Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti

Detalhes bibliográficos
Autor(a) principal: Maior, Caetano Souto
Data de Publicação: 2018
Outros Autores: Sylvestre, Gabriel, Dias, Fernando Braga Stehling, Gomes, Gabriela, Freitas, Rafael Maciel de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31688
Resumo: Instituto Gulbenkian de Ciência Oeiras, Portugal
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spelling Maior, Caetano SoutoSylvestre, GabrielDias, Fernando Braga StehlingGomes, GabrielaFreitas, Rafael Maciel de2019-02-15T16:58:49Z2019-02-15T16:58:49Z2018MAIOR, Caetano Souto et al. Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti. PLoS Negl. Trop. Dis., v. 12, n. 3, p. 1-16, Mar. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/3168810.1371/journal.pntd.e00062291935-2735engPublic Library of ScienceWolbachiaEfeitosInfecçãovírus da dengue tipo 1Aedes aegyptiWolbachiatype 1 dengue virusAedes aegyptiInfectionEffectsModel-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegyptiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Gulbenkian de Ciência Oeiras, PortugalFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoáios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Rio de Janeiro, RJ, Brasil.Universidade do Porto. CIBIO-InBIo. Centro de Investigação em Biodiversidade e Recursos Genéticos. Porto, Portugal / Liverpool School of Tropical Medicine. Liverpool, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoáios. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, Brasil.Infection is a complex and dynamic process involving a population of invading microbes, the host and its responses, aimed at controlling the situation. Depending on the purpose and level of organization, infection at the organism level can be described by a process as simple as a coin toss, or as complex as a multi-factorial dynamic model; the former, for instance, may be adequate as a component of a population model, while the latter is necessary for a thorough description of the process beginning with a challenge with an infectious inoculum up to establishment or elimination of the pathogen. Experimental readouts in the laboratory are often static, snapshots of the process, assayed under some convenient experimental condition, and therefore cannot comprehensively describe the system. Different from the discrete treatment of infection in population models, or the descriptive summarized accounts of typical lab experiments, in this manuscript, infection is treated as a dynamic process dependent on the initial conditions of the infectious challenge, viral growth, and the host response along time. Here, experimental data is generated for multiple doses of type 1 dengue virus, and pathogen levels are recorded at different points in time for two populations of mosquitoes: either carrying endosymbiont bacteria Wolbachia or not. A dynamic microbe/ host-response mathematical model is used to describe pathogen growth in the face of a host response like the immune system, and to infer model parameters for the two populations of insects, revealing a slight—but potentially important—protection conferred by the symbiont.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31688/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgarbielsylvestre_rafaelfreitas_etal_IOC_2018.pdfgarbielsylvestre_rafaelfreitas_etal_IOC_2018.pdfapplication/pdf2015328https://www.arca.fiocruz.br/bitstream/icict/31688/2/garbielsylvestre_rafaelfreitas_etal_IOC_2018.pdfa74e01702c7ceaf75ebafae5fac5257cMD52TEXTgarbielsylvestre_rafaelfreitas_etal_IOC_2018.pdf.txtgarbielsylvestre_rafaelfreitas_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
title Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
spellingShingle Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
Maior, Caetano Souto
Wolbachia
Efeitos
Infecção
vírus da dengue tipo 1
Aedes aegypti
Wolbachia
type 1 dengue virus
Aedes aegypti
Infection
Effects
title_short Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
title_full Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
title_fullStr Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
title_full_unstemmed Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
title_sort Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti
author Maior, Caetano Souto
author_facet Maior, Caetano Souto
Sylvestre, Gabriel
Dias, Fernando Braga Stehling
Gomes, Gabriela
Freitas, Rafael Maciel de
author_role author
author2 Sylvestre, Gabriel
Dias, Fernando Braga Stehling
Gomes, Gabriela
Freitas, Rafael Maciel de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maior, Caetano Souto
Sylvestre, Gabriel
Dias, Fernando Braga Stehling
Gomes, Gabriela
Freitas, Rafael Maciel de
dc.subject.other.pt_BR.fl_str_mv Wolbachia
Efeitos
Infecção
vírus da dengue tipo 1
Aedes aegypti
topic Wolbachia
Efeitos
Infecção
vírus da dengue tipo 1
Aedes aegypti
Wolbachia
type 1 dengue virus
Aedes aegypti
Infection
Effects
dc.subject.en.pt_BR.fl_str_mv Wolbachia
type 1 dengue virus
Aedes aegypti
Infection
Effects
description Instituto Gulbenkian de Ciência Oeiras, Portugal
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-15T16:58:49Z
dc.date.available.fl_str_mv 2019-02-15T16:58:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAIOR, Caetano Souto et al. Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti. PLoS Negl. Trop. Dis., v. 12, n. 3, p. 1-16, Mar. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31688
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.e0006229
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv MAIOR, Caetano Souto et al. Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti. PLoS Negl. Trop. Dis., v. 12, n. 3, p. 1-16, Mar. 2018.
1935-2727
10.1371/journal.pntd.e0006229
1935-2735
url https://www.arca.fiocruz.br/handle/icict/31688
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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