Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7316 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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Prates, Deboraci BritoSantos, Théo de AraújoLuz, Nívea FariasAndrade, Bruno de BezerrilCosta, Jaqueline FrançaAfonso, Lilian MariaClarêncio, JorgeMiranda, José CarlosBozza, Patrícia TorresReis, George A. dosBrodskyn, Claudia IdaBarral Netto, ManoelBorges, Valeria de MatosBarral, Aldina Maria Prado2014-02-17T19:36:00Z2014-02-17T19:36:00Z2011PRATES, D. B. et al. Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils. Journal of Leukocyte Biology, v. 90, n. 3, p.575-582, 2011.1938-3673https://www.arca.fiocruz.br/handle/icict/731610.1189/jlb.0211105engSociety for Leukocyte BiologyLutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophilsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Besthesda, MD, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilInstituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). Salvador, BA, BrasilNeutrophils are considered the host's first line of defense against infections and have been implicated in the immunopathogenesis of Leishmaniasis. Leishmania parasites are inoculated alongside vectors' saliva, which is a rich source of pharmacologically active substances that interfere with host immune response. In the present study, we tested the hypothesis that salivary components from Lutzomyia longipalpis, an important vector of visceral Leishmaniasis, enhance neutrophil apoptosis. Murine inflammatory peritoneal neutrophils cultured in the presence of SGS presented increased surface expression of FasL and underwent caspase-dependent and FasL-mediated apoptosis. This proapoptosis effect of SGS on neutrophils was abrogated by pretreatment with protease as well as preincubation with antisaliva antibodies. Furthermore, in the presence of Leishmania chagasi, SGS also increased apoptosis on neutrophils and increased PGE(2) release and decreased ROS production by neutrophils, while enhancing parasite viability inside these cells. The increased parasite burden was abrogated by treatment with z-VAD, a pan caspase inhibitor, and NS-398, a COX-2 inhibitor. In the presence of SGS, Leishmania-infected neutrophils produced higher levels of MCP-1 and attracted a high number of macrophages by chemotaxis in vitro assays. Both of these events were abrogated by pretreatment of neutrophils with bindarit, an inhibitor of CCL2/MCP-1 expression. Taken together, our data support the hypothesis that vector salivary proteins trigger caspase-dependent and FasL-mediated apoptosis, thereby favoring Leishmania survival inside neutrophils, which may represent an important mechanism for the establishment of Leishmania infection.ApoptoseLeishmaniose/imunologiaNeutrófilos/patologiaNeutrófilos/parasitologiaPsychodidae/imunologiaSaliva/imunologiaAnimaisCaspases/metabolismoQuimiotaxiaQuimiocina CCL2/metabolismoFemininoProteína Ligante Fas/metabolismoInterações Hospedeiro-ParasitaImmunoblottingLeishmaniaLeishmaniose/parasitologiaMacrófagos/imunologiaMasculinoCamundongosCamundongos Endogâmicos C57BLNeutrófilos/imunologiaPsychodidae/parasitologiaEspécies de Oxigênio Reativas/metabolismoSaliva/químicaSaliva/parasitologiaGlândulas Salivares/citologiaGlândulas Salivares/imunologiaGlândulas Salivares/parasitologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPrates, DB. et al. J. Leukoc Biol. 2011. v. 90, p. 575l.pdfPrates, DB. et al. J. Leukoc Biol. 2011. v. 90, p. 575l.pdfapplication/pdf1136176https://www.arca.fiocruz.br/bitstream/icict/7316/1/Prates%2c%20DB.%20et%20al.%20J.%20Leukoc%20Biol.%202011.%20v.%2090%2c%20p.%20575l.pdfaf97d4d5bb6968e2f71f1a300b84d15dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7316/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPrates, DB. et al. J. Leukoc Biol. 2011. v. 90, p. 575l.pdf.txtPrates, DB. et al. J. Leukoc Biol. 2011. v. 90, p. 575l.pdf.txtExtracted texttext/plain47921https://www.arca.fiocruz.br/bitstream/icict/7316/5/Prates%2c%20DB.%20et%20al.%20J.%20Leukoc%20Biol.%202011.%20v.%2090%2c%20p.%20575l.pdf.txtd607eeeb2d7f6b753bdc7a97a2923b8fMD55THUMBNAILPrates, DB. et al. J. Leukoc Biol. 2011. v. 90, p. 575l.pdf.jpgPrates, DB. et al. J. 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dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
