Modulation of virulence factors during Trypanosoma cruzi differentiation

Detalhes bibliográficos
Autor(a) principal: Oliveira, Camila
Data de Publicação: 2023
Outros Autores: Holetz, Fabíola Barbieri, Alves, Lysangela Ronalte, Ávila, Andréa Rodrigues
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: doi.org/10.3390/ pathogens12010032
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57380
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Centre de Recherche CERVO, Université Laval. Québec City, Canada.
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spelling Oliveira, CamilaHoletz, Fabíola BarbieriAlves, Lysangela RonalteÁvila, Andréa Rodrigues2023-03-15T16:12:14Z2023-03-15T16:12:14Z2023OLIVEIRA, Camila et al. Modulation of virulence factors during Trypanosoma cruzi differentiation. Pathogens, v. 12, n. 32, p. 1–14, 2023.2076-0817https://www.arca.fiocruz.br/handle/icict/57380doi.org/10.3390/ pathogens12010032porMDPIProteínas de SuperfícieInfecção por Trypanosoma cruziGene Expression RegulationMembrane ProteinsChagas DiseaseCell DifferentiationRegulación de la Expresión GénicaProteínas de la MembranaEnfermedad de ChagasDiferenciación CelularRégulation de l'expression des gènesProtéines membranairesMaladie de ChagasDifférenciation cellulaireRegulação da Expressão GênicaProteínas de MembranaDoença de ChagasDiferenciação CelularModulation of virulence factors during Trypanosoma cruzi differentiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Centre de Recherche CERVO, Université Laval. Québec City, Canada.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Research Center in Infectious Diseases. Division of Infectious Disease and Immunity CHU de Quebec Research Center, University Laval, Québec City, Canada.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. This protozoan developed several mechanisms to infect, propagate, and survive in different hosts. The specific expression of proteins is responsible for morphological and metabolic changes in different parasite stages along the parasite life cycle. The virulence strategies at the cellular and molecular levels consist of molecules responsible for mediating resistance mechanisms to oxidative damage, cellular invasion, and immune evasion, performed mainly by surface proteins. Since parasite surface coat remodeling is crucial to invasion and infectivity, surface proteins are essential virulence elements. Understanding the factors involved in these processes improves the knowledge of parasite pathogenesis. Genome sequencing has opened the door to high-throughput technologies, allowing us to obtain a deeper understanding of gene reprogramming along the parasite life cycle and identify critical molecules for survival. This review therefore focuses on proteins regulated during differentiation into infective forms considered virulence factors and addresses the current known mechanisms acting in the modulation of gene expression, emphasizing mRNA signals, regulatory factors, and protein complexes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57380/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpathogens-12-00032.pdfpathogens-12-00032.pdfapplication/pdf367871https://www.arca.fiocruz.br/bitstream/icict/57380/2/pathogens-12-00032.pdfe0bac8dc36b74c3d2089984393c081cbMD52icict/573802023-03-15 13:12:16.201oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T16:12:16Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Modulation of virulence factors during Trypanosoma cruzi differentiation
title Modulation of virulence factors during Trypanosoma cruzi differentiation
spellingShingle Modulation of virulence factors during Trypanosoma cruzi differentiation
Oliveira, Camila
Proteínas de Superfície
Infecção por Trypanosoma cruzi
Gene Expression Regulation
Membrane Proteins
Chagas Disease
Cell Differentiation
Regulación de la Expresión Génica
Proteínas de la Membrana
Enfermedad de Chagas
Diferenciación Celular
Régulation de l'expression des gènes
Protéines membranaires
Maladie de Chagas
Différenciation cellulaire
Regulação da Expressão Gênica
Proteínas de Membrana
Doença de Chagas
Diferenciação Celular
title_short Modulation of virulence factors during Trypanosoma cruzi differentiation
title_full Modulation of virulence factors during Trypanosoma cruzi differentiation
title_fullStr Modulation of virulence factors during Trypanosoma cruzi differentiation
title_full_unstemmed Modulation of virulence factors during Trypanosoma cruzi differentiation
title_sort Modulation of virulence factors during Trypanosoma cruzi differentiation
author Oliveira, Camila
author_facet Oliveira, Camila
Holetz, Fabíola Barbieri
Alves, Lysangela Ronalte
Ávila, Andréa Rodrigues
author_role author
author2 Holetz, Fabíola Barbieri
Alves, Lysangela Ronalte
Ávila, Andréa Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Camila
Holetz, Fabíola Barbieri
Alves, Lysangela Ronalte
Ávila, Andréa Rodrigues
dc.subject.other.en_US.fl_str_mv Proteínas de Superfície
Infecção por Trypanosoma cruzi
topic Proteínas de Superfície
Infecção por Trypanosoma cruzi
Gene Expression Regulation
Membrane Proteins
Chagas Disease
Cell Differentiation
Regulación de la Expresión Génica
Proteínas de la Membrana
Enfermedad de Chagas
Diferenciación Celular
Régulation de l'expression des gènes
Protéines membranaires
Maladie de Chagas
Différenciation cellulaire
Regulação da Expressão Gênica
Proteínas de Membrana
Doença de Chagas
Diferenciação Celular
dc.subject.en.en_US.fl_str_mv Gene Expression Regulation
Membrane Proteins
Chagas Disease
Cell Differentiation
dc.subject.es.en_US.fl_str_mv Regulación de la Expresión Génica
Proteínas de la Membrana
Enfermedad de Chagas
Diferenciación Celular
dc.subject.fr.en_US.fl_str_mv Régulation de l'expression des gènes
Protéines membranaires
Maladie de Chagas
Différenciation cellulaire
dc.subject.decs.en_US.fl_str_mv Regulação da Expressão Gênica
Proteínas de Membrana
Doença de Chagas
Diferenciação Celular
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Centre de Recherche CERVO, Université Laval. Québec City, Canada.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-15T16:12:14Z
dc.date.available.fl_str_mv 2023-03-15T16:12:14Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Camila et al. Modulation of virulence factors during Trypanosoma cruzi differentiation. Pathogens, v. 12, n. 32, p. 1–14, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57380
dc.identifier.issn.en_US.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv doi.org/10.3390/ pathogens12010032
identifier_str_mv OLIVEIRA, Camila et al. Modulation of virulence factors during Trypanosoma cruzi differentiation. Pathogens, v. 12, n. 32, p. 1–14, 2023.
2076-0817
doi.org/10.3390/ pathogens12010032
url https://www.arca.fiocruz.br/handle/icict/57380
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57380/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57380/2/pathogens-12-00032.pdf
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