Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection

Detalhes bibliográficos
Autor(a) principal: Daniel-Ribeiro, Claudio Tadeu
Data de Publicação: 1992
Outros Autores: Ferreira, J. Oliveira, Cruz, M. F. Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43549
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Daniel-Ribeiro, Claudio TadeuFerreira, J. OliveiraCruz, M. F. Ferreira da2020-09-22T18:21:43Z2020-09-22T18:21:43Z1992DANIEL-RIBEIRO, Claudio Tadeu; FERREIRA, J. Oliveira; CRUZ, M. F. Ferreira da. Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 5, p. 117-124, 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/4354910.1590/S0074-027619920009000181678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.MaláriaAbordagens imunológicasTransmissãoImunidadeDiagnósticoInfecção plasmodialMalariaImmunological approachesTransmissionImunityDiagnosePlasmodial infectionModern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.The present paper reviews our recent data concerning the use of immunological methods employing monoclonal antibodies and synthetic peptides to study malaria transmission and immunity and to diagnose plasmodial infection. As concerns malaria transmission, we studied the main vectors of human malaria and the plasmodial species transmitted in endemic areas of Rondônia state, Brazil. The natural infection on anopheline was evaluated by immunoradiometric assay (IRMA) using monoclonal antibodies to an immunodominant sporozoite surface antigen (CS protein) demonstrated to be species specific. Our results showed that among six species of Anopheles found infected, An. darlingi was the main vector transmitting Plasmodium falciparum and P. vivax malaria in the immediate vicinity of houses. In order to assess the level of anti-CS antibodies we studied, by IRMA using the synthetic peptide corresponding to the repetitive epitope of the sporozoite CS protein, sera of individuals living in the same areas where the entomological survey has been performed. In this assay the prevalence of anti-CS antibodies was very low and did not reflect the malaria transmission rate in the studied areas. In relation to malaria diagnosis, a monoclonal antibody specific to an epitope of a 50 kDa exoantigen, the major component of supernatant collected at the time of schizont rupture, was used as a probe for the detection of P. falciparum antigens. This assay seemed to be more sensitive than parasitological examination for malaria diagnosis since it was able to detect plasmodial antigens in both symptomatic and asymtomatic individuals with negative thick blood smear at different intervals after a last parasitologically confirmed confirmed attack of malaria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43549/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCTDanielRibeiro_MFFCruz_etal_IOC_1992.pdfCTDanielRibeiro_MFFCruz_etal_IOC_1992.pdfapplication/pdf510712https://www.arca.fiocruz.br/bitstream/icict/43549/2/CTDanielRibeiro_MFFCruz_etal_IOC_1992.pdfcf2467b4d82a9188fc8c837197a0126cMD52TEXTCTDanielRibeiro_MFFCruz_etal_IOC_1992.pdf.txtCTDanielRibeiro_MFFCruz_etal_IOC_1992.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
title Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
spellingShingle Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
Daniel-Ribeiro, Claudio Tadeu
Malária
Abordagens imunológicas
Transmissão
Imunidade
Diagnóstico
Infecção plasmodial
Malaria
Immunological approaches
Transmission
Imunity
Diagnose
Plasmodial infection
title_short Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
title_full Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
title_fullStr Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
title_full_unstemmed Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
title_sort Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection
author Daniel-Ribeiro, Claudio Tadeu
author_facet Daniel-Ribeiro, Claudio Tadeu
Ferreira, J. Oliveira
Cruz, M. F. Ferreira da
author_role author
author2 Ferreira, J. Oliveira
Cruz, M. F. Ferreira da
author2_role author
author
dc.contributor.author.fl_str_mv Daniel-Ribeiro, Claudio Tadeu
Ferreira, J. Oliveira
Cruz, M. F. Ferreira da
dc.subject.other.pt_BR.fl_str_mv Malária
Abordagens imunológicas
Transmissão
Imunidade
Diagnóstico
Infecção plasmodial
topic Malária
Abordagens imunológicas
Transmissão
Imunidade
Diagnóstico
Infecção plasmodial
Malaria
Immunological approaches
Transmission
Imunity
Diagnose
Plasmodial infection
dc.subject.en.pt_BR.fl_str_mv Malaria
Immunological approaches
Transmission
Imunity
Diagnose
Plasmodial infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2020-09-22T18:21:43Z
dc.date.available.fl_str_mv 2020-09-22T18:21:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DANIEL-RIBEIRO, Claudio Tadeu; FERREIRA, J. Oliveira; CRUZ, M. F. Ferreira da. Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 5, p. 117-124, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43549
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761992000900018
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv DANIEL-RIBEIRO, Claudio Tadeu; FERREIRA, J. Oliveira; CRUZ, M. F. Ferreira da. Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 5, p. 117-124, 1992.
0074-0276
10.1590/S0074-02761992000900018
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43549
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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