Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer

Detalhes bibliográficos
Autor(a) principal: Galvão, Alexandre F. C
Data de Publicação: 2022
Outros Autores: Araújo, Morgana de S, Silva, Valdenizia R, Santos, Luciano de S, Dias, Rosane B, Rocha, Clarissa A. Gurgel, Soares, Milena B. P, Silva, Felipe M. A. da, Koolen, Hector H. F, Zengin, Gokhan, Costa, Emmanoel V, Bezerra, Daniel P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54902
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação Oswaldo Cruz (FIOCRUZ). Universidade Federal do Amazonas (UFAM).
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spelling Galvão, Alexandre F. CAraújo, Morgana de SSilva, Valdenizia RSantos, Luciano de SDias, Rosane BRocha, Clarissa A. GurgelSoares, Milena B. PSilva, Felipe M. A. daKoolen, Hector H. FZengin, GokhanCosta, Emmanoel VBezerra, Daniel P2022-09-27T17:53:29Z2022-09-27T17:53:29Z2022GALVÃO, Alexandre F. C. et al. Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer. Molecules, v. 27, p. 1-15, 2022.1420-3049https://www.arca.fiocruz.br/handle/icict/5490210.3390/ molecules27144407Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação Oswaldo Cruz (FIOCRUZ). Universidade Federal do Amazonas (UFAM).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC. Salvador, BA, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Grupo de Pesquisa em Metabolômica e Espectrometria de Massa. Manaus, AM, Brasil.Department of Biology. Science Faculty. Selcuk University. Konya, Turkey.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Guatteria olivacea R. E. Fries (synonym Guatteria punctata (Aubl.) R.A. Howard) is a tree of 10–27 m tall popularly known as “envira-bobó”, “envira-fofa”, “envireira”, “embira”, “embira-branca”, “embira-preta”, envira-branca”, and “envira-preta”, which can be found in the Brazilian Amazon biome. In this study, we evaluated the cytotoxic and antitumor effects of the essential oil (EO) obtained from the leaves of G. olivacea against liver cancer using HepG2 cells as a model. EO was obtained using a hydrodistillation Clevenger-type apparatus and was qualitatively and quantitatively characterized using GC–MS and GC–FID, respectively. The alamar blue assay was used to assess the cytotoxic potential of EO in a panel of human cancer cell lines and human non-cancerous cells. In HepG2 cells treated with EO, YO-PRO-1/propidium iodide staining, cell cycle distribution, and reactive oxygen species (ROS) were examined. In C.B-17 SCID mice with HepG2 cell xenografts, the efficacy of the EO (20 and 40 mg/kg) was tested in vivo. GC–MS and GC–FID analyses showed germacrene D (17.65%), 1-epi-cubenol (13.21%), caryophyllene oxide (12.03%), spathulenol (11.26%), (E)-caryophyllene (7.26%), bicyclogermacrene (5.87%), and δ-elemene (4.95%) as the major constituents of G. olivacea leaf EO. In vitro cytotoxicity of EO was observed, including anti-liver cancer action with an IC50 value of 30.82 μg/mL for HepG2 cells. In HepG2 cells, EO treatment increased apoptotic cells and DNA fragmentation, without changes in ROS levels. Furthermore, the EO inhibited tumor mass in vivo by 32.8–57.9%. These findings suggest that G. olivacea leaf EO has anti-liver cancer potential.engMDPILiver NeoplasmsGuatteria olivaceaÓleo essencialCâncer de fígadoAntitumoralGuatteria olivaceaEssential oilLiver cancerAntitumorÓleos VoláteisNeoplasias HepáticasAntitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54902/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGalvão, Alexandre F. C - Antitumor Effect of Guatteria olivacea R. E. Fr.pdfGalvão, Alexandre F. C - Antitumor Effect of Guatteria olivacea R. E. Fr.pdfapplication/pdf2212813https://www.arca.fiocruz.br/bitstream/icict/54902/2/Galv%c3%a3o%2c%20Alexandre%20%20F.%20C%20-%20Antitumor%20Effect%20of%20Guatteria%20olivacea%20R.%20E.%20Fr.pdfc37a65d2842137811c4de446773f4eafMD52icict/549022023-03-15 14:32:52.412oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
title Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
spellingShingle Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
Galvão, Alexandre F. C
Liver Neoplasms
Guatteria olivacea
Óleo essencial
Câncer de fígado
Antitumoral
Guatteria olivacea
Essential oil
Liver cancer
Antitumor
Óleos Voláteis
Neoplasias Hepáticas
title_short Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
title_full Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
title_fullStr Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
title_full_unstemmed Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
title_sort Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer
author Galvão, Alexandre F. C
author_facet Galvão, Alexandre F. C
Araújo, Morgana de S
Silva, Valdenizia R
Santos, Luciano de S
Dias, Rosane B
Rocha, Clarissa A. Gurgel
Soares, Milena B. P
Silva, Felipe M. A. da
Koolen, Hector H. F
Zengin, Gokhan
Costa, Emmanoel V
Bezerra, Daniel P
author_role author
author2 Araújo, Morgana de S
Silva, Valdenizia R
Santos, Luciano de S
Dias, Rosane B
Rocha, Clarissa A. Gurgel
Soares, Milena B. P
Silva, Felipe M. A. da
Koolen, Hector H. F
Zengin, Gokhan
Costa, Emmanoel V
Bezerra, Daniel P
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Galvão, Alexandre F. C
Araújo, Morgana de S
Silva, Valdenizia R
Santos, Luciano de S
Dias, Rosane B
Rocha, Clarissa A. Gurgel
Soares, Milena B. P
Silva, Felipe M. A. da
Koolen, Hector H. F
Zengin, Gokhan
Costa, Emmanoel V
Bezerra, Daniel P
dc.subject.mesh.en_US.fl_str_mv Liver Neoplasms
topic Liver Neoplasms
Guatteria olivacea
Óleo essencial
Câncer de fígado
Antitumoral
Guatteria olivacea
Essential oil
Liver cancer
Antitumor
Óleos Voláteis
Neoplasias Hepáticas
dc.subject.other.en_US.fl_str_mv Guatteria olivacea
Óleo essencial
Câncer de fígado
Antitumoral
dc.subject.en.en_US.fl_str_mv Guatteria olivacea
Essential oil
Liver cancer
Antitumor
dc.subject.decs.en_US.fl_str_mv Óleos Voláteis
Neoplasias Hepáticas
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação Oswaldo Cruz (FIOCRUZ). Universidade Federal do Amazonas (UFAM).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-27T17:53:29Z
dc.date.available.fl_str_mv 2022-09-27T17:53:29Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GALVÃO, Alexandre F. C. et al. Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer. Molecules, v. 27, p. 1-15, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54902
dc.identifier.issn.en_US.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/ molecules27144407
identifier_str_mv GALVÃO, Alexandre F. C. et al. Antitumor effect of guatteria olivacea R. E. Fr. (Annonaceae) leaf essential oil in liver cancer. Molecules, v. 27, p. 1-15, 2022.
1420-3049
10.3390/ molecules27144407
url https://www.arca.fiocruz.br/handle/icict/54902
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54902/1/license.txt
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