The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.

Detalhes bibliográficos
Autor(a) principal: Santos, Claire da Silva
Data de Publicação: 2014
Outros Autores: Brodskyn, Claudia Ida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8819
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
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spelling Santos, Claire da SilvaBrodskyn, Claudia Ida2014-11-12T19:35:15Z2014-11-12T19:35:15Z2014SANTOS, C. S.; BRODSKYN, C. I. The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. Frontiers Public Health, v. 2, p.165, 2014.2296-2565https://www.arca.fiocruz.br/handle/icict/881910.3389/fpubh.2014.00165engFrontiersThe Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilLeishmaniasis, caused by infection with parasites of the Leishmania genus, affects millions of individuals worldwide.This disease displays distinct clinical manifestations ranging from self-healing skin lesions to severe tissue damage. The control of Leishmania infection is dependent on cellular immune mechanisms, and evidence has shown that CD4 and CD8T lymphocytes play different roles in the outcome of leishmaniasis. Although the presence of CD4T cells is important for controlling parasite growth, the results in the literature suggest that the inflammatory response elicited by these cells could contribute to the pathogenesis of lesions. However, recent studies on CD8 T lymphocytes show that these cells are mainly involved in tissue damage through cytotoxic mechanisms. In this review, we focus on the recent advances in the study of the human adaptive immunological response in the pathogenesis of tegumentary leishmaniasis.Adaptive immunityHuman adaptive immunologyCutaneous leishmaniasisCD4 and CD8 T cellsLeishmania braziliensisImmune responseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8819/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALSantos CS The role....pdfSantos CS The role....pdfapplication/pdf462328https://www.arca.fiocruz.br/bitstream/icict/8819/2/Santos%20CS%20The%20role....pdf29982646040c3644342d714d2b17c314MD52TEXTSantos CS The role....pdf.txtSantos CS The role....pdf.txtExtracted texttext/plain43428https://www.arca.fiocruz.br/bitstream/icict/8819/3/Santos%20CS%20The%20role....pdf.txte5affafdebbcbeb44831326d979ff25dMD53icict/88192023-03-15 14:33:03.187oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
title The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
spellingShingle The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
Santos, Claire da Silva
Adaptive immunity
Human adaptive immunology
Cutaneous leishmaniasis
CD4 and CD8 T cells
Leishmania braziliensis
Immune response
title_short The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
title_full The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
title_fullStr The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
title_full_unstemmed The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
title_sort The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis.
author Santos, Claire da Silva
author_facet Santos, Claire da Silva
Brodskyn, Claudia Ida
author_role author
author2 Brodskyn, Claudia Ida
author2_role author
dc.contributor.author.fl_str_mv Santos, Claire da Silva
Brodskyn, Claudia Ida
dc.subject.en.pt_BR.fl_str_mv Adaptive immunity
Human adaptive immunology
Cutaneous leishmaniasis
CD4 and CD8 T cells
Leishmania braziliensis
Immune response
topic Adaptive immunity
Human adaptive immunology
Cutaneous leishmaniasis
CD4 and CD8 T cells
Leishmania braziliensis
Immune response
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-11-12T19:35:15Z
dc.date.available.fl_str_mv 2014-11-12T19:35:15Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, C. S.; BRODSKYN, C. I. The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. Frontiers Public Health, v. 2, p.165, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8819
dc.identifier.issn.none.fl_str_mv 2296-2565
dc.identifier.doi.none.fl_str_mv 10.3389/fpubh.2014.00165
identifier_str_mv SANTOS, C. S.; BRODSKYN, C. I. The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. Frontiers Public Health, v. 2, p.165, 2014.
2296-2565
10.3389/fpubh.2014.00165
url https://www.arca.fiocruz.br/handle/icict/8819
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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