Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

Detalhes bibliográficos
Autor(a) principal: Guimarães, Luiz Henrique Santos
Data de Publicação: 2016
Outros Autores: Queiroz, Adriano, Silva, Juliana Almeida da, Silva, Silvana Conceição da, Andrade, Viviane Magalhães, Lago, Ednaldo L, Machado, Paulo Roberto Lima, Bacellar, Maria Olívia Amado Ramos, Wilson, Mary E, Beverley, Stephen M, Carvalho Filho, Edgar Marcelino, Schriefer, Nicolaus Albert Borges
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18157
Resumo: U.S. National Institutes of Health (NIH), through grants NIH P50-AI30639-16 and NIH R03A167663-01. LHG was the recipient of a CAPES.
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spelling Guimarães, Luiz Henrique SantosQueiroz, AdrianoSilva, Juliana Almeida daSilva, Silvana Conceição daAndrade, Viviane MagalhãesLago, Ednaldo LMachado, Paulo Roberto LimaBacellar, Maria Olívia Amado RamosWilson, Mary EBeverley, Stephen MCarvalho Filho, Edgar MarcelinoSchriefer, Nicolaus Albert Borges2017-03-23T18:22:19Z2017-03-23T18:22:19Z2016GUIMARÃES, L. H. S. et al. Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects. PLoS Neglected Tropical Disease, v. 10, n. 12, p. e0005100, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/1815710.1371/journal.pntd.0005100U.S. National Institutes of Health (NIH), through grants NIH P50-AI30639-16 and NIH R03A167663-01. LHG was the recipient of a CAPES.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil / Universidade Federal do Sul da Bahia. Centro de Formação em Saúde. Teixeira de Freitas, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, BrasilUniversity of Iowa. Department of Internal Medicine. Iowa City, Iowa, USA / University of Iowa. Department of Microbiology. Iowa City, Iowa, USA / VA Medical Center. Iowa City, Iowa, USAUniversity School of Medicine. Department of Molecular Microbiology. Washington, Missouri, USAUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, BrasilAtypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. Methodology/Principal Findings Between 2005 and 2012, 51 ACL (cases) and 51 temporally matched cutaneous leishmaniasis (CL) subjects (controls) were enrolled and followed over time in Corte de Pedra. Clinical and therapeutic data were recorded for all subjects. Cytokine secretion by patients' peripheral blood mononuclear cells (PBMC) stimulated with soluble parasite antigen in vitro, and genotypes in a 600 base-pair locus in chromosome 28 (CHR28/425451) of the infecting L. (V.) braziliensis were compared between the two groups. ACL presented significantly more lesions in head and neck, and higher rate of antimony failure than CL. Cytosine±Adenine substitutions at CHR28/425451 positions 254 and 321 were highly associated with ACL (p<0.0001). In vitro stimulated ACL PBMCs produced lower levels of IFN-γ (p = 0.0002) and TNF (p <0.0001), and higher levels of IL-10 (p = 0.0006) and IL-17 (p = 0.0008) than CL PBMCs. Conclusions/Significance ACL found in Northeast Brazil is caused by distinct genotypes of L. (V.) braziliensis and presents a cytokine profile that departs from that in classical CL patients. We think that differences in antigenic contents among parasites may be in part responsible for the variation in cytokine responses and possibly immunopathology between CL and ACLengPublic Library of ScienceLeishmaniose CutâneaLeishmania BraziliensisImunologiaParasitologiaBrazilCutaneous LeishmaniasisLeishmania braziliensisImmunologyParasitologyBrazilAtypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18157/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGuimaraes LH Atypical manifestations....pdfGuimaraes LH Atypical 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dc.title.pt_BR.fl_str_mv Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
title Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
spellingShingle Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
Guimarães, Luiz Henrique Santos
Leishmaniose Cutânea
Leishmania Braziliensis
Imunologia
Parasitologia
Brazil
Cutaneous Leishmaniasis
Leishmania braziliensis
Immunology
Parasitology
Brazil
title_short Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
title_full Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
title_fullStr Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
title_full_unstemmed Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
title_sort Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
author Guimarães, Luiz Henrique Santos
author_facet Guimarães, Luiz Henrique Santos
Queiroz, Adriano
Silva, Juliana Almeida da
Silva, Silvana Conceição da
Andrade, Viviane Magalhães
Lago, Ednaldo L
Machado, Paulo Roberto Lima
Bacellar, Maria Olívia Amado Ramos
Wilson, Mary E
Beverley, Stephen M
Carvalho Filho, Edgar Marcelino
Schriefer, Nicolaus Albert Borges
author_role author
author2 Queiroz, Adriano
Silva, Juliana Almeida da
Silva, Silvana Conceição da
Andrade, Viviane Magalhães
Lago, Ednaldo L
Machado, Paulo Roberto Lima
Bacellar, Maria Olívia Amado Ramos
Wilson, Mary E
Beverley, Stephen M
Carvalho Filho, Edgar Marcelino
Schriefer, Nicolaus Albert Borges
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Luiz Henrique Santos
Queiroz, Adriano
Silva, Juliana Almeida da
Silva, Silvana Conceição da
Andrade, Viviane Magalhães
Lago, Ednaldo L
Machado, Paulo Roberto Lima
Bacellar, Maria Olívia Amado Ramos
Wilson, Mary E
Beverley, Stephen M
Carvalho Filho, Edgar Marcelino
Schriefer, Nicolaus Albert Borges
dc.subject.other.pt_BR.fl_str_mv Leishmaniose Cutânea
Leishmania Braziliensis
Imunologia
Parasitologia
Brazil
topic Leishmaniose Cutânea
Leishmania Braziliensis
Imunologia
Parasitologia
Brazil
Cutaneous Leishmaniasis
Leishmania braziliensis
Immunology
Parasitology
Brazil
dc.subject.en.pt_BR.fl_str_mv Cutaneous Leishmaniasis
Leishmania braziliensis
Immunology
Parasitology
Brazil
description U.S. National Institutes of Health (NIH), through grants NIH P50-AI30639-16 and NIH R03A167663-01. LHG was the recipient of a CAPES.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-23T18:22:19Z
dc.date.available.fl_str_mv 2017-03-23T18:22:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv GUIMARÃES, L. H. S. et al. Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects. PLoS Neglected Tropical Disease, v. 10, n. 12, p. e0005100, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18157
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005100
identifier_str_mv GUIMARÃES, L. H. S. et al. Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects. PLoS Neglected Tropical Disease, v. 10, n. 12, p. e0005100, 2016.
1935-2727
10.1371/journal.pntd.0005100
url https://www.arca.fiocruz.br/handle/icict/18157
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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