Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage

Detalhes bibliográficos
Autor(a) principal: Tekiel, Valeria
Data de Publicação: 2005
Outros Autores: Oliveira, Guilherme Corrêa de, Oliveira, Rodrigo Corrêa de, Sanchez, Daniel, Cappa, Stella Maris Gonzalez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6812
Resumo: Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiologıa, Parasitologıa e Inmunologıa. Buenos Aires, Argentina/Universidad Nacional de General San Martın—CONICET. Instituto de Investigaciones Biotecnologicas. Buenos Aires, Argentina
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spelling Tekiel, ValeriaOliveira, Guilherme Corrêa deOliveira, Rodrigo Corrêa deSanchez, DanielCappa, Stella Maris Gonzalez2013-08-21T16:58:25Z2013-08-21T16:58:25Z2005TEKIEL, Valeria et al. Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage. Acta Trop., v. 94, n. 1, p. 15-24, 2005.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/6812engElsevierChagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damageinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiologıa, Parasitologıa e Inmunologıa. Buenos Aires, Argentina/Universidad Nacional de General San Martın—CONICET. Instituto de Investigaciones Biotecnologicas. Buenos Aires, ArgentinaFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, BrazilUniversidad Nacional de General San Martın—CONICET. Instituto de Investigaciones Biotecnologicas. Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiologıa, Parasitologıa e Inmunologıa. Buenos Aires, ArgentinaUsing the same mouse strain and two Trypanosoma cruzisub-populations (CA-I and RA) it is possible to induce pathology in different target tissues: skeletal muscle (CA-I) or sciatic nerve and spinal cord (RA). On the other hand, T cells are directly involved in tissue injury in a strain-dependent way, resembling the abnormalities of chronic Chagas’ disease. In the present work, we examined the TCRBV repertoire and the CDR3 sequence polymorphism of T cells infiltrating spinal cord, sciatic nerve and skeletal muscle in chronically infected mice. The TCRBV9 segment was systematically over-represented in the target tissues for eachT. cruzistrain: sciatic nerve and spinal cord in RA and skeletal muscle in CA-I-infected mice. The analysis of CDR3 sequence polymorphism in the same tissues showed a high proportion of identical TCRBV9 clones in RA-infected mice: 66.6% of the TCRBV9 clones found in sciatic nerve and spinal cord expressed one out of four major CDR3 rearrangements. Sequence identity was shared among clones from sciatic nerve and spinal cord, tissues that are also damaged by passive transfer of CD8 + TL. Those observations are consistent with an antigen driven T-cell expansion sequestered at the inflammation site and demonstrate – for the first time – the presence of an oligoclonal repertoire in the antigen recognition site of over-represented T cells in nervous system tissues in chronic Chagas’ disease.Trypanosoma cruziT-cell receptorCDR3 polymorphismClonal expansionNervous systeminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL85. Chagas’ disease TCRBV9 over-representation and sequence.pdf85. Chagas’ disease TCRBV9 over-representation and sequence.pdfapplication/pdf269960https://www.arca.fiocruz.br/bitstream/icict/6812/1/85.%20Chagas%e2%80%99%20disease%20TCRBV9%20over-representation%20and%20sequence.pdf26bf1085a6d6643388a483614e3f611fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6812/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT85. Chagas’ disease TCRBV9 over-representation and sequence.pdf.txt85. Chagas’ disease TCRBV9 over-representation and sequence.pdf.txtExtracted texttext/plain37912https://www.arca.fiocruz.br/bitstream/icict/6812/5/85.%20Chagas%e2%80%99%20disease%20TCRBV9%20over-representation%20and%20sequence.pdf.txt67cd5b01cad25aa7c9cc99f8bc6903d3MD55THUMBNAIL85. Chagas’ disease TCRBV9 over-representation and sequence.pdf.jpg85. Chagas’ disease TCRBV9 over-representation and sequence.pdf.jpgGenerated Thumbnailimage/jpeg1161https://www.arca.fiocruz.br/bitstream/icict/6812/4/85.%20Chagas%e2%80%99%20disease%20TCRBV9%20over-representation%20and%20sequence.pdf.jpg43810212bb05ddcc0ca04deed61a5e33MD54icict/68122018-05-21 16:47:41.288oai:www.arca.fiocruz.br:icict/6812Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-21T19:47:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
title Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
spellingShingle Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
Tekiel, Valeria
Trypanosoma cruzi
T-cell receptor
CDR3 polymorphism
Clonal expansion
Nervous system
title_short Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
title_full Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
title_fullStr Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
title_full_unstemmed Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
title_sort Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage
author Tekiel, Valeria
author_facet Tekiel, Valeria
Oliveira, Guilherme Corrêa de
Oliveira, Rodrigo Corrêa de
Sanchez, Daniel
Cappa, Stella Maris Gonzalez
author_role author
author2 Oliveira, Guilherme Corrêa de
Oliveira, Rodrigo Corrêa de
Sanchez, Daniel
Cappa, Stella Maris Gonzalez
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tekiel, Valeria
Oliveira, Guilherme Corrêa de
Oliveira, Rodrigo Corrêa de
Sanchez, Daniel
Cappa, Stella Maris Gonzalez
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
T-cell receptor
CDR3 polymorphism
Clonal expansion
Nervous system
topic Trypanosoma cruzi
T-cell receptor
CDR3 polymorphism
Clonal expansion
Nervous system
description Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiologıa, Parasitologıa e Inmunologıa. Buenos Aires, Argentina/Universidad Nacional de General San Martın—CONICET. Instituto de Investigaciones Biotecnologicas. Buenos Aires, Argentina
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2013-08-21T16:58:25Z
dc.date.available.fl_str_mv 2013-08-21T16:58:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TEKIEL, Valeria et al. Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage. Acta Trop., v. 94, n. 1, p. 15-24, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6812
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv TEKIEL, Valeria et al. Chagas' disease: TCRBV9 over-representation and sequence oligoclonality in the fine specificity of T lymphocytes in target tissues of damage. Acta Trop., v. 94, n. 1, p. 15-24, 2005.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/6812
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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collection Repositório Institucional da FIOCRUZ (ARCA)
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