Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52952 |
Resumo: | Universidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil. |
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Broto, G.E.Silva, P.R.B.Trigo, F.C.Victorino, V.J.Bonifácio, K.L.Pavanelli, W.R.Tomiotto-Pellissier, FernandaGarbim, M.R.Oliveira, S.T.Jumes, J.J.Panis, C.Barbosa, D. S.2022-05-27T13:07:17Z2022-05-27T13:07:17Z2021BROTO, G.E. et al. Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia. Current Research in Immunology, n. 2, p. 163–168, 2021.2590-2555https://www.arca.fiocruz.br/handle/icict/5295210.1016/j.crimmu.2021.09.002porElsevierImpact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil.Instituto do Cancer de Londrina, Londrina, PR, Brasil.Instituto Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.Universidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Programa de Pós-Graduação em Patologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Programa de Pós-Graduação em Patologia Experimental. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual do Oeste do Paraná. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil. / Universidade Estadual do Oeste do Paraná. Programa de Pós-graduação em Ciencias da Saude. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil. / Universidade Estadual do Oeste do Paraná. Programa de Pós-graduação em Ciencias da Saude. Francisco Beltrão, PR, Brasil. / Universidade Estadual de Londrina. Programa de Pós-Graduação em Patologia Experimental. Londrina, PR, Brasil.Universidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil.B-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxidative stress and cytokines in 17 B-ALL patients. Peripheral blood (PB) and bone marrow (BM) samples were collected and evaluated for the pro-oxidative status (nitric oxide products-NOx and hydroperoxides), antioxidants (sulfhydryl groups-SH and total radical-trapping antioxidant parameter-TRAP), and cytokines (TNF-α, IFN-γ), at diagnosis (D0) to and the end of the induction phase (D28). At D28, hydroperoxides were higher in PB, concomitant to TNF-α levels. INF-γ was increased in the BM at D28. Hydroperoxides were higher in patients presenting malignant cells in BM and/or PB after treatment, a condition named minimal residual disease (MRD) when compared to those without MRD at D28. These findings suggest that oxidative stress and cytokines vary across the B-ALL induction phase, and lipid peroxidation is a potential marker associated with MRD status.B-cell acute lymphocytic leukemiaLeukemia, Biphenotypic, AcuteCytokinesOxidative StressPrognosisMinimal residual diseaseLipid PeroxidesLeucemia Bifenotípica AgudaEstrés OxidativoPronósticoPeróxidos LipídicosLeucémie aigüe biphénotypiqueStress oxydatifPronosticMaladie résiduellePeroxydes lipidiquesLeucemia Aguda BifenotípicaCitocinasEstresse OxidativoPrognósticoNeoplasia ResidualPeróxidos Lipídicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/52952/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALBroto_GE-Impacto_induction.pdfBroto_GE-Impacto_induction.pdfapplication/pdf1190654https://www.arca.fiocruz.br/bitstream/icict/52952/2/Broto_GE-Impacto_induction.pdf7d84cfca7bd7ed0d18573931cc679172MD52icict/529522022-05-27 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| dc.title.pt_BR.fl_str_mv |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| spellingShingle |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia Broto, G.E. B-cell acute lymphocytic leukemia Leukemia, Biphenotypic, Acute Cytokines Oxidative Stress Prognosis Minimal residual disease Lipid Peroxides Leucemia Bifenotípica Aguda Estrés Oxidativo Pronóstico Peróxidos Lipídicos Leucémie aigüe biphénotypique Stress oxydatif Pronostic Maladie résiduelle Peroxydes lipidiques Leucemia Aguda Bifenotípica Citocinas Estresse Oxidativo Prognóstico Neoplasia Residual Peróxidos Lipídicos |
| title_short |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_full |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_fullStr |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_full_unstemmed |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| title_sort |
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia |
| author |
Broto, G.E. |
| author_facet |
Broto, G.E. Silva, P.R.B. Trigo, F.C. Victorino, V.J. Bonifácio, K.L. Pavanelli, W.R. Tomiotto-Pellissier, Fernanda Garbim, M.R. Oliveira, S.T. Jumes, J.J. Panis, C. Barbosa, D. S. |
| author_role |
author |
| author2 |
Silva, P.R.B. Trigo, F.C. Victorino, V.J. Bonifácio, K.L. Pavanelli, W.R. Tomiotto-Pellissier, Fernanda Garbim, M.R. Oliveira, S.T. Jumes, J.J. Panis, C. Barbosa, D. S. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Broto, G.E. Silva, P.R.B. Trigo, F.C. Victorino, V.J. Bonifácio, K.L. Pavanelli, W.R. Tomiotto-Pellissier, Fernanda Garbim, M.R. Oliveira, S.T. Jumes, J.J. Panis, C. Barbosa, D. S. |
| dc.subject.en.pt_BR.fl_str_mv |
B-cell acute lymphocytic leukemia Leukemia, Biphenotypic, Acute Cytokines Oxidative Stress Prognosis Minimal residual disease Lipid Peroxides |
| topic |
B-cell acute lymphocytic leukemia Leukemia, Biphenotypic, Acute Cytokines Oxidative Stress Prognosis Minimal residual disease Lipid Peroxides Leucemia Bifenotípica Aguda Estrés Oxidativo Pronóstico Peróxidos Lipídicos Leucémie aigüe biphénotypique Stress oxydatif Pronostic Maladie résiduelle Peroxydes lipidiques Leucemia Aguda Bifenotípica Citocinas Estresse Oxidativo Prognóstico Neoplasia Residual Peróxidos Lipídicos |
| dc.subject.es.pt_BR.fl_str_mv |
Leucemia Bifenotípica Aguda Estrés Oxidativo Pronóstico Peróxidos Lipídicos |
| dc.subject.fr.pt_BR.fl_str_mv |
Leucémie aigüe biphénotypique Stress oxydatif Pronostic Maladie résiduelle Peroxydes lipidiques |
| dc.subject.decs.pt_BR.fl_str_mv |
Leucemia Aguda Bifenotípica Citocinas Estresse Oxidativo Prognóstico Neoplasia Residual Peróxidos Lipídicos |
| description |
Universidade Estadual de Londrina. Programa de Pós-Graduação em Microbiologia. Londrina, PR, Brasil. |
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2021 |
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2021 |
| dc.date.accessioned.fl_str_mv |
2022-05-27T13:07:17Z |
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2022-05-27T13:07:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BROTO, G.E. et al. Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia. Current Research in Immunology, n. 2, p. 163–168, 2021. |
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https://www.arca.fiocruz.br/handle/icict/52952 |
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2590-2555 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.crimmu.2021.09.002 |
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BROTO, G.E. et al. Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia. Current Research in Immunology, n. 2, p. 163–168, 2021. 2590-2555 10.1016/j.crimmu.2021.09.002 |
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Elsevier |
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Elsevier |
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