Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets

Detalhes bibliográficos
Autor(a) principal: Reis, Patricia Alves
Data de Publicação: 2022
Outros Autores: Faria Neto, Hugo Caire Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53625
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil.
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spelling Reis, Patricia AlvesFaria Neto, Hugo Caire Castro2022-07-04T12:28:17Z2022-07-04T12:28:17Z2022REIS, Patrícia Alves; FARIA NETO, Hugo Caire Castro. Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets. Frontiers in Neuroscience, v. 15, Article 742158, p. 1 - 12, Feb. 2022.1662-4548https://www.arca.fiocruz.br/handle/icict/5362510.3389/fnins.2021.742158engFrontiers MediaDoenças infecciosasNeuroinflamaçãoEstresse oxidativoDeficiência cognitivaTerapia aditivaInfectious diseasesNeuroinflammationOxidative stressCognitive impairmentAdditive therapySystemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.In response to pathogens or damage signs, the immune system is activated in order to eliminate the noxious stimuli. The inflammatory response to infectious diseases induces systemic events, including cytokine storm phenomenon, vascular dysfunction, and coagulopathy, that can lead to multiple-organ dysfunction. The central nervous system (CNS) is one of the major organs affected, and symptoms such as sickness behavior (depression and fever, among others), or even delirium, can be observed due to activation of endothelial and glial cells, leading to neuroinflammation. Several reports have been shown that, due to CNS alterations caused by neuroinflammation, some sequels can be developed in special cognitive decline. There is still no any treatment to avoid cognitive impairment, especially those developed due to systemic infectious diseases, but preclinical and clinical trials have pointed out controlling neuroinflammatory events to avoid the development of this sequel. In this minireview, we point to the possible mechanisms that triggers long-term cognitive decline, proposing the acute neuroinflammatory events as a potential therapeutical target to treat this sequel that has been associated to several infectious diseases, such as malaria, sepsis, and, more recently, the new SARS-Cov2 infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53625/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaReis_HUgoCFariaNeto_etal_IOC_2022.pdfPatriciaReis_HUgoCFariaNeto_etal_IOC_2022.pdfapplication/pdf696322https://www.arca.fiocruz.br/bitstream/icict/53625/2/PatriciaReis_HUgoCFariaNeto_etal_IOC_2022.pdf02a1c96120055cc1d8161d9a27661fe7MD52icict/536252022-07-04 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dc.title.pt_BR.fl_str_mv Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
title Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
spellingShingle Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
Reis, Patricia Alves
Doenças infecciosas
Neuroinflamação
Estresse oxidativo
Deficiência cognitiva
Terapia aditiva
Infectious diseases
Neuroinflammation
Oxidative stress
Cognitive impairment
Additive therapy
title_short Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
title_full Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
title_fullStr Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
title_full_unstemmed Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
title_sort Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
author Reis, Patricia Alves
author_facet Reis, Patricia Alves
Faria Neto, Hugo Caire Castro
author_role author
author2 Faria Neto, Hugo Caire Castro
author2_role author
dc.contributor.author.fl_str_mv Reis, Patricia Alves
Faria Neto, Hugo Caire Castro
dc.subject.other.pt_BR.fl_str_mv Doenças infecciosas
Neuroinflamação
Estresse oxidativo
Deficiência cognitiva
Terapia aditiva
topic Doenças infecciosas
Neuroinflamação
Estresse oxidativo
Deficiência cognitiva
Terapia aditiva
Infectious diseases
Neuroinflammation
Oxidative stress
Cognitive impairment
Additive therapy
dc.subject.en.pt_BR.fl_str_mv Infectious diseases
Neuroinflammation
Oxidative stress
Cognitive impairment
Additive therapy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-04T12:28:17Z
dc.date.available.fl_str_mv 2022-07-04T12:28:17Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Patrícia Alves; FARIA NETO, Hugo Caire Castro. Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets. Frontiers in Neuroscience, v. 15, Article 742158, p. 1 - 12, Feb. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53625
dc.identifier.issn.pt_BR.fl_str_mv 1662-4548
dc.identifier.doi.none.fl_str_mv 10.3389/fnins.2021.742158
identifier_str_mv REIS, Patrícia Alves; FARIA NETO, Hugo Caire Castro. Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets. Frontiers in Neuroscience, v. 15, Article 742158, p. 1 - 12, Feb. 2022.
1662-4548
10.3389/fnins.2021.742158
url https://www.arca.fiocruz.br/handle/icict/53625
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53625/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53625/2/PatriciaReis_HUgoCFariaNeto_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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