Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae)
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFPB |
Texto Completo: | https://repositorio.ufpb.br/jspui/handle/123456789/29345 |
Resumo: | About 80% of the population in developing countries depends on traditional or herbal medicine to treat and prevent diseases and, in Brazil, the use of medicinal plants is facilitated by the country's rich plant diversity. Species of the Annonaceae family have a high economic value, are used as raw material for cosmetics and perfumery and have a range of biological activities. About one of them, Guatteria olivacea found mainly in Amazonas, Acre and Pará, studies were published identifying alkaloids and terpenoids, with reports of in vitro antitumor activity. From this, this work sought to expand the knowledge about this plant, through a phytochemical study of its hexane extract. For this, the plant material was collected in the city of Manaus, Amazonas, Brazil and given to processes of inheritance, purification and analysis of chemical constituents. These procedures were performed by classical laboratory methods as well as by modern HPLC and NMR techniques. Therefore, from the hexane extract of the leaves of the plant, it was possible to isolate and characterize the chemical structures of two sesquiterpenes (alismoxide, oplodiol), a mixture of the sesquiterpene precarabrone with a phytolexin (4-bis(2-phenylpropan-2-yl) phenol) and a disquiterpene, isolated for the first time in Guatteria olivacea. Finally, the results obtained in the development of this work cultivated with the chemical knowledge of this and Annonaceae family species. |
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Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae)AnnonaceaeGuatteria olivaceaTerpenoidesSesquiterpenosCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAAbout 80% of the population in developing countries depends on traditional or herbal medicine to treat and prevent diseases and, in Brazil, the use of medicinal plants is facilitated by the country's rich plant diversity. Species of the Annonaceae family have a high economic value, are used as raw material for cosmetics and perfumery and have a range of biological activities. About one of them, Guatteria olivacea found mainly in Amazonas, Acre and Pará, studies were published identifying alkaloids and terpenoids, with reports of in vitro antitumor activity. From this, this work sought to expand the knowledge about this plant, through a phytochemical study of its hexane extract. For this, the plant material was collected in the city of Manaus, Amazonas, Brazil and given to processes of inheritance, purification and analysis of chemical constituents. These procedures were performed by classical laboratory methods as well as by modern HPLC and NMR techniques. Therefore, from the hexane extract of the leaves of the plant, it was possible to isolate and characterize the chemical structures of two sesquiterpenes (alismoxide, oplodiol), a mixture of the sesquiterpene precarabrone with a phytolexin (4-bis(2-phenylpropan-2-yl) phenol) and a disquiterpene, isolated for the first time in Guatteria olivacea. Finally, the results obtained in the development of this work cultivated with the chemical knowledge of this and Annonaceae family species.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESCerca de 80% da população de países em desenvolvimento depende da medicina tradicional ou fitoterápica para tratar e prevenir doenças e, no Brasil, o uso de plantas medicinais é facilitado pela rica diversidade vegetal do país. As espécies da família Annonaceae possuem alto valor econômico, são utilizadas como matéria-prima de alimentos e fármacos e possuem uma gama de atividades biológicas. Sobre uma destas, a Guatteria olivacea encontrada principalmente no Amazonas, Acre e Pará, foram publicados estudos com identificação de alcaloides e terpenoides, com relatos de atividade antitumoral in vitro. A partir disto, buscouse nesse trabalho ampliar o conhecimento sobre essa planta, mediante estudo fitoquímico de seu extrato hexânico. Para tal, o material vegetal foi coletado na cidade de Manaus, Amazonas, Brasil e submetido a processos de extração, purificação e análise dos constituintes químicos. Esses procedimentos foram realizados por métodos laboratoriais clássicos, assim como por técnicas modernas de CLAE e RMN. Portanto, a partir do extrato hexânico das folhas da planta, foi possível isolar e caracterizar as estruturas químicas de dois sesquiterpenos (alismóxido, oplodiol), uma mistura do sesquiterpeno precarabrona com uma fitoalexina (4-bis(2-fenilpropan-2-il)fenol) e um disesquiterpeno, isolados pela primeira vez em Guatteria olivacea. Por fim, os resultados obtidos no desenvolvimento deste trabalho contribuíram com o conhecimento químico desta espécie e da família