Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19675 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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Prevatto, Jessika P.Torres, Rafael C.Diaz, Bruno L.Silva, Patrícia M. R. eMartins, Marco A.Carvalho, Vinicius F.2017-06-29T15:56:22Z2017-06-29T15:56:22Z2017PREVATTO, Jessika P. et al. Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary. Oxidative Medicine and Cellular Longevity, Vol. 2017, Article ID 4156361, 10p, 20171942-0900https://www.arca.fiocruz.br/handle/icict/1967510.1155/2017/41563611942-0994engHindawi Publishing CorporationTratamento com antioxidantesGlândulas SuprarrenaisSistema Hipófise-SuprarrenalReceptores de GlucocorticoidesGlucocorticoid ReceptorsAntioxidant TreatmentHPAHyperactivationPituitary-Adrenal SystemAntioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitaryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. .Glucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproduction of reactive oxygen species (ROS); however, nothing is known about the effects of ROS on the functionality of the HPA axis during homeostasis. This study analyzed the putative impact of antioxidants on the HPA axis activity and GC-mediated negative feedback upon the HPA cascade. Male Wistar rats were orally treated with N-acetylcysteine (NAC) or vitamin E for 18 consecutive days. NAC-treated rats were then subjected to a daily treatment with dexamethasone, which covered the last 5 days of the antioxidant therapy. We found that NAC and vitamin E induced an increase in plasma corticosterone levels. NAC intensified MC2R and StAR expressions in the adrenal and reduced GR and MR expressions in the pituitary. NAC also prevented the dexamethasone-induced reduction in plasma corticosterone levels. Furthermore, NAC decreased HO-1 and Nrf2 expression in the pituitary. These findings show that antioxidants induce hyperactivity of the HPA axis via upregulation of MC2R expression in the adrenal and downregulation of GR and MR in the pituitary.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19675/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjessika_prevatto_etal_IOC_2017.pdfjessika_prevatto_etal_IOC_2017.pdfapplication/pdf6433963https://www.arca.fiocruz.br/bitstream/icict/19675/2/jessika_prevatto_etal_IOC_2017.pdfdb1220d6ab514f6415803c62d8fa5040MD52TEXTjessika_prevatto_etal_IOC_2017.pdf.txtjessika_prevatto_etal_IOC_2017.pdf.txtExtracted texttext/plain46886https://www.arca.fiocruz.br/bitstream/icict/19675/3/jessika_prevatto_etal_IOC_2017.pdf.txt6093019d86efc64ec15edf50154338d8MD53icict/196752023-09-05 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dc.title.pt_BR.fl_str_mv |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
title |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
spellingShingle |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary Prevatto, Jessika P. Tratamento com antioxidantes Glândulas Suprarrenais Sistema Hipófise-Suprarrenal Receptores de Glucocorticoides Glucocorticoid Receptors Antioxidant Treatment HPA Hyperactivation Pituitary-Adrenal System |
title_short |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
title_full |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
title_fullStr |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
title_full_unstemmed |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
title_sort |
Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary |
author |
Prevatto, Jessika P. |
author_facet |
Prevatto, Jessika P. Torres, Rafael C. Diaz, Bruno L. Silva, Patrícia M. R. e Martins, Marco A. Carvalho, Vinicius F. |
author_role |
author |
author2 |
Torres, Rafael C. Diaz, Bruno L. Silva, Patrícia M. R. e Martins, Marco A. Carvalho, Vinicius F. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Prevatto, Jessika P. Torres, Rafael C. Diaz, Bruno L. Silva, Patrícia M. R. e Martins, Marco A. Carvalho, Vinicius F. |
dc.subject.other.pt_BR.fl_str_mv |
Tratamento com antioxidantes Glândulas Suprarrenais Sistema Hipófise-Suprarrenal Receptores de Glucocorticoides |
topic |
Tratamento com antioxidantes Glândulas Suprarrenais Sistema Hipófise-Suprarrenal Receptores de Glucocorticoides Glucocorticoid Receptors Antioxidant Treatment HPA Hyperactivation Pituitary-Adrenal System |
dc.subject.en.pt_BR.fl_str_mv |
Glucocorticoid Receptors Antioxidant Treatment HPA Hyperactivation Pituitary-Adrenal System |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-06-29T15:56:22Z |
dc.date.available.fl_str_mv |
2017-06-29T15:56:22Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PREVATTO, Jessika P. et al. Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary. Oxidative Medicine and Cellular Longevity, Vol. 2017, Article ID 4156361, 10p, 2017 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19675 |
dc.identifier.issn.pt_BR.fl_str_mv |
1942-0900 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2017/4156361 |
dc.identifier.eissn.none.fl_str_mv |
1942-0994 |
identifier_str_mv |
PREVATTO, Jessika P. et al. Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary. Oxidative Medicine and Cellular Longevity, Vol. 2017, Article ID 4156361, 10p, 2017 1942-0900 10.1155/2017/4156361 1942-0994 |
url |
https://www.arca.fiocruz.br/handle/icict/19675 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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