Oxidative stress and neuroinflammation in neurodegenerative diseases: possible neuroprotective effect of agathisflavone

• Autor(a) principal: Oliveira Júnior, Gilson Pereira Britto de
• Data de Publicação: 2020
• Outros Autores: Pimenta, Rodolfo Macedo Cruz, Oliveira, Walker Nonato Ferreira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11061
• topic: Agathisflavone; Antioxidant; Neuroprotector; Neuroinflammation; Oxidative stress.; Agatisflavona; Antioxidante; Neuroprotector; Neuroinflamación; Estrés oxidativo.; Agatisflavona; Antioxidante; Neuroprotetor; Neuroinflamação; Estresse oxidativo.

Oxidative stress and neuroinflammation are gaining prominence as essential contributing factors in neurodegenerative diseases. In this context, the flavonoids have powerful anti-inflammatory and antioxidant properties that can serve as therapy in these diseases. A representative of this group is the biflavonoid, agathisflavone, which in several studies has demonstrated biological actions that deserve attention for the pharmaceutical industry in the therapy of neurodegenerative diseases. Through a systematic review of the literature, we analyzed the scientific/experimental publications published between 2011 and 2020 in the databases of PubMed and ScienceDirect, with the aim of systematizing the important findings on agathisflavone that may contribute to its therapeutic approach. Data were extracted from 11 studies that documented important therapeutic actions that can help in the treatment of neurodegenerative diseases, such as anti-inflammatory activity, immunomodulator, neurogenesis induction, free radical neutralization, neuroprotection and neuronal death reduction. From the data obtained, it was observed that agathisflavone has promising characteristics to act as an adjuvant neuroprotector for the treatment of neurodegenerative diseases; however, it is necessary more in-depth and specific studies, so that its therapeutic value is evidenced.