ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells

Detalhes bibliográficos
Autor(a) principal: Golbert, Daiane Cristina Ferreira
Data de Publicação: 2013
Outros Autores: Santana, Eliane Correa de, Alves, Marcelo Ribeiro, Vasconcelos, Ana Tereza Ribeiro de, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33844
Resumo: From 8th International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2012). Campinas, Brazil. 14-17 October 2012.
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spelling Golbert, Daiane Cristina FerreiraSantana, Eliane Correa deAlves, Marcelo RibeiroVasconcelos, Ana Tereza Ribeiro deSavino, Wilson2019-07-04T15:51:58Z2019-07-04T15:51:58Z2013GOLBERT, Daiana Cristina Ferreira et al. ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells. BMC Genomics, v. 14, Suppl. 6, n. 53, p.1-9, 2013.1471-2164https://www.arca.fiocruz.br/handle/icict/3384410.1186/1471-2164-14-S6-S3From 8th International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2012). Campinas, Brazil. 14-17 October 2012.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Laboratório Nacional de Computação Científica. Laboratório de Bioinformática. Petrópolis, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Laboratório Nacional de Computação Científica. Laboratório de Bioinformática. Petrópolis, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.The thymic epithelium is the major microenvironmental component of the thymus, the primary lymphoid organ responsible for the generation of T lymphocytes. Thymic epithelial cells (TEC) control intrathymic T cell differentiation by means of distinct types of interactions. TEC constitutively produce chemokines and extracellular matrix ligands (such as laminin and fibronectin) and express corresponding receptors, which allow thymocytes to migrate in a very ordered fashion. We previously showed that laminin mediates TEC/thymocyte interactions in both mice and humans. More recently, we used RNAi technology to knock-down the ITGA5 gene (which encodes CD49e, the integrin a-chain subunit of the fibronectin receptor VLA-5) in cultured human TEC. Using a similar strategy, herein we nocked-down the ITGA6 gene, which encodes CD49f, the a-chain of two integrin-type laminin receptors, namely VLA-6 (a6b1) and a6b4.engBioMed CentralGene ITGA 6Células epitelias humanasMigração celularRNATimoITGA6 geneRNACell migrationHuman thymic epithelial cellsThymusITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
title ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
spellingShingle ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
Golbert, Daiane Cristina Ferreira
Gene ITGA 6
Células epitelias humanas
Migração celular
RNA
Timo
ITGA6 gene
RNA
Cell migration
Human thymic epithelial cells
Thymus
title_short ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
title_full ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
title_fullStr ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
title_full_unstemmed ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
title_sort ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
author Golbert, Daiane Cristina Ferreira
author_facet Golbert, Daiane Cristina Ferreira
Santana, Eliane Correa de
Alves, Marcelo Ribeiro
Vasconcelos, Ana Tereza Ribeiro de
Savino, Wilson
author_role author
author2 Santana, Eliane Correa de
Alves, Marcelo Ribeiro
Vasconcelos, Ana Tereza Ribeiro de
Savino, Wilson
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Golbert, Daiane Cristina Ferreira
Santana, Eliane Correa de
Alves, Marcelo Ribeiro
Vasconcelos, Ana Tereza Ribeiro de
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Gene ITGA 6
Células epitelias humanas
Migração celular
RNA
Timo
topic Gene ITGA 6
Células epitelias humanas
Migração celular
RNA
Timo
ITGA6 gene
RNA
Cell migration
Human thymic epithelial cells
Thymus
dc.subject.en.pt_BR.fl_str_mv ITGA6 gene
RNA
Cell migration
Human thymic epithelial cells
Thymus
description From 8th International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2012). Campinas, Brazil. 14-17 October 2012.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2019-07-04T15:51:58Z
dc.date.available.fl_str_mv 2019-07-04T15:51:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOLBERT, Daiana Cristina Ferreira et al. ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells. BMC Genomics, v. 14, Suppl. 6, n. 53, p.1-9, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33844
dc.identifier.issn.pt_BR.fl_str_mv 1471-2164
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1471-2164-14-S6-S3
identifier_str_mv GOLBERT, Daiana Cristina Ferreira et al. ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells. BMC Genomics, v. 14, Suppl. 6, n. 53, p.1-9, 2013.
1471-2164
10.1186/1471-2164-14-S6-S3
url https://www.arca.fiocruz.br/handle/icict/33844
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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