Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies

Detalhes bibliográficos
Autor(a) principal: Ferrarini, Stela R.
Data de Publicação: 2008
Outros Autores: Graebin, Cedric S., Limberger, Jones, Canto, Romulo F. S., Dias, Daiane O., Rosa, Ricardo G. da, Madeira, Maria de Fátima, Eifler-Lima, Vera L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57444
Resumo: CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0).
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spelling Ferrarini, Stela R.Graebin, Cedric S.Limberger, JonesCanto, Romulo F. S.Dias, Daiane O.Rosa, Ricardo G. daMadeira, Maria de FátimaEifler-Lima, Vera L.2023-03-18T03:39:26Z2023-03-18T03:39:26Z2008FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/5744410.1590/S0074-027620080008000051678-8060CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0).Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Catálise por Metais de Transição. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Catálise por Metais de Transição. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Parasitologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.engFiocruz/IOCSynthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLimoneneβ-amino alcoholSynthesisLeishmaniasisLeishmania braziliensisNeglected diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Ferrarini_Stela_etal_INI_2008.pdfve_Ferrarini_Stela_etal_INI_2008.pdfapplication/pdf419329https://www.arca.fiocruz.br/bitstream/icict/57444/2/ve_Ferrarini_Stela_etal_INI_2008.pdf7509bd14d20d5a70582b5894ea1d6450MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57444/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/574442023-03-18 00:42:31.307oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-18T03:42:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
title Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
spellingShingle Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Ferrarini, Stela R.
Limonene
β-amino alcohol
Synthesis
Leishmaniasis
Leishmania braziliensis
Neglected diseases
title_short Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
title_full Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
title_fullStr Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
title_full_unstemmed Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
title_sort Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
author Ferrarini, Stela R.
author_facet Ferrarini, Stela R.
Graebin, Cedric S.
Limberger, Jones
Canto, Romulo F. S.
Dias, Daiane O.
Rosa, Ricardo G. da
Madeira, Maria de Fátima
Eifler-Lima, Vera L.
author_role author
author2 Graebin, Cedric S.
Limberger, Jones
Canto, Romulo F. S.
Dias, Daiane O.
Rosa, Ricardo G. da
Madeira, Maria de Fátima
Eifler-Lima, Vera L.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferrarini, Stela R.
Graebin, Cedric S.
Limberger, Jones
Canto, Romulo F. S.
Dias, Daiane O.
Rosa, Ricardo G. da
Madeira, Maria de Fátima
Eifler-Lima, Vera L.
dc.subject.en.en_US.fl_str_mv Limonene
β-amino alcohol
Synthesis
Leishmaniasis
Leishmania braziliensis
Neglected diseases
topic Limonene
β-amino alcohol
Synthesis
Leishmaniasis
Leishmania braziliensis
Neglected diseases
description CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0).
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2023-03-18T03:39:26Z
dc.date.available.fl_str_mv 2023-03-18T03:39:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57444
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762008000800005
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008.
0074-0276
10.1590/S0074-02762008000800005
1678-8060
url https://www.arca.fiocruz.br/handle/icict/57444
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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