Annonaceae.Universidade Federal da ParaíbaBrasilFarmacologiaPrograma de Pós-Graduação em Produtos Naturais e Sintéticos BioativosUFPBSantos, Sócrates Golzio dosLattes não recuperado em 22/01/2023Nascimento, Yuri Mangueira doLattes não recuperado em 22/01/2023Silva, Emille Wannick Reinaldo da2024-01-22T17:18:45Z2023-06-072024-01-22T17:18:45Z2023-04-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesishttps://repositorio.ufpb.br/jspui/handle/123456789/29345porAttribution-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nd/3.0/br/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFPBinstname:Universidade Federal da Paraíba (UFPB)instacron:UFPB2024-01-23T06:06:31Zoai:repositorio.ufpb.br:123456789/29345Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufpb.br/PUBhttp://tede.biblioteca.ufpb.br:8080/oai/requestdiretoria@ufpb.br|| diretoria@ufpb.bropendoar:2024-01-23T06:06:31Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)false |
dc.title.none.fl_str_mv |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
title |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
spellingShingle |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) Silva, Emille Wannick Reinaldo da Annonaceae Guatteria olivacea Terpenoides Sesquiterpenos CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
title_full |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
title_fullStr |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
title_full_unstemmed |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
title_sort |
Sesquiterpenos de Guatteria Olivacea R. E. FR. (Annonaceae) |
author |
Silva, Emille Wannick Reinaldo da |
author_facet |
Silva, Emille Wannick Reinaldo da |
author_role |
author |
dc.contributor.none.fl_str_mv |
Santos, Sócrates Golzio dos Lattes não recuperado em 22/01/2023 Nascimento, Yuri Mangueira do Lattes não recuperado em 22/01/2023 |
dc.contributor.author.fl_str_mv |
Silva, Emille Wannick Reinaldo da |
dc.subject.por.fl_str_mv |
Annonaceae Guatteria olivacea Terpenoides Sesquiterpenos CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
topic |
Annonaceae Guatteria olivacea Terpenoides Sesquiterpenos CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
About 80% of the population in developing countries depends on traditional or herbal medicine to treat and prevent diseases and, in Brazil, the use of medicinal plants is facilitated by the country's rich plant diversity. Species of the Annonaceae family have a high economic value, are used as raw material for cosmetics and perfumery and have a range of biological activities. About one of them, Guatteria olivacea found mainly in Amazonas, Acre and Pará, studies were published identifying alkaloids and terpenoids, with reports of in vitro antitumor activity. From this, this work sought to expand the knowledge about this plant, through a phytochemical study of its hexane extract. For this, the plant material was collected in the city of Manaus, Amazonas, Brazil and given to processes of inheritance, purification and analysis of chemical constituents. These procedures were performed by classical laboratory methods as well as by modern HPLC and NMR techniques. Therefore, from the hexane extract of the leaves of the plant, it was possible to isolate and characterize the chemical structures of two sesquiterpenes (alismoxide, oplodiol), a mixture of the sesquiterpene precarabrone with a phytolexin (4-bis(2-phenylpropan-2-yl) phenol) and a disquiterpene, isolated for the first time in Guatteria olivacea. Finally, the results obtained in the development of this work cultivated with the chemical knowledge of this and Annonaceae family species. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-07 2023-04-05 2024-01-22T17:18:45Z 2024-01-22T17:18:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufpb.br/jspui/handle/123456789/29345 |
url |
https://repositorio.ufpb.br/jspui/handle/123456789/29345 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nd/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal da Paraíba Brasil Farmacologia Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos UFPB |
publisher.none.fl_str_mv |
Universidade Federal da Paraíba Brasil Farmacologia Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos UFPB |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFPB instname:Universidade Federal da Paraíba (UFPB) instacron:UFPB |
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Universidade Federal da Paraíba (UFPB) |
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UFPB |
institution |
UFPB |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFPB |
collection |
Biblioteca Digital de Teses e Dissertações da UFPB |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB) |
repository.mail.fl_str_mv |
diretoria@ufpb.br|| diretoria@ufpb.br |
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1801843015374864384 |