Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24938 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant CNPq 573839/2008-5). |
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Bagues, Naiara Carvalho TeixeiraPinheiro, Cristiane Garboggini Melo deBastos, Leila AndradeFraga, Deborah Bittencourt MothéVeras, Patrícia Sampaio TavaresPontes-de-Carvalho, Lain CarlosdosSantos, Washington Luis ConradoOliveira, Geraldo Gileno de Sá2018-02-26T13:58:56Z2018-02-26T13:58:56Z2018BAGUES, N. C. T. et al. Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis. Comparative Immunology, Microbiology and Infectious Diseases, v. 56, p. 14–19, 2018.0147-9571https://www.arca.fiocruz.br/handle/icict/2493810.1016/j.cimid.2017.11.003Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant CNPq 573839/2008-5).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. ,Escola de Medicina Veterinária. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilLeishmania infantum causes from subclinical infection to severe disease in humans and dogs. The spleen is one of the organs most affected by the infection. Although evidence exists that the parasitic load distribution and histological alterations may not be homogeneous in the affected organs of naturally infected individuals, it has not been formally demonstrated using the current techniques used for studying the disease. In six dogs naturally infected with Leishmania, parasitic load and histological changes were compared in samples collected from the lower, middle and upper third of the spleen. Parasitic load in the spleen of the group of dogs was variable, revealing a difference of 61 times between animals with the lowest and the highest parasitism. The set of parasitic load values of each dog showed a cluster trend, when compared to the other animals. Nevertheless, the parasitic load values of each dog showed a variation ranging from 3.2 to 34.7 times between lowest and highest value. Histological changes showed recognizable variation in frequency (granulomas) or intensity (perisplenitis) in the spleen of 2 out of the 6 dogs. The agreement of histological findings between samples collected from the different thirds of the spleen was good (kappa coeficient, 0.61-0.80) very good (0.81-0.99) or perfect (1.00), for most of the parameters analyzed. Variability of parasitic load and, to a lesser extent, histological changes in spleen of dogs with visceral leishmaniasis is observed. Such variability may be taken in account in the design of studies on pathogenesis, vaccine and therapeutic drug development.engElsevierLeishmaniose Visceral CaninaDistribuiçãoCachorroCarga parasitáriaBaçoCanine visceral leishmaniasisDistributionDogParasitic burdenSpleenParasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24938/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBagues NC Parasitic load and histological aspects....pdfBagues NC Parasitic load and histological aspects....pdfapplication/pdf688389https://www.arca.fiocruz.br/bitstream/icict/24938/2/Bagues%20NC%20Parasitic%20load%20and%20histological%20aspects....pdf1bb681c1e1dd7799e6f764a3a9bfeaafMD52TEXTBagues NC Parasitic load and histological aspects....pdf.txtBagues NC Parasitic load and histological aspects....pdf.txtExtracted texttext/plain34452https://www.arca.fiocruz.br/bitstream/icict/24938/3/Bagues%20NC%20Parasitic%20load%20and%20histological%20aspects....pdf.txt34ff6d6e1e162bc0a071861e990af046MD53icict/249382023-03-15 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| dc.title.pt_BR.fl_str_mv |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| title |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| spellingShingle |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis Bagues, Naiara Carvalho Teixeira Leishmaniose Visceral Canina Distribuição Cachorro Carga parasitária Baço Canine visceral leishmaniasis Distribution Dog Parasitic burden Spleen |
| title_short |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| title_full |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| title_fullStr |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| title_full_unstemmed |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| title_sort |
Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis |
| author |
Bagues, Naiara Carvalho Teixeira |
| author_facet |
Bagues, Naiara Carvalho Teixeira Pinheiro, Cristiane Garboggini Melo de Bastos, Leila Andrade Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado Oliveira, Geraldo Gileno de Sá |
| author_role |
author |
| author2 |
Pinheiro, Cristiane Garboggini Melo de Bastos, Leila Andrade Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado Oliveira, Geraldo Gileno de Sá |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bagues, Naiara Carvalho Teixeira Pinheiro, Cristiane Garboggini Melo de Bastos, Leila Andrade Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado Oliveira, Geraldo Gileno de Sá |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Visceral Canina Distribuição Cachorro Carga parasitária Baço |
| topic |
Leishmaniose Visceral Canina Distribuição Cachorro Carga parasitária Baço Canine visceral leishmaniasis Distribution Dog Parasitic burden Spleen |
| dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Distribution Dog Parasitic burden Spleen |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant CNPq 573839/2008-5). |
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2018 |
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2018-02-26T13:58:56Z |
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2018-02-26T13:58:56Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BAGUES, N. C. T. et al. Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis. Comparative Immunology, Microbiology and Infectious Diseases, v. 56, p. 14–19, 2018. |
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https://www.arca.fiocruz.br/handle/icict/24938 |
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0147-9571 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.cimid.2017.11.003 |
| identifier_str_mv |
BAGUES, N. C. T. et al. Parasitic load and histological aspects in different regions of the spleen of dogs with visceral leishmaniasis. Comparative Immunology, Microbiology and Infectious Diseases, v. 56, p. 14–19, 2018. 0147-9571 10.1016/j.cimid.2017.11.003 |
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Elsevier |
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Elsevier |
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