title |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
spellingShingle |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils Prates, Deboraci Brito Apoptose Leishmaniose/imunologia Neutrófilos/patologia Neutrófilos/parasitologia Psychodidae/imunologia Saliva/imunologia Animais Caspases/metabolismo Quimiotaxia Quimiocina CCL2/metabolismo Feminino Proteína Ligante Fas/metabolismo Interações Hospedeiro-Parasita Immunoblotting Leishmania Leishmaniose/parasitologia Macrófagos/imunologia Masculino Camundongos Camundongos Endogâmicos C57BL Neutrófilos/imunologia Psychodidae/parasitologia Espécies de Oxigênio Reativas/metabolismo Saliva/química Saliva/parasitologia Glândulas Salivares/citologia Glândulas Salivares/imunologia Glândulas Salivares/parasitologia |
title_short |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
title_full |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
title_fullStr |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
title_full_unstemmed |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
title_sort |
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils |
author |
Prates, Deboraci Brito |
author_facet |
Prates, Deboraci Brito Santos, Théo de Araújo Luz, Nívea Farias Andrade, Bruno de Bezerril Costa, Jaqueline França Afonso, Lilian Maria Clarêncio, Jorge Miranda, José Carlos Bozza, Patrícia Torres Reis, George A. dos Brodskyn, Claudia Ida Barral Netto, Manoel Borges, Valeria de Matos Barral, Aldina Maria Prado |
author_role |
author |
author2 |
Santos, Théo de Araújo Luz, Nívea Farias Andrade, Bruno de Bezerril Costa, Jaqueline França Afonso, Lilian Maria Clarêncio, Jorge Miranda, José Carlos Bozza, Patrícia Torres Reis, George A. dos Brodskyn, Claudia Ida Barral Netto, Manoel Borges, Valeria de Matos Barral, Aldina Maria Prado |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Prates, Deboraci Brito Santos, Théo de Araújo Luz, Nívea Farias Andrade, Bruno de Bezerril Costa, Jaqueline França Afonso, Lilian Maria Clarêncio, Jorge Miranda, José Carlos Bozza, Patrícia Torres Reis, George A. dos Brodskyn, Claudia Ida Barral Netto, Manoel Borges, Valeria de Matos Barral, Aldina Maria Prado |
dc.subject.decs.pt_BR.fl_str_mv |
Apoptose Leishmaniose/imunologia Neutrófilos/patologia Neutrófilos/parasitologia Psychodidae/imunologia Saliva/imunologia Animais Caspases/metabolismo Quimiotaxia Quimiocina CCL2/metabolismo Feminino Proteína Ligante Fas/metabolismo Interações Hospedeiro-Parasita Immunoblotting Leishmania Leishmaniose/parasitologia Macrófagos/imunologia Masculino Camundongos Camundongos Endogâmicos C57BL Neutrófilos/imunologia Psychodidae/parasitologia Espécies de Oxigênio Reativas/metabolismo Saliva/química Saliva/parasitologia Glândulas Salivares/citologia Glândulas Salivares/imunologia Glândulas Salivares/parasitologia |
topic |
Apoptose Leishmaniose/imunologia Neutrófilos/patologia Neutrófilos/parasitologia Psychodidae/imunologia Saliva/imunologia Animais Caspases/metabolismo Quimiotaxia Quimiocina CCL2/metabolismo Feminino Proteína Ligante Fas/metabolismo Interações Hospedeiro-Parasita Immunoblotting Leishmania Leishmaniose/parasitologia Macrófagos/imunologia Masculino Camundongos Camundongos Endogâmicos C57BL Neutrófilos/imunologia Psychodidae/parasitologia Espécies de Oxigênio Reativas/metabolismo Saliva/química Saliva/parasitologia Glândulas Salivares/citologia Glândulas Salivares/imunologia Glândulas Salivares/parasitologia |
description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-02-17T19:36:00Z |
dc.date.available.fl_str_mv |
2014-02-17T19:36:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
PRATES, D. B. et al. Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils. Journal of Leukocyte Biology, v. 90, n. 3, p.575-582, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7316 |
dc.identifier.issn.none.fl_str_mv |
1938-3673 |
dc.identifier.doi.none.fl_str_mv |
10.1189/jlb.0211105 |
identifier_str_mv |
PRATES, D. B. et al. Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils. Journal of Leukocyte Biology, v. 90, n. 3, p.575-582, 2011. 1938-3673 10.1189/jlb.0211105 |
url |
https://www.arca.fiocruz.br/handle/icict/7316 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Society for Leukocyte Biology |
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Society for Leukocyte Biology |
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