Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts

Detalhes bibliográficos
Autor(a) principal: Sarno, Euzenir Nunes
Data de Publicação: 2012
Outros Autores: Duppre, Nádia Cristina, Sales, Anna Maria, Hacker, Mariana Andréa, Nery, José Augusto, Matos, Haroldo José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33275
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Sarno, Euzenir NunesDuppre, Nádia CristinaSales, Anna MariaHacker, Mariana AndréaNery, José AugustoMatos, Haroldo José2019-05-30T11:03:48Z2019-05-30T11:03:48Z2012SARNO, Euzenir Nunes et al. Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1054-1059, Dec. 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/3327510.1590/S0074-027620120008000151678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzHanseníaseEpidemiologiaVigilância de contatoLeprosyContact surveillanceEpidemiologyPGL-1Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contactsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Setor de Atendimento Médico Unificado. Belém, PA, Brasil.Contact surveillance is a valuable strategy for controlling leprosy. A dynamic cohort study of leprosy contacts was initiated in 1987 at Oswaldo Cruz Foundation. The objective of this work was to review the data on the major risk factors leading up to the infectious stage of the disease, estimate incidence rates of leprosy in the cohort and characterise the risk factors for the disease among the contacts under surveillance. The incidence rate of leprosy among contacts of leprosy patients was estimated at 0.01694 cases per person-year in the first five years of follow-up. The following factors were associated with acquiring the disease: (i) not receiving the BCG vaccine, (ii) a negative Mitsuda reaction and (iii) contact with a patient with a multibacillary clinical form of leprosy. The contacts of index patients who had high bacilloscopic index scores > 1 were at especially high risk of infection. The following factors were associated with infection, which was defined as a seropositive reaction for anti-phenolic glicolipid-1 IgM: (i) young age (< 20 years), (ii) a low measured Mitsuda reaction (< 5 mm) and (iii) contact with an index patient who had a high bacilloscopic index. BCG vaccination and re-vaccination were shown to be protective among household contacts. The main conclusions of this study indicate an urgent need for additional leprosy control strategies in areas with a high incidence of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33275/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEuzenirSarno_AnaMariaSales_etal_IOC_2012.pdfEuzenirSarno_AnaMariaSales_etal_IOC_2012.pdfapplication/pdf406092https://www.arca.fiocruz.br/bitstream/icict/33275/2/EuzenirSarno_AnaMariaSales_etal_IOC_2012.pdfdf65604a50a6297787df57c1e6c89f2fMD52TEXTEuzenirSarno_AnaMariaSales_etal_IOC_2012.pdf.txtEuzenirSarno_AnaMariaSales_etal_IOC_2012.pdf.txtExtracted texttext/plain37436https://www.arca.fiocruz.br/bitstream/icict/33275/3/EuzenirSarno_AnaMariaSales_etal_IOC_2012.pdf.txtb3faf06f28187a986b1be095bf4fff54MD53icict/332752022-06-24 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dc.title.pt_BR.fl_str_mv Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
title Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
spellingShingle Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
Sarno, Euzenir Nunes
Hanseníase
Epidemiologia
Vigilância de contato
Leprosy
Contact surveillance
Epidemiology
PGL-1
title_short Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
title_full Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
title_fullStr Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
title_full_unstemmed Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
title_sort Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts
author Sarno, Euzenir Nunes
author_facet Sarno, Euzenir Nunes
Duppre, Nádia Cristina
Sales, Anna Maria
Hacker, Mariana Andréa
Nery, José Augusto
Matos, Haroldo José
author_role author
author2 Duppre, Nádia Cristina
Sales, Anna Maria
Hacker, Mariana Andréa
Nery, José Augusto
Matos, Haroldo José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sarno, Euzenir Nunes
Duppre, Nádia Cristina
Sales, Anna Maria
Hacker, Mariana Andréa
Nery, José Augusto
Matos, Haroldo José
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Epidemiologia
Vigilância de contato
topic Hanseníase
Epidemiologia
Vigilância de contato
Leprosy
Contact surveillance
Epidemiology
PGL-1
dc.subject.en.pt_BR.fl_str_mv Leprosy
Contact surveillance
Epidemiology
PGL-1
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-05-30T11:03:48Z
dc.date.available.fl_str_mv 2019-05-30T11:03:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARNO, Euzenir Nunes et al. Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1054-1059, Dec. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33275
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762012000800015
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SARNO, Euzenir Nunes et al. Leprosy exposure, infection and disease: a 25-year surveillance study of leprosy patient contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1054-1059, Dec. 2012.
0074-0276
10.1590/S0074-02762012000800015
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33275
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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