fl_str_mv 10.1038/srep33971
identifier_str_mv CABELLO, Marina; ROMERO, Hector; BELLO, Gonzalo. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, v.6:33971, Sept. 2016.
2045-232
10.1038/srep33971
url https://www.arca.fiocruz.br/handle/icict/17988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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